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SEMA4D recombinant protein :: Semaphorin 4D Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2029698 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $255 +1 FREE 8GB USB
0.1 mg  /  $390 +1 FREE 8GB USB
0.2 mg  /  $480 +1 FREE 8GB USB
0.5 mg  /  $935 +1 FREE 8GB USB
1 mg  /  $1,380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Semaphorin 4D (SEMA4D), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Semaphorin 4D (SEMA4D)

 Product Gene Name   

SEMA4D recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Semaphorin 4D (MBS2027737)
Antigen: Semaphorin 4D (MBS2029698)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHS G S-FCGKHGTC E DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVF
 OMIM    601866
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
 Concentration    8.8 (lot specific)
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 Predicted Molecular Mass    16.2kDa
 Accurate Molecular Mass (KD)    18kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    N-terminal His-Tag
 Organism Species    Homo sapiens (Human)
 Fragment    Ala24~Asn92
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of SEMA4D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for SEMA4D recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of SEMA4D recombinant protein    SEMA4D recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SEMA4D. It may not necessarily be applicable to this product.
 NCBI GI #    214010218
 NCBI GeneID    10507
 NCBI Accession #    NP_006369.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006378.3 [Other Products]
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 UniProt Secondary Accession #    Q7Z5S4; Q8N8B0; B2RPM6 [Other Products]
 UniProt Related Accession #    Q92854 [Other Products]
 Molecular Weight    82,164 Da
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 NCBI Official Full Name    semaphorin-4D isoform 1
 NCBI Official Synonym Full Names    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 NCBI Official Symbol    SEMA4D [Similar Products]
 NCBI Official Synonym Symbols   
CD100; SEMAJ; coll-4; C9orf164; M-sema-G
[Similar Products]
 NCBI Protein Information    semaphorin-4D
 UniProt Protein Name    Semaphorin-4D
 UniProt Synonym Protein Names   
A8; BB18; GR3; CD_antigen: CD100
 Protein Family    Semaphorin
 UniProt Gene Name    SEMA4D [Similar Products]
 UniProt Synonym Gene Names    C9orf164; CD100; SEMAJ [Similar Products]
 UniProt Entry Name    SEM4D_HUMAN
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 UniProt Comments for SEMA4D    SEMA4D: a single-pass type I membrane protein that my play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability in vitro.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor activity; semaphorin receptor binding; receptor binding

Biological Process: axon guidance; negative regulation of peptidyl-tyrosine phosphorylation; regulation of dendrite morphogenesis; negative regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of osteoblast differentiation; immune response; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of collateral sprouting; regulation of cell projection organization and biogenesis; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on SEMA4D    1. A positive feedback loop involving sSema4D/IL-6 and TNFalpha/ADAMTS-4 may contribute to the pathogenesis of rheumatoid arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SEMA4D recombinant proteinPathways associated with SEMA4D recombinant protein
 Reference Product  PubMed Publications
 PLXNB1 recombinant protein  >70 publications with SEMA4D and PLXNB1
 CD72 recombinant protein  >36 publications with SEMA4D and CD72
 RHOA recombinant protein  >21 publications with SEMA4D and RHOA
 MET recombinant protein  >18 publications with SEMA4D and MET
 RND1 recombinant protein  >4 publications with SEMA4D and RND1
 RRAS recombinant protein  >3 publications with SEMA4D and RRAS
 ARHGEF12 recombinant protein  >2 publications with SEMA4D and ARHGEF12
 ARHGEF11 recombinant protein  >2 publications with SEMA4D and ARHGEF11
 ARHGAP35 recombinant protein  >1 publications with SEMA4D and ARHGAP35
 PLXNB2 recombinant protein  >1 publications with SEMA4D and PLXNB2
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
 Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies  Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
 Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway antibodies  Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with SEMA4D recombinant proteinOrgans/Tissues associated with SEMA4D recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with SEMA4D and Nervous System Diseases
 Neovascularization, Pathologic Antibodies  >14 publications with SEMA4D and Neovascularization, Pathologic
 Inflammation Antibodies  >13 publications with SEMA4D and Inflammation
 Disease Models, Animal Antibodies  >11 publications with SEMA4D and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >9 publications with SEMA4D and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >6 publications with SEMA4D and Breast Neoplasms
 Kidney Diseases Antibodies  >4 publications with SEMA4D and Kidney Diseases
 Atherosclerosis Antibodies  >4 publications with SEMA4D and Atherosclerosis
 Necrosis Antibodies  >4 publications with SEMA4D and Necrosis
 Lung Diseases Antibodies  >3 publications with SEMA4D and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >98 publications with SEMA4D and Nerve
 Blood Antibodies  >81 publications with SEMA4D and Blood
 Brain Antibodies  >33 publications with SEMA4D and Brain
 Embryonic Tissue Antibodies  >17 publications with SEMA4D and Embryonic Tissue
 Skin Antibodies  >9 publications with SEMA4D and Skin
 Spinal Cord Antibodies  >8 publications with SEMA4D and Spinal Cord
 Kidney Antibodies  >7 publications with SEMA4D and Kidney
 Lymph Node Antibodies  >7 publications with SEMA4D and Lymph Node
 Lung Antibodies  >6 publications with SEMA4D and Lung
 Liver Antibodies  >5 publications with SEMA4D and Liver
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