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Stk11 recombinant protein :: Serine/threonine-protein kinase STK11 (Stk11) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1387197 Stk11 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $850 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $945 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,075 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,135 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,255 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,275 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,320 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,365 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,780 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,955 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,000 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,190 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,580 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase STK11 (Stk11), Recombinant Protein

 Also Known As   

Recombinant Mouse Serine/threonine-protein kinase STK11 (Stk11)

 Product Synonym Names    Serine/threonine-protein kinase STK11; EC=2.7.11.1; Liver kinase B1 homolog; LKB1; mLKB1
 Product Gene Name   

Stk11 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Stk11; Lkb1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-433. Mature full length protein.
 Sequence    MDVADPEPLG LFSEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHRNV IQLVDVLYNE EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFRQL IDGLEYLHSQ GIVHKDIKPG NLLLTTNGTL KISDLGVAEA LHPFAVDDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS AGVTLYNITT GLYPFEGDNI YKLFENIGRG DFTIPCDCGP PLSDLLRGML EYEPAKRFSI RQIRQHSWFR KKHPLAEALV PIPPSPDTKD RWRSMTVVPY LEDLHGRAEE EEEEDLFDIE DGIIYTQDFT VPGQVLEEEV GQNGQSHSLP KAVCVNGTEP QLSSKVKPEG RPGTANPARK VCSSNKIRRL SAC
 3D Structure    ModBase 3D Structure for Q9WTK7
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Stk11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Stk11. It may not necessarily be applicable to this product.
 NCBI GI #    7106425
 NCBI GeneID    20869
 NCBI Accession #    NP_035622.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011492.4 [Other Products]
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 UniProt Primary Accession #    Q9WTK7 [Other Products]
 UniProt Secondary Accession #    Q3TAE0; B3VBP0 [Other Products]
 UniProt Related Accession #    Q9WTK7 [Other Products]
 Molecular Weight    46,494 Da
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 NCBI Official Full Name    serine/threonine-protein kinase STK11 isoform L
 NCBI Official Synonym Full Names    serine/threonine kinase 11
 NCBI Official Symbol    Stk11 [Similar Products]
 NCBI Official Synonym Symbols   
Lkb1; Par-4; R75140; AA408040
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase STK11; liver kinase B1 homolog; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1
 UniProt Protein Name    Serine/threonine-protein kinase STK11
 UniProt Synonym Protein Names   
Liver kinase B1 homolog; LKB1; mLKB1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    Stk11 [Similar Products]
 UniProt Synonym Gene Names    LKB1; mLKB1 [Similar Products]
 UniProt Entry Name    STK11_MOUSE
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 NCBI Summary for Stk11    This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
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 UniProt Comments for Stk11    LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

Protein type: Protein kinase, CAMK; Autophagy; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Tumor suppressor; EC 2.7.11.1; CAMK group; CAMKL family; LKB subfamily

Cellular Component: protein complex; membrane; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: p53 binding; metal ion binding; magnesium ion binding; nucleotide binding; LRR domain binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; protein kinase activator activity; ATP binding

Biological Process: Golgi localization; protein heterooligomerization; apoptosis; regulation of dendrite morphogenesis; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; response to lipid; T cell receptor signaling pathway; protein amino acid phosphorylation; anoikis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; vasculature development; tissue homeostasis; regulation of cell growth; cell differentiation; cell cycle arrest; positive thymic T cell selection; regulation of Wnt receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein kinase B signaling cascade; cell cycle; positive regulation of peptidyl-tyrosine phosphorylation; axonogenesis; establishment of cell polarity; positive regulation of protein kinase activity; activation of protein kinase activity; autophagy; positive regulation of axonogenesis; spermatogenesis; response to ionizing radiation; negative regulation of cell growth; phosphorylation; response to DNA damage stimulus; spermatid development
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 Research Articles on Stk11    1. Findings indicate that LKB1 plays a crucial role in regulating AMPKalpha2 activation and acetyl-CoA carboxylase-2 phosphorylation and also in regulating cellular energy levels in response to ischemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Stk11 recombinant proteinPathways associated with Stk11 recombinant protein
 Reference Product  PubMed Publications
 Nuak2 recombinant protein  >4 publications with Stk11 and Nuak2
 Products by Pathway  Pathway Diagram
 AMPK Inhibits ChREBP Transcriptional Activation Activity Pathway antibodies  AMPK Inhibits ChREBP Transcriptional Activation Activity Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 PI3K Cascade Pathway antibodies  PI3K Cascade Pathway Diagram
Diseases associated with Stk11 recombinant proteinOrgans/Tissues associated with Stk11 recombinant protein
 Disease Name  Pubmed Publications
 Peutz-Jeghers Syndrome Antibodies  >311 publications with Stk11 and Peutz-Jeghers Syndrome
 Intestinal Polyposis Antibodies  >220 publications with Stk11 and Intestinal Polyposis
 Melanosis Antibodies  >219 publications with Stk11 and Melanosis
 Carcinoma Antibodies  >131 publications with Stk11 and Carcinoma
 Lung Neoplasms Antibodies  >76 publications with Stk11 and Lung Neoplasms
 Adenocarcinoma Antibodies  >69 publications with Stk11 and Adenocarcinoma
 Breast Neoplasms Antibodies  >62 publications with Stk11 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >37 publications with Stk11 and Pancreatic Neoplasms
 Liver Diseases Antibodies  >28 publications with Stk11 and Liver Diseases
 Liver Neoplasms Antibodies  >27 publications with Stk11 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >87 publications with Stk11 and Lung
 Liver Antibodies  >77 publications with Stk11 and Liver
 Muscle Antibodies  >69 publications with Stk11 and Muscle
 Brain Antibodies  >32 publications with Stk11 and Brain
 Pancreas Antibodies  >27 publications with Stk11 and Pancreas
 Heart Antibodies  >25 publications with Stk11 and Heart
 Intestine Antibodies  >25 publications with Stk11 and Intestine
 Stomach Antibodies  >15 publications with Stk11 and Stomach
 Testis Antibodies  >15 publications with Stk11 and Testis
 Ovary Antibodies  >15 publications with Stk11 and Ovary
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