Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Pak1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • AKT (AKT1) Blocking Peptide
 • (Rhesus macaque) Myeloid differentiation primary response pr... Recombinant Protein
 • HA Antibody
 • Rat IgG2b Isotype Control Isotype Control
 • WWP1 cDNA Clone
 • SLC2A5 cDNA Clone
 • CSF1R Antibody
 • Target of rapamycin complex 2 subunit MAPKAP1 Recombinant Protein
 • PPP2CA - PPP2CB Peptide
 • Prostate Specific Antigen (PSA) ACT Complex >95% Pure (KLK3) Native Protein
 • Cathepsin G (CTSG) Protein
 • 2,3-Bisphosphoglycerate (2,3-BPG) ELISA Kit
 • Blebbistatin Inhibitor
 • ETAR Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Pak1 recombinant protein :: Serine/threonine-protein kinase PAK 1 (Pak1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948667 Pak1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $970 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,035 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,295 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,400 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,430 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,475 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,585 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,035 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,110 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,125 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,410 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,770 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase PAK 1 (Pak1), Recombinant Protein

 Also Known As   

Recombinant Rat Serine/threonine-protein kinase PAK 1 (Pak1)

 Product Synonym Names    Serine/threonine-protein kinase PAK 1; EC=2.7.11.1; Alpha-PAK; Protein kinase MUK2; p21-activated kinase 1; PAK-1; p68-PAK
 Product Gene Name   

Pak1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    2-544aa; Full length protein
 Sequence    SNNGLDVQD KPPAPPMRNT STMIGAGSKD PGTLNHGSKP LPPNPEEKKK KDRFYRSILA GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNTLN VKTVSETPAV PPVSEDEDDD DDATPPPVIA PRPEHTKSVY TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS LTDVVTETCM DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS AIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT KNNH
 3D Structure    ModBase 3D Structure for P35465
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Rattus norvegicus (Rat)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pak1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for Pak1 recombinant protein

   PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Pak1. It may not necessarily be applicable to this product.
 NCBI GI #    8393901
 NCBI GeneID    29431
 NCBI Accession #    NP_058894.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017198.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P35465 [Other Products]
 UniProt Secondary Accession #    Q62934 [Other Products]
 UniProt Related Accession #    P35465 [Other Products]
 Molecular Weight    60,578 Da
Table BarTOPTable Bar
 NCBI Official Full Name    serine/threonine-protein kinase PAK 1
 NCBI Official Synonym Full Names    p21 protein (Cdc42/Rac)-activated kinase 1
 NCBI Official Symbol    Pak1 [Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase PAK 1; PAK-1; p68-PAK; alpha-PAK; protein kinase MUK2; p21-activated kinase 1; p21 (CDKN1A)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
 UniProt Protein Name    Serine/threonine-protein kinase PAK 1
 UniProt Synonym Protein Names   
Alpha-PAK; Protein kinase MUK2; p21-activated kinase 1; PAK-1; p68-PAK
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    Pak1 [Similar Products]
 UniProt Synonym Gene Names    PAK-1 [Similar Products]
 UniProt Entry Name    PAK1_RAT
Section Bar
 NCBI Summary for Pak1    serine/threonine protein kinase; binds and forms complex specifically with activated (GTP-bound) p21, leading to inhibiting p21 GTPase activity [RGD, Feb 2006]
Section Bar
 UniProt Comments for Pak1    PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKA subfamily

Cellular Component: Golgi apparatus; nuclear membrane; focal adhesion; protein complex; dendrite; intercellular junction; cytosol; Z disc; ruffle; growth cone; membrane; axon; cytoplasm; plasma membrane; nucleus

Molecular Function: collagen binding; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: positive regulation of JNK activity; exocytosis; activation of MAPKK activity; wound healing; apoptosis; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; protein amino acid phosphorylation; receptor clustering; response to organic substance; small GTPase mediated signal transduction; positive regulation of stress fiber formation; dendrite development; neuromuscular junction development; MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; branching morphogenesis of a tube; cellular response to insulin stimulus; axonogenesis; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; response to hypoxia; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; neurite morphogenesis
Table BarTOPTable Bar
 Research Articles on Pak1    1. Describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1, and phosphorylation of cortactin, causes invadopodia dissolution.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with Pak1 recombinant proteinPathways associated with Pak1 recombinant protein
 Reference Product  PubMed Publications
 Cdc42 recombinant protein  >299 publications with Pak1 and Cdc42
 Rac1 recombinant protein  >266 publications with Pak1 and Rac1
 Limk1 recombinant protein  >44 publications with Pak1 and Limk1
 Arhgef7 recombinant protein  >12 publications with Pak1 and Arhgef7
 Rac2 recombinant protein  >12 publications with Pak1 and Rac2
 Grb2 recombinant protein  >11 publications with Pak1 and Grb2
 Fyn recombinant protein  >5 publications with Pak1 and Fyn
 Raf1 recombinant protein  >4 publications with Pak1 and Raf1
 Mapk14 recombinant protein  >1 publications with Pak1 and Mapk14
 Nck1 recombinant protein  >1 publications with Pak1 and Nck1
 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
Diseases associated with Pak1 recombinant proteinOrgans/Tissues associated with Pak1 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >74 publications with Pak1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >32 publications with Pak1 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >32 publications with Pak1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >28 publications with Pak1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >25 publications with Pak1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >23 publications with Pak1 and Neoplasms, Experimental
 Inflammation Antibodies  >19 publications with Pak1 and Inflammation
 Necrosis Antibodies  >17 publications with Pak1 and Necrosis
 Liver Neoplasms Antibodies  >15 publications with Pak1 and Liver Neoplasms
 Liver Diseases Antibodies  >15 publications with Pak1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with Pak1 and Brain
 Muscle Antibodies  >73 publications with Pak1 and Muscle
 Artery Antibodies  >28 publications with Pak1 and Artery
 Colon Antibodies  >22 publications with Pak1 and Colon
 Prostate Antibodies  >21 publications with Pak1 and Prostate
 Ovary Antibodies  >6 publications with Pak1 and Ovary
 Eye Antibodies  >4 publications with Pak1 and Eye
 Placenta Antibodies  >3 publications with Pak1 and Placenta
 Connective Tissue Antibodies  >2 publications with Pak1 and Connective Tissue
 Spleen Antibodies  >2 publications with Pak1 and Spleen
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions