Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Stk11  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • N Acetylgalactosamine 6 Sulfatase (GAS) ELISA Kit
 • ITAC Recombinant Protein
 • Fibroblast Growth Factor 15 (FGF15) Antibody
 • MART-1 - Melan-A - MLANA Antibody
 • M-phase inducer phosphatase 1 (CDC25A) Recombinant Protein
 • Actin-like protein 6A (ACTL6A) Antibody
 • Interleukin 8 (IL8) ELISA Kit
 • Thymic stromal lymphopoietin (TSLP) Recombinant Protein
 • Deoxyribonuclease I (DNASE1) ELISA Kit
 • Procollagen III N-Terminal Propeptide (PIIINP) Antibody
 • NPHS1 Antibody
 • FAS Ligand (FASL) ELISA Kit
 • Desmosine ELISA Kit
 • CD107a (LAMP-1) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Stk11 recombinant protein :: Serine/threonine-protein kinase STK11 (Stk11) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1387197 Stk11 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $850 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,135 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,255 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,275 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,320 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,780 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,000 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,190 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase STK11 (Stk11), Recombinant Protein

 Also Known As   

Recombinant Mouse Serine/threonine-protein kinase STK11 (Stk11)

 Product Gene Name   

Stk11 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Stk11 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    1-433aa, full length protein
 Sequence    MDVADPEPLG LFSEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHRNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFRQL IDGLEYLHSQ GIVHKDIKPG NLLLTTNGTL KISDLGVAEA LHPFAVDDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT GLYPFEGDNI YKLFENIGRG DFTIPCDCGP PLSDLLRGML EYEPAKRFSI RQIRQHSWFR KKHPLAEALV PIPPSPDTKD RWRSMTVVPY LEDLHGRAEE EEEEDLFDIE DGIIYTQDFT VPGQVLEEEV GQNGQSHSLP KAVCVNGTEP QLSSKVKPEG RPGTANPARK VCSSNKIRRL SAC
 3D Structure    ModBase 3D Structure for Q9WTK7
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Stk11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for Stk11 recombinant protein

   This gene, which encodes a member of the serine
threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
NCBI/Uniprot data below describe general gene information for Stk11. It may not necessarily be applicable to this product.
 NCBI GI #    687569592
 NCBI GeneID    20869
 NCBI Accession #    NP_001288782.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001301853.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9WTK7 [Other Products]
 UniProt Secondary Accession #    Q3TAE0; B3VBP0 [Other Products]
 UniProt Related Accession #    Q9WTK7 [Other Products]
 Molecular Weight    46,494 Da
Table BarTOPTable Bar
 NCBI Official Full Name    serine/threonine-protein kinase STK11 isoform S
 NCBI Official Synonym Full Names    serine/threonine kinase 11
 NCBI Official Symbol    Stk11 [Similar Products]
 NCBI Official Synonym Symbols   
Lkb1; Par-4; R75140; AA408040
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase STK11
 UniProt Protein Name    Serine/threonine-protein kinase STK11
 UniProt Synonym Protein Names   
Liver kinase B1 homolog; LKB1; mLKB1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    Stk11 [Similar Products]
 UniProt Synonym Gene Names    LKB1; mLKB1 [Similar Products]
Section Bar
 NCBI Summary for Stk11    This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Section Bar
 UniProt Comments for Stk11    Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
Table BarTOPTable Bar
 Research Articles on Stk11    1. The metabolic effects were associated with activation of the SIRT1-LKB1-AMPK signalling pathway in adipose tissue and liver.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with Stk11 recombinant proteinPathways associated with Stk11 recombinant protein
 Reference Product  PubMed Publications
 Tsc2 recombinant protein  >29 publications with Stk11 and Tsc2
 Prkaa1 recombinant protein  >21 publications with Stk11 and Prkaa1
 Prkaa2 recombinant protein  >13 publications with Stk11 and Prkaa2
 Foxo3 recombinant protein  >7 publications with Stk11 and Foxo3
 Prkag2 recombinant protein  >3 publications with Stk11 and Prkag2
 Cab39 recombinant protein  >3 publications with Stk11 and Cab39
 Cab39l recombinant protein  >2 publications with Stk11 and Cab39l
 Strada recombinant protein  >1 publications with Stk11 and Strada
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 Focal Adhesion-PI3K-Akt-mTOR-signaling Pathway antibodies  Focal Adhesion-PI3K-Akt-mTOR-signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
Diseases associated with Stk11 recombinant proteinOrgans/Tissues associated with Stk11 recombinant protein
 Disease Name  Pubmed Publications
 Peutz-Jeghers Syndrome Antibodies  >405 publications with Stk11 and Peutz-Jeghers Syndrome
 Intestinal Polyposis Antibodies  >278 publications with Stk11 and Intestinal Polyposis
 Lung Neoplasms Antibodies  >183 publications with Stk11 and Lung Neoplasms
 Adenocarcinoma Antibodies  >166 publications with Stk11 and Adenocarcinoma
 Liver Neoplasms Antibodies  >85 publications with Stk11 and Liver Neoplasms
 Disease Models, Animal Antibodies  >83 publications with Stk11 and Disease Models, Animal
 Liver Diseases Antibodies  >60 publications with Stk11 and Liver Diseases
 Pancreatic Neoplasms Antibodies  >51 publications with Stk11 and Pancreatic Neoplasms
 Neoplasms, Experimental Antibodies  >50 publications with Stk11 and Neoplasms, Experimental
 Fatty Liver Antibodies  >46 publications with Stk11 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >261 publications with Stk11 and Liver
 Lung Antibodies  >222 publications with Stk11 and Lung
 Muscle Antibodies  >125 publications with Stk11 and Muscle
 Brain Antibodies  >61 publications with Stk11 and Brain
 Heart Antibodies  >47 publications with Stk11 and Heart
 Pancreas Antibodies  >43 publications with Stk11 and Pancreas
 Intestine Antibodies  >39 publications with Stk11 and Intestine
 Stomach Antibodies  >31 publications with Stk11 and Stomach
 Skin Antibodies  >24 publications with Stk11 and Skin
 Kidney Antibodies  >21 publications with Stk11 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions