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PLA2G12 recombinant protein :: Secreted Phospholipase A2-XII Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142471 PLA2G12 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,170 +5 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Secreted Phospholipase A2-XII (PLA2G12), Recombinant Protein

 Also Known As   

Recombinant Human Secreted Phospholipase A2-XII

 Product Synonym Names    PLA2G12 Human; Secreted Phospholipase A2-XII Human Recombinant; Group XIIA secretory phospholipase A2; EC; Phosphatidylcholine 2-acylhydrolase GXII; GXII sPLA2; PLA2G12; sPLA2-XII; PLA2G12A
 Product Gene Name   

PLA2G12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611652
 3D Structure    ModBase 3D Structure for Q9BZM1
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.01M Tris buffer pH 8.6.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of PLA2G12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PLA2G12 recombinant protein

   Introduction: Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators.The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of low molecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense.This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso- PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci.In mice, sPLA2 expression significantly influences HDL particle size and composition and demonstrate that an induction of sPLA2 is required for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.
 Product Categories/Family for PLA2G12 recombinant protein    ENZYMES; Enzymes; Secreted Phospholipase A2
 Applications Tested/Suitable for PLA2G12 recombinant protein   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PLA2G12. It may not necessarily be applicable to this product.
 NCBI GI #    21361944
 NCBI GeneID    81579
 NCBI Accession #    NP_110448.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030821.4 [Other Products]
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 UniProt Primary Accession #    Q9BZM1 [Other Products]
 UniProt Secondary Accession #    Q9BZ89 [Other Products]
 UniProt Related Accession #    Q9BZM1 [Other Products]
 Molecular Weight    21,067 Da
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 NCBI Official Full Name    group XIIA secretory phospholipase A2
 NCBI Official Synonym Full Names    phospholipase A2, group XIIA
 NCBI Official Symbol    PLA2G12A [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    group XIIA secretory phospholipase A2; GXII sPLA2; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2, group XII; sPLA2-XII
 UniProt Protein Name    Group XIIA secretory phospholipase A2
 UniProt Synonym Protein Names   
Phosphatidylcholine 2-acylhydrolase 12A
 UniProt Gene Name    PLA2G12A [Similar Products]
 UniProt Synonym Gene Names    PLA2G12; GXII sPLA2; sPLA2-XII [Similar Products]
 UniProt Entry Name    PG12A_HUMAN
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 NCBI Summary for PLA2G12    Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for PLA2G12    PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family.

Protein type: Phospholipase; Lipid Metabolism - linoleic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Secreted, signal peptide; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; EC; Secreted; Lipid Metabolism - alpha-linolenic acid

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: Golgi apparatus; endoplasmic reticulum; extracellular region

Molecular Function: calcium-dependent phospholipase A2 activity; calcium ion binding

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process
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 Research Articles on PLA2G12    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLA2G12 recombinant proteinPathways associated with PLA2G12 recombinant protein
 Reference Product  PubMed Publications
 PTGS2 recombinant protein  >1 publications with PLA2G12 and PTGS2
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
Diseases associated with PLA2G12 recombinant proteinOrgans/Tissues associated with PLA2G12 recombinant protein
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >1 publications with PLA2G12 and Fatty Liver
 Inflammation Antibodies  >1 publications with PLA2G12 and Inflammation
 Hypertrophy Antibodies  >1 publications with PLA2G12 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with PLA2G12 and Hyperplasia
 Necrosis Antibodies  >1 publications with PLA2G12 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with PLA2G12 and Liver
 Blood Antibodies  >2 publications with PLA2G12 and Blood
 Spleen Antibodies  >1 publications with PLA2G12 and Spleen
 Eye Antibodies  >1 publications with PLA2G12 and Eye
 Intestine Antibodies  >1 publications with PLA2G12 and Intestine
 Heart Antibodies  >1 publications with PLA2G12 and Heart
 Muscle Antibodies  >1 publications with PLA2G12 and Muscle
 Vascular Antibodies  >1 publications with PLA2G12 and Vascular
 Lung Antibodies  >1 publications with PLA2G12 and Lung
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