NP_000291.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
phospholipase A2, membrane associated
NCBI Official Synonym Full Names
phospholipase A2, group IIA (platelets, synovial fluid)
NCBI Official Synonym Symbols
MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2 [Similar Products]
NCBI Protein Information
phospholipase A2, membrane associated; GIIC sPLA2; NPS-PLA2; group IIA phospholipase A2; non-pancreatic secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A
UniProt Protein Name
Phospholipase A2, membrane associated
UniProt Synonym Protein Names
GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A
UniProt Synonym Gene Names
UniProt Entry Name
PA2GA_HUMAN
NCBI Summary for PLA2G2A
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for PLA2G2A
PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.
Protein type: Lipid Metabolism - arachidonic acid; Mitochondrial; Lipid Metabolism - ether lipid; Secreted, signal peptide; Phospholipase; Vesicle; Secreted; Lipid Metabolism - alpha-linolenic acid; EC 3.1.1.4; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p35
Cellular Component: extracellular space; endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; extracellular region; secretory granule
Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; phospholipid binding; calcium ion binding
Biological Process: defense response to Gram-positive bacterium; somatic stem cell maintenance; phosphatidic acid metabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process; negative regulation of epithelial cell proliferation; positive regulation of inflammatory response
Disease: Colorectal Cancer
Research Articles on PLA2G2A
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Products associated with PLA2G2A recombinant protein
Pathways associated with PLA2G2A recombinant protein
Diseases associated with PLA2G2A recombinant protein
Organs/Tissues associated with PLA2G2A recombinant protein
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