NP_001003214.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
NCBI Official Synonym Symbols
NCBI Protein Information
sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic reticulum Ca2+-transport ATPase isoform; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
UniProt Protein Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt Synonym Protein Names
Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
UniProt Synonym Gene Names
UniProt Entry Name
AT2A2_CANFA
UniProt Comments for ATP2A2
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle
By similarity.
Catalytic activity: ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).
Enzyme regulation: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.
Subunit structure: Associated with phospholamban (PLN). Isoform SERCA2B interacts with TRAM2 (via C-terminus). Interacts with HAX1
By similarity. Interacts with S100A8 and S100A9
By similarity.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed.
Post-translational modification: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity
By similarity.
Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]
Research Articles on ATP2A2
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Pathways associated with ATP2A2 recombinant protein
Diseases associated with ATP2A2 recombinant protein
Organs/Tissues associated with ATP2A2 recombinant protein
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