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AGXT recombinant protein :: Serine--pyruvate aminotransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962305
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $910 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,225 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,290 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,385 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,900 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,955 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,110 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,505 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine--pyruvate aminotransferase (AGXT), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Serine--pyruvate aminotransferase

 Product Synonym Names    Alanine-glyoxylate aminotransferase (EC:2.6.1.44); AGT
 Product Gene Name   

AGXT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-392aa; Full Length
 Sequence    MASHKLLVTP PKALLKPLSI PNQLLLGPGP SNLPPRIMAA GGLQMIGSMS KDMYQIMDEI KEGIQYVFQT RNPLTLVISG SGHCALEAAL VNVLEPGDSF LVGANGIWGQ RAVDIGERIG ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL LFLTHGESST GVLQPLDGFG ELCHRYKCLL LVDSVASLGG TPLYMDRQGI DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF YLDIKWLANF WGCDDQPRMY HHTIPVISLY SLRESLALIA EQGLENSWRQ HREAAAYLHG RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVI DHFDIEIMGG LGPSTGKVLR IGLLGCNATR ENVDRVTEAL RAALQHCPKK KL
 OMIM    259900
 3D Structure    ModBase 3D Structure for P21549
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AGXT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AGXT purchase    Serine pyruvate aminotransferase AGXT or SPT has tissue restricted expression. This enzyme and gene expression pattern is localized specifically to peroxisomes where it detoxifies byproducts of oxidative phosphorylation metabolism like glyoxylate by removing alanine. To further understand liver detoxification or to use in cell assay types, MyBiosource offers a human AGXT alanine glyoxylate aminotransferase in multiple tagged recombinant protein forms. Like all our recombinant proteins from Creative Biomart, you can chose your expression vector with confidence. All are genome sequence verified from conserved domain plasmids and highly purified after protein production. Our recombinant human protein resources take the guesswork out of your lab. AGT pyruvate alanine DNA is confirmed with genome workbench alignment tool BLAST, so you know any antibody generated will be robust and ready to validate. To find out about additional applications such as data generation with chemical AMP bioassays, go to MyBiosource.com today.
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 Product Categories/Family for AGXT recombinant protein    Signal Transduction
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 SDS-PAGE of AGXT recombinant protein    AGXT recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for AGXT. It may not necessarily be applicable to this product.
 NCBI GI #    4557289
 NCBI GeneID    189
 NCBI Accession #    NP_000021.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000030.2 [Other Products]
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 UniProt Primary Accession #    P21549 [Other Products]
 UniProt Secondary Accession #    Q53QU6 [Other Products]
 UniProt Related Accession #    P21549 [Other Products]
 Molecular Weight    47.08kD
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 NCBI Official Full Name    serine--pyruvate aminotransferase
 NCBI Official Synonym Full Names    alanine-glyoxylate aminotransferase
 NCBI Official Symbol    AGXT [Similar Products]
 NCBI Official Synonym Symbols   
AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1
[Similar Products]
 NCBI Protein Information    serine--pyruvate aminotransferase
 UniProt Protein Name    Serine--pyruvate aminotransferase
 UniProt Synonym Protein Names   
Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT
 Protein Family    Serine--pyruvate aminotransferase
 UniProt Gene Name    AGXT [Similar Products]
 UniProt Synonym Gene Names    AGT1; SPAT; SPT; AGT [Similar Products]
 UniProt Entry Name    SPYA_HUMAN
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 NCBI Summary for AGXT    This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGXT    AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: EC 2.6.1.44; Motility/polarity/chemotaxis; Transferase; EC 2.6.1.51; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: mitochondrial matrix; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

Disease: Hyperoxaluria, Primary, Type I
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Product References and Citations for AGXT recombinant protein

   Cloning and nucleotide sequence of cDNA encoding human liver serine-pyruvate aminotransferase.Nishiyama K., Berstein G., Oda T., Ichiyama A.Eur. J. Biochem. 194:9-18(1990) Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1.Purdue P.E., Takada Y., Danpure C.J.J. Cell Biol. 111:2341-2351(1990) Human peroxisomal L-alanine glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon.Takada Y., Kaneko N., Esumi H., Purdue P.E., Danpure C.J.Biochem. J. 268:517-520(1990) Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.Purdue P.E., Lumb M.J., Fox M., Griffo G., Hamon-Benais C., Povey S., Danpure C.J.Genomics 10:34-42(1991) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Generation and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.Nature 434:724-731(2005)
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 Research Articles on AGXT    1. In conclusion, this study of an unprecedented number of primary hyperoxaluria type 1 patients showed geno-phenotype associations that have not been previously reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGXT recombinant proteinPathways associated with AGXT recombinant protein
 Reference Product  PubMed Publications
 GRHPR recombinant protein  >13 publications with AGXT and GRHPR
 GLDC recombinant protein  >1 publications with AGXT and GLDC
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
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 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate Metabolism And Glycine Degradation Pathway antibodies  Glyoxylate Metabolism And Glycine Degradation Pathway Diagram
Diseases associated with AGXT recombinant proteinOrgans/Tissues associated with AGXT recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >76 publications with AGXT and Kidney Diseases
 Primary hyperoxaluria type 1 Antibodies  >63 publications with AGXT and Primary hyperoxaluria type 1
 Liver Diseases Antibodies  >7 publications with AGXT and Liver Diseases
 Hypertension Antibodies  >3 publications with AGXT and Hypertension
 Neoplasms, Experimental Antibodies  >3 publications with AGXT and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >3 publications with AGXT and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with AGXT and Cardiovascular Diseases
 Neurotoxicity Syndromes Antibodies  >1 publications with AGXT and Neurotoxicity Syndromes
 Poisoning Antibodies  >1 publications with AGXT and Poisoning
 Fatty Liver Antibodies  >1 publications with AGXT and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >46 publications with AGXT and Liver
 Kidney Antibodies  >41 publications with AGXT and Kidney
 Blood Antibodies  >11 publications with AGXT and Blood
 Intestine Antibodies  >2 publications with AGXT and Intestine
 Brain Antibodies  >1 publications with AGXT and Brain
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