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LATS1 recombinant protein :: Serine/threonine-protein kinase LATS1 (LATS1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1099746 LATS1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,200 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,425 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,425 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,910 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,910 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,365 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,365 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase LATS1 (LATS1), Recombinant Protein

 Also Known As   

Recombinant Human Serine/threonine-protein kinase LATS1 (LATS1) , partial

 Product Gene Name   

LATS1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603473
 3D Structure    ModBase 3D Structure for O95835
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of LATS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LATS1 recombinant protein

   This protein is a putative serine
threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2
cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
NCBI/Uniprot data below describe general gene information for LATS1. It may not necessarily be applicable to this product.
 NCBI GI #    395394049
 NCBI GeneID    9113
 NCBI Accession #    NP_001257448.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270519.1 [Other Products]
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 UniProt Primary Accession #    O95835 [Other Products]
 UniProt Secondary Accession #    Q6PKD0 [Other Products]
 UniProt Related Accession #    O95835 [Other Products]
 Molecular Weight    76,193 Da
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 NCBI Official Full Name    serine/threonine-protein kinase LATS1 isoform 2
 NCBI Official Synonym Full Names    large tumor suppressor kinase 1
 NCBI Official Symbol    LATS1 [Similar Products]
 NCBI Official Synonym Symbols   
wts; WARTS
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase LATS1
 UniProt Protein Name    Serine/threonine-protein kinase LATS1
 UniProt Synonym Protein Names   
Large tumor suppressor homolog 1; WARTS protein kinase; h-warts
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    LATS1 [Similar Products]
 UniProt Synonym Gene Names    h-warts [Similar Products]
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 NCBI Summary for LATS1    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
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 UniProt Comments for LATS1    Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
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 Research Articles on LATS1    1. LATS1/2 signaling via the Hippo pathway regulates human megakaryocytic differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LATS1 recombinant proteinPathways associated with LATS1 recombinant protein
 Reference Product  PubMed Publications
 STK3 recombinant protein  >19 publications with LATS1 and STK3
 STK4 recombinant protein  >9 publications with LATS1 and STK4
 LIMK1 recombinant protein  >4 publications with LATS1 and LIMK1
 ZYX recombinant protein  >1 publications with LATS1 and ZYX
 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram
Diseases associated with LATS1 recombinant proteinOrgans/Tissues associated with LATS1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms, Glandular and Epithelial Antibodies  >13 publications with LATS1 and Neoplasms, Glandular and Epithelial
 Nervous System Diseases Antibodies  >6 publications with LATS1 and Nervous System Diseases
 Chromosome Aberrations Antibodies  >6 publications with LATS1 and Chromosome Aberrations
 Neoplasm Metastasis Antibodies  >4 publications with LATS1 and Neoplasm Metastasis
 Abnormalities, Multiple Antibodies  >3 publications with LATS1 and Abnormalities, Multiple
 Embryo Loss Antibodies  >2 publications with LATS1 and Embryo Loss
 Hypertrophy Antibodies  >2 publications with LATS1 and Hypertrophy
 Neurodegenerative Diseases Antibodies  >2 publications with LATS1 and Neurodegenerative Diseases
 Astrocytoma Antibodies  >2 publications with LATS1 and Astrocytoma
 Eye Abnormalities Antibodies  >1 publications with LATS1 and Eye Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with LATS1 and Liver
 Lung Antibodies  >10 publications with LATS1 and Lung
 Eye Antibodies  >8 publications with LATS1 and Eye
 Kidney Antibodies  >7 publications with LATS1 and Kidney
 Embryonic Tissue Antibodies  >5 publications with LATS1 and Embryonic Tissue
 Prostate Antibodies  >5 publications with LATS1 and Prostate
 Brain Antibodies  >5 publications with LATS1 and Brain
 Lymph Node Antibodies  >4 publications with LATS1 and Lymph Node
 Muscle Antibodies  >4 publications with LATS1 and Muscle
 Blood Antibodies  >3 publications with LATS1 and Blood
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