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SIGLEC1 recombinant protein :: Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009590 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $330 +1 FREE 8GB USB
0.2 mg  /  $405 +1 FREE 8GB USB
0.5 mg  /  $780 +1 FREE 8GB USB
1 mg  /  $1,150 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1)

 Product Gene Name   

SIGLEC1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Sialic Acid Binding Ig Like Lectin 1 (MBS2027627)
Antigen: Sialic Acid Binding Ig Like Lectin 1 (SIGLEC1) (MBS2009590)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
 Chromosome Location    Chromosome: 20; NC_000020.10 (3667617..3693213, complement). Location: 20p13
 OMIM    600751
 3D Structure    ModBase 3D Structure for Q9BZZ2
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Pro1272~Leu1411 (Accession # Q9BZZ2) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of SIGLEC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SIGLEC1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for SIGLEC1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of SIGLEC1 recombinant protein    SIGLEC1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SIGLEC1. It may not necessarily be applicable to this product.
 NCBI GI #    13489095
 NCBI GeneID    6614
 NCBI Accession #    NP_075556.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_023068.3 [Other Products]
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 UniProt Primary Accession #    Q9BZZ2 [Other Products]
 UniProt Secondary Accession #    Q96DL4; Q9GZS5; Q9H1H6; Q9H1H7; Q9H7L7 [Other Products]
 UniProt Related Accession #    Q9BZZ2 [Other Products]
 Molecular Weight    16.2kDa
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 NCBI Official Full Name    sialoadhesin
 NCBI Official Synonym Full Names    sialic acid binding Ig-like lectin 1, sialoadhesin
 NCBI Official Symbol    SIGLEC1 [Similar Products]
 NCBI Official Synonym Symbols   
SN; CD169; SIGLEC-1; dJ1009E24.1
[Similar Products]
 NCBI Protein Information    sialoadhesin; sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1
 UniProt Protein Name    Sialoadhesin
 UniProt Synonym Protein Names   
Sialic acid-binding Ig-like lectin 1
 Protein Family    Sialoadhesin
 UniProt Gene Name    SIGLEC1 [Similar Products]
 UniProt Synonym Gene Names    SN; Siglec-1 [Similar Products]
 UniProt Entry Name    SN_HUMAN
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 NCBI Summary for SIGLEC1    This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIGLEC1    SIGLEC1: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to membrane; plasma membrane; extracellular region

Molecular Function: carbohydrate binding

Biological Process: cell-cell adhesion; cell-matrix adhesion; endocytosis; inflammatory response
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 Research Articles on SIGLEC1    1. downregulation of CD169 expression or neutralizing CD169 function abrogated dendritic cell-mediated HIV-1 capture and trans infection, while exogenous expression of CD169 in receptor-naive cells rescued glycosphingolipid-dependent capture and trans infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIGLEC1 recombinant proteinPathways associated with SIGLEC1 recombinant protein
 Reference Product  PubMed Publications
 RSAD2 recombinant protein  >2 publications with SIGLEC1 and RSAD2
 MUC1 recombinant protein  >2 publications with SIGLEC1 and MUC1
 SPN recombinant protein  >1 publications with SIGLEC1 and SPN
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with SIGLEC1 recombinant proteinOrgans/Tissues associated with SIGLEC1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with SIGLEC1 and Neoplasms
 Inflammation Antibodies  >17 publications with SIGLEC1 and Inflammation
 Nervous System Diseases Antibodies  >8 publications with SIGLEC1 and Nervous System Diseases
 Skin Diseases Antibodies  >7 publications with SIGLEC1 and Skin Diseases
 Necrosis Antibodies  >6 publications with SIGLEC1 and Necrosis
 Anemia Antibodies  >5 publications with SIGLEC1 and Anemia
 Bone Marrow Diseases Antibodies  >4 publications with SIGLEC1 and Bone Marrow Diseases
 Atherosclerosis Antibodies  >4 publications with SIGLEC1 and Atherosclerosis
 Lung Diseases Antibodies  >4 publications with SIGLEC1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >3 publications with SIGLEC1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with SIGLEC1 and Blood
 Bone Antibodies  >25 publications with SIGLEC1 and Bone
 Spleen Antibodies  >21 publications with SIGLEC1 and Spleen
 Liver Antibodies  >13 publications with SIGLEC1 and Liver
 Ovary Antibodies  >3 publications with SIGLEC1 and Ovary
 Lung Antibodies  >3 publications with SIGLEC1 and Lung
 Brain Antibodies  >3 publications with SIGLEC1 and Brain
 Kidney Antibodies  >3 publications with SIGLEC1 and Kidney
 Eye Antibodies  >2 publications with SIGLEC1 and Eye
 Uterus Antibodies  >2 publications with SIGLEC1 and Uterus
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