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Sry recombinant protein :: Sex-determining region Y protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963769
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $855 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,075 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,090 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,560 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,665 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,085 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sex-determining region Y protein (Sry), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Sex-determining region Y protein

 Product Synonym Names    Testis-determining factor
 Product Gene Name   

Sry recombinant protein

[Similar Products]
 Product Synonym Gene Name    Tdf; Tdy [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-144aa; Partial
 Sequence    MEGHVKRPMN AFMVWSRGER HKLAQQNPSM QNTEISKQLG CRWKSLTEAE KRPFFQEAQR LKILHREKYP NYKYQPHRRA KVSQRSGILQ PAVASTKLYN LLQWDRNPHA ITYRQDWSRA AHLYSKNQQS FYWQPVDIPT GHLQ
 3D Structure    ModBase 3D Structure for Q05738
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Sry recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Sry recombinant protein

   Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. 1 Publication
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 SDS-PAGE of Sry recombinant protein    Sry recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Sry. It may not necessarily be applicable to this product.
 NCBI GI #    6755761
 NCBI GeneID    21674
 NCBI Accession #    NP_035694.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011564.1 [Other Products]
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 UniProt Primary Accession #    Q05738 [Other Products]
 UniProt Related Accession #    Q05738 [Other Products]
 Molecular Weight    21.3kD
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 NCBI Official Full Name    sex-determining region Y protein
 NCBI Official Synonym Full Names    sex determining region of Chr Y
 NCBI Official Symbol    Sry [Similar Products]
 NCBI Official Synonym Symbols   
Tdf; Tdy
[Similar Products]
 NCBI Protein Information    sex-determining region Y protein
 UniProt Protein Name    Sex-determining region Y protein
 UniProt Synonym Protein Names   
Testis-determining factor
 Protein Family    Sex-determining region Y protein
 UniProt Gene Name    Sry [Similar Products]
 UniProt Synonym Gene Names    Tdf; Tdy [Similar Products]
 UniProt Entry Name    SRY_MOUSE
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 UniProt Comments for Sry    SRY: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Defects in SRY are the cause of 46,XY sex reversal type 1 (SRXY1). A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal. A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, streak gonads, variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female. Defects in SRY are the cause of 46,XX sex reversal type 1 (SRXX1). A condition in which male gonads develop in a genetic female (female to male sex reversal). Belongs to the SRY family.

Protein type: DNA-binding; Nuclear receptor co-regulator

Cellular Component: cytoplasm; nucleus

Molecular Function: calmodulin binding; DNA bending activity; DNA binding; protein binding; protein heterodimerization activity; transcription factor activity

Biological Process: cell differentiation; male gonad development; male sex determination; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; sex determination; sex differentiation; transcription, DNA-dependent
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Product References and Citations for Sry recombinant protein

   Inverted repeat structure of the Sry locus in mice.Gubbay J., Vivian N., Economou A., Jackson D., Goodfellow P.Proc. Natl. Acad. Sci. U.S.A. 89:7953-7957(1992) Rapid evolution of the sex determining locus in Old World mice and rats.Tucker P.K., Lundrigan B.L.Nature 364:715-717(1993) Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal.Coward P., Nagai K., Chen D., Thomas H.D., Nagamine C.M., Lau Y.-F.C.Nat. Genet. 6:245-250(1994) A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.Gubbay J., Collignon J., Koopman P., Capel B., Economou A., Munsterberg A., Vivian N., Goodfellow P., Lovell-Badge R.Nature 346:245-250(1990) Definition of a consensus DNA binding site for SRY.Harley V.R., Lovell-Badge R., Goodfellow P.N.Nucleic Acids Res. 22:1500-1501(1994) Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors.Giese K., Pagel J., Grosschedl R.Proc. Natl. Acad. Sci. U.S.A. 91:3368-3372(1994) Expression of Sry, the mouse sex determining gene.Hacker A., Capel B., Goodfellow P., Lovell-Badge R.Development 121:1603-1614(1995) Expression of a linear Sry transcript in the mouse genital ridge.Jeske Y.W., Bowles J., Greenfield A., Koopman P.Nat. Genet. 10:480-482(1995) Developmental profile of Sry transcripts in mouse brain.Mayer A., Mosler G., Just W., Pilgrim C., Reisert I.Neurogenetics 3:25-30(2000) Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.Albrecht K.H., Eicher E.M.Dev. Biol. 240:92-107(2001) The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.Forwood J.K., Harley V., Jans D.A.J. Biol. Chem. 276:46575-46582(2001) Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending comparison of human and murine HMG boxes.Phillips N.B., Nikolskaya T., Jancso-Radek A., Ittah V., Jiang F., Singh R., Haas E., Weiss M.A.Biochemistry 43:7066-7081(2004) Regulation of human SRY subcellular distribution by its acetylation/deacetylation.Thevenet L., Mejean C., Moniot B., Bonneaud N., Galeotti N., Aldrian-Herrada G., Poulat F., Berta P., Benkirane M., Boizet-Bonhoure B.EMBO J. 23:3336-3345(2004) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.Oh H.J., Li Y., Lau Y.-F.C.Biol. Reprod. 72:407-415(2005) NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.Thevenet L., Albrecht K.H., Malki S., Berta P., Boizet-Bonhoure B., Poulat F.J. Biol. Chem. 280:38625-38630(2005) Direct regulation of adult brain function by the male-specific factor SRY.Dewing P., Chiang C.W., Sinchak K., Sim H., Fernagut P.-O., Kelly S., Chesselet M.-F., Micevych P.E., Albrecht K.H., Harley V.R., Vilain E.Curr. Biol. 16:415-420(2006) The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions.Li Y., Oh H.J., Lau Y.-F.C.Mol. Cell. Endocrinol. 257:35-46(2006) Sry and the hesitant beginnings of male development.Polanco J.C., Koopman P.Dev. Biol. 302:13-24(2007) KRAB a partner for SRY action on chromatin.Oh H.J., Lau Y.F.Mol. Cell. Endocrinol. 247:47-52(2006)
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 Research Articles on Sry    1. Sry can be replaced by transgenic activation of its downstream target Sox9. This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Sry recombinant proteinPathways associated with Sry recombinant protein
 Reference Product  PubMed Publications
 Wt1 recombinant protein  >100 publications with Sry and Wt1
 Amh recombinant protein  >56 publications with Sry and Amh
 Nr0b1 recombinant protein  >53 publications with Sry and Nr0b1
 Nr5a1 recombinant protein  >36 publications with Sry and Nr5a1
 Uty recombinant protein  >19 publications with Sry and Uty
 Zfpm2 recombinant protein  >6 publications with Sry and Zfpm2
 Zfy1 recombinant protein  >2 publications with Sry and Zfy1
 Etv2 recombinant protein  >1 publications with Sry and Etv2
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Deactivation Of The Beta-catenin Transactivating Complex Pathway antibodies  Deactivation Of The Beta-catenin Transactivating Complex Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
Diseases associated with Sry recombinant protein
 Disease Name  Pubmed Publications
 Gonadal Dysgenesis Antibodies  >403 publications with Sry and Gonadal Dysgenesis
 Heart Diseases Antibodies  >145 publications with Sry and Heart Diseases
 Nervous System Diseases Antibodies  >87 publications with Sry and Nervous System Diseases
 Disease Models, Animal Antibodies  >73 publications with Sry and Disease Models, Animal
 46,XY SEX REVERSAL 1 Antibodies  >41 publications with Sry and 46,XY SEX REVERSAL 1
 Oligospermia Antibodies  >38 publications with Sry and Oligospermia
 Kidney Diseases Antibodies  >37 publications with Sry and Kidney Diseases
 Liver Diseases Antibodies  >37 publications with Sry and Liver Diseases
 Hyperplasia Antibodies  >36 publications with Sry and Hyperplasia
 46,XX SEX REVERSAL 1 Antibodies  >30 publications with Sry and 46,XX SEX REVERSAL 1
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