NP_002766.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,287 Da
NCBI Official Full Name
serine protease HTRA1
NCBI Official Synonym Full Names
HtrA serine peptidase 1
NCBI Official Synonym Symbols
L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; CADASIL2 [Similar Products]
NCBI Protein Information
serine protease HTRA1
UniProt Protein Name
Serine protease HTRA1
UniProt Synonym Protein Names
High-temperature requirement A serine peptidase 1; L56; Serine protease 11
UniProt Synonym Gene Names
NCBI Summary for HTRA1
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
UniProt Comments for HTRA1
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Research Articles on HTRA1
Precautions
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Products associated with HTRA1 recombinant protein
Pathways associated with HTRA1 recombinant protein
Diseases associated with HTRA1 recombinant protein
Organs/Tissues associated with HTRA1 recombinant protein
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