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SERPING1 recombinant protein :: Serpin Peptidase Inhibitor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145543 SERPING1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,410 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Serpin Peptidase Inhibitor (SERPING1), Recombinant Protein

 Also Known As   

Recombinant Human Serpin Peptidase Inhibitor, Clade G Member 1

 Product Synonym Names    SERPING1 Human; Serpin Peptidase Inhibitor, Clade G Member 1 Human Recombinant; C1IN; C1INH; C1NH; HAE1; HAE2; Plasma protease C1 inhibitor; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1; Name; SERPING1
 Product Gene Name   

SERPING1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    106100
 3D Structure    ModBase 3D Structure for P05155
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    SERPING1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and10% glycerol.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of SERPING1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SERPING1 recombinant protein

   Description: SERPING1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 499 amino acids (23-500a.a) and having a molecular mass of 55.1kDa. SERPING1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Plasma protease C1 inhibitor (SERPING1) is a part of the serpin superfamily of serine protease inhibitors. SERPING1 plays an important role in regulating activation of both the complement and contact systems. That isdue to the fact that SERPING1 regulates the activation of complement factor C1 in addition to the activity of activated C1 by coupling with the active catalytic site at the light chains of C1r and C1s. SERPING1 insufficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa.
 Product Categories/Family for SERPING1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Serpin
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
 NCBI GI #    73858568
 NCBI GeneID    710
 NCBI Accession #    NP_000053.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000062.2 [Other Products]
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 UniProt Primary Accession #    P05155 [Other Products]
 UniProt Secondary Accession #    Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2 [Other Products]
 UniProt Related Accession #    P05155 [Other Products]
 Molecular Weight    55,769 Da
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 NCBI Official Full Name    plasma protease C1 inhibitor
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
 NCBI Official Symbol    SERPING1 [Similar Products]
 NCBI Official Synonym Symbols   
C1IN; C1NH; HAE1; HAE2; C1INH
[Similar Products]
 NCBI Protein Information    plasma protease C1 inhibitor; C1 esterase inhibitor; C1-inhibiting factor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1; serpin G1
 UniProt Protein Name    Plasma protease C1 inhibitor
 UniProt Synonym Protein Names   
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
 Protein Family    Plasma protease C1 inhibitor
 UniProt Gene Name    SERPING1 [Similar Products]
 UniProt Synonym Gene Names    C1IN; C1NH; C1 Inh; C1Inh [Similar Products]
 UniProt Entry Name    IC1_HUMAN
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 NCBI Summary for SERPING1    This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPING1    SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
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 Research Articles on SERPING1    1. A series of 22 different mutations was identified of C1NH gene in Italian patients with hereditary angioedema.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPING1 recombinant proteinDiseases associated with SERPING1 recombinant protein
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Disease Name  Pubmed Publications
 Angioedemas, Hereditary Antibodies  >95 publications with SERPING1 and Angioedemas, Hereditary
 Edema Antibodies  >60 publications with SERPING1 and Edema
 Inflammation Antibodies  >24 publications with SERPING1 and Inflammation
 Hereditary Angioedema Types I and II Antibodies  >17 publications with SERPING1 and Hereditary Angioedema Types I and II
 Acquired angioedema Antibodies  >14 publications with SERPING1 and Acquired angioedema
 Disease Models, Animal Antibodies  >12 publications with SERPING1 and Disease Models, Animal
 Brain Diseases Antibodies  >8 publications with SERPING1 and Brain Diseases
 Necrosis Antibodies  >7 publications with SERPING1 and Necrosis
 Kidney Diseases Antibodies  >5 publications with SERPING1 and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with SERPING1 and Heart Diseases
Organs/Tissues associated with SERPING1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >88 publications with SERPING1 and Blood
 Vascular Antibodies  >28 publications with SERPING1 and Vascular
 Skin Antibodies  >26 publications with SERPING1 and Skin
 Larynx Antibodies  >16 publications with SERPING1 and Larynx
 Eye Antibodies  >9 publications with SERPING1 and Eye
 Heart Antibodies  >6 publications with SERPING1 and Heart
 Kidney Antibodies  >5 publications with SERPING1 and Kidney
 Intestine Antibodies  >5 publications with SERPING1 and Intestine
 Muscle Antibodies  >5 publications with SERPING1 and Muscle
 Liver Antibodies  >5 publications with SERPING1 and Liver
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