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SLPI recombinant protein :: Secretory Leukocyte Peptidase Inhibitor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144051 SLPI recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Secretory Leukocyte Peptidase Inhibitor (SLPI), Recombinant Protein

 Also Known As   

Recombinant Human Secretory Leukocyte Peptidase Inhibitor

 Product Synonym Names    SLPI Human; Secretory Leukocyte Peptidase Inhibitor Human Recombinant; Antileukoproteinase; ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4; WAP four-disulfide core domain protein 4; Protease inhibitor WAP4; Seminal proteinase inhibitor; Mucus proteinase inhibitor
 Product Gene Name   

SLPI recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    26-132
 Sequence    MGSSHHHHHH SSGLVPRGSH MSGKSFKAGV CPPKKSAQCL RYKKPECQSD WQCPGKKRCC PDTCGIKCLD PVDTPNPTRR KPGKCPVTYG QCLMLNPPNF CEMDGQCKRD LKCCMGMCGK SCVSPVKA.
 OMIM    107285
 3D Structure    ModBase 3D Structure for P03973
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 Purity/Purification    Greater than 80.0% as determined by SDS-PAGE.
 Form/Format    SLPI Human solution containing 20mM Tris-HCl pH-8.0, 2mM DTT, 0.1M NaCl & 20% glycerol.
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 Source    Escherichia Coli.
 Physical Appearance    Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SLPI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SLPI recombinant protein

   Description: SLPI Recombinant E Coli produced in E Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (26-132 a.a.) and having a molecular mass of 14 kDa. The SLPI is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: SLPI is a secreted inhibitor which guards epithelial tissues from serine proteases. SLPI is localized in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. SLPI inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. SLPI protein has broad-spectrum anti-biotic activity. SLPI is an acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. SLPI prevents elastase-mediated damage to oral and mucosal tissues.
 Product Categories/Family for SLPI recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for SLPI. It may not necessarily be applicable to this product.
 NCBI GI #    4507065
 NCBI GeneID    6590
 NCBI Accession #    NP_003055.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003064.3 [Other Products]
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 UniProt Primary Accession #    P03973 [Other Products]
 UniProt Secondary Accession #    P07757; B2R5H8 [Other Products]
 UniProt Related Accession #    P03973 [Other Products]
 Molecular Weight    14,326 Da
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 NCBI Official Full Name    antileukoproteinase
 NCBI Official Synonym Full Names    secretory leukocyte peptidase inhibitor
 NCBI Official Symbol    SLPI [Similar Products]
 NCBI Official Synonym Symbols   
ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
[Similar Products]
 NCBI Protein Information    antileukoproteinase; HUSI-1; WAP four-disulfide core domain protein 4; mucus proteinase inhibitor; protease inhibitor WAP4; secretory leukocyte protease inhibitor (antileukoproteinase); seminal proteinase inhibitor
 UniProt Protein Name    Antileukoproteinase
 UniProt Synonym Protein Names   
BLPI; HUSI-1; Mucus proteinase inhibitor; MPI; Protease inhibitor WAP4; Secretory leukocyte protease inhibitor; Seminal proteinase inhibitor; WAP four-disulfide core domain protein 4
 Protein Family    Antileukoproteinase
 UniProt Gene Name    SLPI [Similar Products]
 UniProt Synonym Gene Names    WAP4; WFDC4; ALP; MPI [Similar Products]
 UniProt Entry Name    SLPI_HUMAN
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 NCBI Summary for SLPI    This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
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 UniProt Comments for SLPI    SLPI: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: extracellular matrix

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; endopeptidase inhibitor activity

Biological Process: negative regulation of viral genome replication; negative regulation of protein binding
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 Research Articles on SLPI    1. Both mRNA and protein levels of SLPI were significantly higher in patients with biofilm associated chronic rhinosinusitis (CRS) than those with CRS and no biofilm and controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SLPI recombinant proteinDiseases associated with SLPI recombinant protein
 Reference Product  PubMed Publications
 CD4 recombinant protein  >23 publications with SLPI and CD4
 TGFB1 recombinant protein  >12 publications with SLPI and TGFB1
 GRN recombinant protein  >8 publications with SLPI and GRN
 LCN2 recombinant protein  >7 publications with SLPI and LCN2
 IL6 recombinant protein  >7 publications with SLPI and IL6
 CCND1 recombinant protein  >6 publications with SLPI and CCND1
 EGF recombinant protein  >6 publications with SLPI and EGF
 ANXA2 recombinant protein  >5 publications with SLPI and ANXA2
 IRF1 recombinant protein  >1 publications with SLPI and IRF1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >179 publications with SLPI and Inflammation
 Lung Diseases Antibodies  >142 publications with SLPI and Lung Diseases
 Necrosis Antibodies  >59 publications with SLPI and Necrosis
 Fibrosis Antibodies  >35 publications with SLPI and Fibrosis
 Disease Models, Animal Antibodies  >29 publications with SLPI and Disease Models, Animal
 Lung Injury Antibodies  >29 publications with SLPI and Lung Injury
 Pneumonia Antibodies  >21 publications with SLPI and Pneumonia
 Cardiovascular Diseases Antibodies  >21 publications with SLPI and Cardiovascular Diseases
 Vascular Diseases Antibodies  >18 publications with SLPI and Vascular Diseases
 Lung Neoplasms Antibodies  >18 publications with SLPI and Lung Neoplasms
Organs/Tissues associated with SLPI recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >187 publications with SLPI and Lung
 Blood Antibodies  >171 publications with SLPI and Blood
 Uterus Antibodies  >38 publications with SLPI and Uterus
 Skin Antibodies  >32 publications with SLPI and Skin
 Mouth Antibodies  >31 publications with SLPI and Mouth
 Cervix Antibodies  >26 publications with SLPI and Cervix
 Heart Antibodies  >25 publications with SLPI and Heart
 Liver Antibodies  >19 publications with SLPI and Liver
 Intestine Antibodies  >19 publications with SLPI and Intestine
 Trachea Antibodies  >15 publications with SLPI and Trachea
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