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Pttg1 recombinant protein :: Securin (Pttg1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717749 Pttg1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $595 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $745 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $800 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $880 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $895 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,130 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,240 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,635 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Securin (Pttg1), Recombinant Protein

 Also Known As   

Recombinant Rat Securin (Pttg1)

 Product Synonym Names    Securin; Pituitary tumor-transforming gene 1 protein
 Product Gene Name   

Pttg1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Pttg1; Pttg [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-199aa; Full length protein
 Sequence    ATLIFVDKD NEEPGSRLAS KDGLKLGSGV KALDGKLQVS TPRVGKVFGA PGLPKASRKA LGTVNRVTEK PVKSSKPLQS KQPTLSVKKI TEKSTKTQGS APAPDDAYPE IEKFFPFDPL DFESFDLPEE HQISLLPLNG VPLMILNEER GLEKLLHLDP PSPLQKPFLP WESDPLPSPP SALSALDVEL PPVCYDADI
 3D Structure    ModBase 3D Structure for P97613
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pttg1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Pttg1 recombinant protein

   The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
NCBI/Uniprot data below describe general gene information for Pttg1. It may not necessarily be applicable to this product.
 NCBI GI #    11761541
 NCBI GeneID    64193
 NCBI Accession #    NP_071786.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022391.2 [Other Products]
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 UniProt Primary Accession #    P97613 [Other Products]
 UniProt Related Accession #    P97613 [Other Products]
 Molecular Weight    21,571 Da
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 NCBI Official Full Name    securin
 NCBI Official Synonym Full Names    pituitary tumor-transforming 1
 NCBI Official Symbol    Pttg1 [Similar Products]
 NCBI Official Synonym Symbols   
Pttg
[Similar Products]
 NCBI Protein Information    securin; Pituitary tumor transforming; pituitary tumor-transforming gene 1 protein
 UniProt Protein Name    Securin
 UniProt Synonym Protein Names   
Pituitary tumor-transforming gene 1 protein
 UniProt Gene Name    Pttg1 [Similar Products]
 UniProt Synonym Gene Names    Pttg [Similar Products]
 UniProt Entry Name    PTTG1_RAT
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 UniProt Comments for Pttg1    Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family.

Protein type: Oncoprotein; Cell cycle regulation

Cellular Component: cytoplasm; nucleus

Molecular Function: heat shock protein binding; ribosome binding; cysteine protease inhibitor activity; SH3 domain binding

Biological Process: mitosis; negative regulation of cell proliferation; homologous chromosome segregation; cell division; regulation of cell growth; DNA repair; chromosome organization and biogenesis; chromosome segregation
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 Research Articles on Pttg1    1. pttg1 could predict inter-individual susceptibility to D-galactosamine induced hepatotoxicity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Pttg1 recombinant proteinDiseases associated with Pttg1 recombinant protein
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >93 publications with Pttg1 and Nervous System Diseases
 Carcinoma Antibodies  >86 publications with Pttg1 and Carcinoma
 Chromosome Aberrations Antibodies  >56 publications with Pttg1 and Chromosome Aberrations
 Adenoma Antibodies  >49 publications with Pttg1 and Adenoma
 Cell Transformation, Neoplastic Antibodies  >48 publications with Pttg1 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >46 publications with Pttg1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >41 publications with Pttg1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >33 publications with Pttg1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >24 publications with Pttg1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >24 publications with Pttg1 and Neoplasms, Experimental
Organs/Tissues associated with Pttg1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Pituitary Gland Antibodies  >38 publications with Pttg1 and Pituitary Gland
 Lung Antibodies  >34 publications with Pttg1 and Lung
 Testis Antibodies  >23 publications with Pttg1 and Testis
 Kidney Antibodies  >19 publications with Pttg1 and Kidney
 Colon Antibodies  >18 publications with Pttg1 and Colon
 Prostate Antibodies  >18 publications with Pttg1 and Prostate
 Heart Antibodies  >7 publications with Pttg1 and Heart
 Placenta Antibodies  >5 publications with Pttg1 and Placenta
 Embryonic Tissue Antibodies  >5 publications with Pttg1 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >2 publications with Pttg1 and Uncharacterized Tissue
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