NP_444324.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32.2 kDa
NCBI Official Full Name
scavenger receptor cysteine-rich type 1 protein M130 isoform 2
NCBI Official Synonym Full Names
CD163 antigen
NCBI Protein Information
scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
UniProt Synonym Protein Names
CD_antigen: CD163
UniProt Synonym Gene Names
UniProt Entry Name
C163A_MOUSE
UniProt Comments for Cd163
CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: extracellular region; integral to membrane; membrane; plasma membrane
Molecular Function: scavenger receptor activity
Biological Process: acute-phase response; inflammatory response
Product References and Citations for Cd163 recombinant protein
Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteine-rich family.Schaer D.J., Boretti F.S., Hongegger A., Poehler D., Linnscheid P., Staege H., Mueller C., Schoedon G., Schaffner A.Immunogenetics 53:170-177(2001)
Scavenger receptor cd163 is a cell permissive factor for infection with porcine reproductive and respiratory syndrome viruses.Welch S.-K.W., Calvert J.G., Slade D.E., Shields S.L. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Research Articles on Cd163
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Products associated with Cd163 recombinant protein
Pathways associated with Cd163 recombinant protein
Diseases associated with Cd163 recombinant protein
Organs/Tissues associated with Cd163 recombinant protein
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