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MTOR recombinant protein :: Serine/threonine-protein kinase mTOR (MTOR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952402 MTOR recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $870 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $870 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,095 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,095 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,285 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serine/threonine-protein kinase mTOR (MTOR), Recombinant Protein

 Also Known As   

Recombinant Human Serine/threonine-protein kinase mTOR (MTOR) , partial

 Product Gene Name   

MTOR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2012-2144; Sufficient for interaction with the FKBP1A/rapamycin complex region.
 Sequence    VSEELIRVAI LWHEMWHEGL EEASRLYFGE RNVKGMFEVL EPLHAMMERG PQTLKETSFN QAYGRDLMEA QEWCRKYMKS GNVKDLTQAW DLYYHVFRRI SKQLPQLTSL ELQYVSPKLL MCRDLELAVP GTY
 OMIM    601231
 3D Structure    ModBase 3D Structure for P42345
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MTOR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MTOR recombinant protein

   This protein belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
NCBI/Uniprot data below describe general gene information for MTOR. It may not necessarily be applicable to this product.
 NCBI GI #    4826730
 NCBI GeneID    2475
 NCBI Accession #    NP_004949.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004958.3 [Other Products]
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 UniProt Primary Accession #    P42345 [Other Products]
 UniProt Secondary Accession #    Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3 [Other Products]
 UniProt Related Accession #    P42345 [Other Products]
 Molecular Weight    288,892 Da
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 NCBI Official Full Name    serine/threonine-protein kinase mTOR
 NCBI Official Synonym Full Names    mechanistic target of rapamycin kinase
 NCBI Official Symbol    MTOR [Similar Products]
 NCBI Official Synonym Symbols   
SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase mTOR
 UniProt Protein Name    Serine/threonine-protein kinase mTOR
 UniProt Synonym Protein Names   
FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    MTOR [Similar Products]
 UniProt Synonym Gene Names    FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mTOR [Similar Products]
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 NCBI Summary for MTOR    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for MTOR    Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms ().
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 Research Articles on MTOR    1. Our data indicated that miR-451 relays environmental signals by upregulating the activity of AMPK signaling, thereby modulating the activation of mTOR and Rac1/cofilin which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MTOR recombinant proteinPathways associated with MTOR recombinant protein
 Reference Product  PubMed Publications
 EIF4EBP1 recombinant protein  >444 publications with MTOR and EIF4EBP1
 AKT1 recombinant protein  >342 publications with MTOR and AKT1
 RICTOR recombinant protein  >243 publications with MTOR and RICTOR
 RHEB recombinant protein  >233 publications with MTOR and RHEB
 STAT3 recombinant protein  >155 publications with MTOR and STAT3
 IRS1 recombinant protein  >117 publications with MTOR and IRS1
 RPTOR recombinant protein  >109 publications with MTOR and RPTOR
 RPS6KA1 recombinant protein  >74 publications with MTOR and RPS6KA1
 AKT1S1 recombinant protein  >21 publications with MTOR and AKT1S1
 TERT recombinant protein  >19 publications with MTOR and TERT
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
Diseases associated with MTOR recombinant proteinOrgans/Tissues associated with MTOR recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4311 publications with MTOR and Neoplasms
 Nervous System Diseases Antibodies  >776 publications with MTOR and Nervous System Diseases
 Adenocarcinoma Antibodies  >772 publications with MTOR and Adenocarcinoma
 Kidney Diseases Antibodies  >635 publications with MTOR and Kidney Diseases
 Breast Neoplasms Antibodies  >520 publications with MTOR and Breast Neoplasms
 Drug Toxicity Antibodies  >435 publications with MTOR and Drug Toxicity
 Cardiovascular Diseases Antibodies  >424 publications with MTOR and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >379 publications with MTOR and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >363 publications with MTOR and Lung Neoplasms
 Hypertrophy Antibodies  >336 publications with MTOR and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1270 publications with MTOR and Blood
 Muscle Antibodies  >1066 publications with MTOR and Muscle
 Kidney Antibodies  >1032 publications with MTOR and Kidney
 Vascular Antibodies  >930 publications with MTOR and Vascular
 Brain Antibodies  >893 publications with MTOR and Brain
 Liver Antibodies  >692 publications with MTOR and Liver
 Lung Antibodies  >601 publications with MTOR and Lung
 Heart Antibodies  >430 publications with MTOR and Heart
 Bone Antibodies  >321 publications with MTOR and Bone
 Prostate Antibodies  >309 publications with MTOR and Prostate
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