Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow SELPLG  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Retinoblastoma (RB1) Antibody
 • Resistin ELISA Kit
 • Dopa Decarboxylase (DDC) Recombinant Protein
 • Melanoma-Associated Antigen B16 (MAGEB16) ELISA Kit
 • Osteocalcin (Bglap) ELISA Kit
 • Chimeric Chagas Recombinant Protein
 • ZCCHC17 Recombinant Protein
 • SLC37A2 Antibody
 • ELAVL4 Antibody
 • Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) ELISA Kit
 • Growth-differentiation factor 15 (GDF15) Antibody
 • CDH11 Antibody
 • Melanoma Inhibitory Activity (MIA) Recombinant Protein
 • Basigin - Emmprin - CD147 (BSG) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SELPLG recombinant protein :: Selectin P Ligand Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS146316 SELPLG recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Selectin P Ligand (SELPLG), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Selectin P Ligand

 Product Synonym Names    Cutaneous Lymphocyte-Associated Associated Antigen, Selectin P Ligand, PSGL-1, CD162 Antigen, P-Selectin Glycoprotein Ligand 1, CLA
 Product Gene Name   

SELPLG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHH HHH SSGLVPRGSH MGSQAT EYEY LDYDFLPETE PPEMLRNSTD TTPLTGPGTP ESTTVEPAAR RSTGLDAGGA VTELTTELAN MGNLSTDSAA MEI
 OMIM    600738
Section Bar
Section Bar
 Purity/Purification    Greater than 80% as determined by SDS-PAGE.
 Form/Format    The SELPLG solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
 Concentration    0.25mg/ml (lot specific)
Section Bar
 Source    Escherichia Coli.
 Physical Appearance    Sterile Filtered clear solution.
Section Bar
 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SELPLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for SELPLG recombinant protein

   Introduction:
SELPLG glycoprotein functions as a high affinity counter-receptor for the cell adhesion selectin molecules (P, E and L) located in stimulated T lymphocytes and myeloid cells. SELPLG binds leukocytes to activated platelets or endothelia expressing selectins, a vital role in leukocyte trafficking throughout inflammation. In order to have a high-affinity binding activity SELPLG needs two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans. Polymorphisms and abnormal expression of SELPLG are linked to defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Description:
SELPLG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 103 amino acids (42-121) and having a molecular mass of 10.9 kDa (Molecular size on SDS-PAGE will appear higher). SELPLG is fused to a 23 amino acid His-tag at N-terminus.
 Product Categories/Family for SELPLG recombinant protein    RECOMBINANT & NATURAL PROTEINS
NCBI/Uniprot data below describe general gene information for SELPLG. It may not necessarily be applicable to this product.
 NCBI GI #    20987422
 NCBI GeneID    6404
 NCBI Accession #    AAH29782.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q12775; Q6GTW7; Q8N7J7; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6 [Other Products]
 UniProt Related Accession #    Q14242 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    Selectin P ligand
 NCBI Official Synonym Full Names    selectin P ligand
 NCBI Official Symbol    SELPLG [Similar Products]
 NCBI Official Synonym Symbols   
CLA; CD162; PSGL1; PSGL-1
[Similar Products]
 NCBI Protein Information    P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen
 UniProt Protein Name    P-selectin glycoprotein ligand 1
 UniProt Synonym Protein Names   
Selectin P ligand; CD_antigen: CD162
 Protein Family    P-selectin glycoprotein ligand
 UniProt Gene Name    SELPLG [Similar Products]
 UniProt Synonym Gene Names    PSGL-1 [Similar Products]
 UniProt Entry Name    SELPL_HUMAN
Section Bar
 NCBI Summary for SELPLG    This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Section Bar
 UniProt Comments for SELPLG    SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell adhesion; blood coagulation; leukocyte tethering or rolling; leukocyte migration; leukocyte adhesive activation
Table BarTOPTable Bar
 Research Articles on SELPLG    1. Up-regulation of PSGL-1 on CD14++CD16+ monocytes may play a crucial role in plaque rupture and thrombus formation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SELPLG recombinant proteinPathways associated with SELPLG recombinant protein
 Reference Product  PubMed Publications
 SELP recombinant protein  >6 publications with SELPLG and SELP
 SYK recombinant protein  >1 publications with SELPLG and SYK
 SELL recombinant protein  >1 publications with SELPLG and SELL
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with SELPLG recombinant proteinOrgans/Tissues associated with SELPLG recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >7 publications with SELPLG and Cardiovascular Diseases
 Heart Diseases Antibodies  >4 publications with SELPLG and Heart Diseases
 Atherosclerosis Antibodies  >4 publications with SELPLG and Atherosclerosis
 Inflammation Antibodies  >2 publications with SELPLG and Inflammation
 Hypertension Antibodies  >1 publications with SELPLG and Hypertension
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with SELPLG and Diabetes Mellitus, Type 2
 Neurobehavioral Manifestations Antibodies  >1 publications with SELPLG and Neurobehavioral Manifestations
 Myocardial Infarction Antibodies  >1 publications with SELPLG and Myocardial Infarction
 Neoplasms, Experimental Antibodies  >1 publications with SELPLG and Neoplasms, Experimental
 Necrosis Antibodies  >1 publications with SELPLG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with SELPLG and Blood
 Bone Antibodies  >2 publications with SELPLG and Bone
 Heart Antibodies  >2 publications with SELPLG and Heart
 Bone Marrow Antibodies  >2 publications with SELPLG and Bone Marrow
 Placenta Antibodies  >2 publications with SELPLG and Placenta
 Embryonic Tissue Antibodies  >2 publications with SELPLG and Embryonic Tissue
 Lung Antibodies  >1 publications with SELPLG and Lung
 Spleen Antibodies  >1 publications with SELPLG and Spleen
 Brain Antibodies  >1 publications with SELPLG and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions