NP_001124437.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,932 Da
NCBI Official Full Name
SUN domain-containing protein 1 isoform a
NCBI Official Synonym Full Names
Sad1 and UNC84 domain containing 1
NCBI Official Synonym Symbols
NCBI Protein Information
SUN domain-containing protein 1
UniProt Protein Name
SUN domain-containing protein 1
UniProt Synonym Protein Names
Protein unc-84 homolog A; Sad1/unc-84 protein-like 1
UniProt Synonym Gene Names
NCBI Summary for SUN1
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]
UniProt Comments for SUN1
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis.
Research Articles on SUN1
Precautions
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Pathways associated with SUN1 recombinant protein
Diseases associated with SUN1 recombinant protein
Organs/Tissues associated with SUN1 recombinant protein
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