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PLA2G2A recombinant protein :: Secreted Phospholipase A2-IIA Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142431 PLA2G2A recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,170 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Secreted Phospholipase A2-IIA (PLA2G2A), Recombinant Protein

 Also Known As   

Recombinant Human Secreted Phospholipase A2-IIA

 Product Synonym Names    PLA2G2A Human; Secreted Phospholipase A2-IIA Human Recombinant; MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2; Phospholipase A2 membrane associated; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase; Group IIA phospholipase A2; GIIC sPLA2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; sPLA2-IIA; PLA2G2A
 Product Gene Name   

PLA2G2A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    172411
 3D Structure    ModBase 3D Structure for P14555
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    Lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
Sterile Filtered lyophilized (freeze-dried) powder.
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 Solubility    Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of PLA2G2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PLA2G2A recombinant protein

   Description: Secreted Phospholipase A2-IIA Human Recombinant is manufactured with N-terminal fusion of HisTag. PLA2G2A His-Tagged Fusion Protein is 15.8 kDa containing 124 amino acid residues of the human secreted phospholipase A2-IIA and 16 additional amino acid residues HisTag.

Introduction: Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators.The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of lowmolecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense.This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso- PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci.In mice, sPLA2 expression significantly influences HDL particle size and composition and demonstrate that an induction of sPLA2 is required for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.sPLA2-IIA can exert beneficial action in the context of infectious diseases since recent studies have shown that this enzyme exhibits potent bactericidal effects. Induction of the synthesis of sPLA2-IIA is generally initiated by endotoxin and a limited number of cytokines via paracrine and/or autocrine processes.
 Product Categories/Family for PLA2G2A recombinant protein    ENZYMES; Enzymes; Secreted Phospholipase A2
NCBI/Uniprot data below describe general gene information for PLA2G2A. It may not necessarily be applicable to this product.
 NCBI GI #    4505849
 NCBI GeneID    5320
 NCBI Accession #    NP_000291.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000300.3 [Other Products]
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 UniProt Primary Accession #    P14555 [Other Products]
 UniProt Secondary Accession #    Q6DN24; Q6IBD9; Q9UCD2; A8K5I7 [Other Products]
 UniProt Related Accession #    P14555 [Other Products]
 Molecular Weight    16,083 Da
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 NCBI Official Full Name    phospholipase A2, membrane associated
 NCBI Official Synonym Full Names    phospholipase A2, group IIA (platelets, synovial fluid)
 NCBI Official Symbol    PLA2G2A [Similar Products]
 NCBI Official Synonym Symbols   
MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
[Similar Products]
 NCBI Protein Information    phospholipase A2, membrane associated; GIIC sPLA2; NPS-PLA2; group IIA phospholipase A2; non-pancreatic secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A
 UniProt Protein Name    Phospholipase A2, membrane associated
 UniProt Synonym Protein Names   
GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A
 Protein Family    Phospholipase
 UniProt Gene Name    PLA2G2A [Similar Products]
 UniProt Synonym Gene Names    PLA2B; PLA2L; RASF-A; NPS-PLA2 [Similar Products]
 UniProt Entry Name    PA2GA_HUMAN
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 NCBI Summary for PLA2G2A    The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for PLA2G2A    PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.

Protein type: Lipid Metabolism - arachidonic acid; Mitochondrial; Lipid Metabolism - ether lipid; Secreted, signal peptide; Phospholipase; Vesicle; Secreted; Lipid Metabolism - alpha-linolenic acid; EC 3.1.1.4; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: extracellular space; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; extracellular region; secretory granule

Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; phospholipid binding; calcium ion binding

Biological Process: defense response to Gram-positive bacterium; somatic stem cell maintenance; phosphatidic acid metabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process; negative regulation of epithelial cell proliferation; positive regulation of inflammatory response

Disease: Colorectal Cancer
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 Research Articles on PLA2G2A    1. Findings support the notion that sPLA2-IIa functions as a ligand for the EGFR family of receptors leading to an elevated HER/HER2-elicited signaling lung cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLA2G2A recombinant proteinPathways associated with PLA2G2A recombinant protein
 Reference Product  PubMed Publications
 PTGS2 recombinant protein  >7 publications with PLA2G2A and PTGS2
 PLA2G7 recombinant protein  >2 publications with PLA2G2A and PLA2G7
 PTGS1 recombinant protein  >2 publications with PLA2G2A and PTGS1
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
Diseases associated with PLA2G2A recombinant proteinOrgans/Tissues associated with PLA2G2A recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with PLA2G2A and Inflammation
 Colorectal Neoplasms Antibodies  >25 publications with PLA2G2A and Colorectal Neoplasms
 Heart Diseases Antibodies  >8 publications with PLA2G2A and Heart Diseases
 Atherosclerosis Antibodies  >8 publications with PLA2G2A and Atherosclerosis
 Lung Neoplasms Antibodies  >7 publications with PLA2G2A and Lung Neoplasms
 Necrosis Antibodies  >5 publications with PLA2G2A and Necrosis
 Myocardial Ischemia Antibodies  >5 publications with PLA2G2A and Myocardial Ischemia
 Liver Diseases Antibodies  >4 publications with PLA2G2A and Liver Diseases
 Hyperplasia Antibodies  >4 publications with PLA2G2A and Hyperplasia
 Colitis Antibodies  >4 publications with PLA2G2A and Colitis
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >38 publications with PLA2G2A and Intestine
 Heart Antibodies  >11 publications with PLA2G2A and Heart
 Lung Antibodies  >11 publications with PLA2G2A and Lung
 Stomach Antibodies  >9 publications with PLA2G2A and Stomach
 Liver Antibodies  >7 publications with PLA2G2A and Liver
 Vascular Antibodies  >7 publications with PLA2G2A and Vascular
 Prostate Antibodies  >5 publications with PLA2G2A and Prostate
 Brain Antibodies  >3 publications with PLA2G2A and Brain
 Uterus Antibodies  >3 publications with PLA2G2A and Uterus
 Muscle Antibodies  >2 publications with PLA2G2A and Muscle
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