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STAT1 recombinant protein :: Signal Transducer and Activator of Transcription 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142809 STAT1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Signal Transducer and Activator of Transcription 1 (STAT1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Signal Transducer and Activator of Transcription 1

 Product Synonym Names    STAT1 Human; Signal Transducer and Activator of Transcription 1 Human Recombinant; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1; ISGF-3; STAT91; DKFZp686B04100
 Product Gene Name   

STAT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EV
 OMIM    600555
 3D Structure    ModBase 3D Structure for P42224
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    STAT1 0.5mg/ml protein solution contains 20mM Tris-HCl buffer pH-8, 0.1M Nacl, 1mM DTT and 10% glycerol
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 Source    E Coli
 Physical Appearance    Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of STAT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for STAT1 recombinant protein

   Description: STAT1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 732 amino acids (1-712 a.a.) and having a molecular mass of 85.2 kDa. The STAT1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: STAT1 is a member of the Signal Transducers and Activators of Transcriptionfamily of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type Ior type IIinterferons. In response to IFN-?stimulation, STAT1 forms homodimers or heterodimers with STAT3that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-? or IFN-?stimulation, STAT1 forms a heterodimer with STAT2that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).
 Product Categories/Family for STAT1 recombinant protein    PROTEIN KINASES; Enzymes; Protein Kinases
NCBI/Uniprot data below describe general gene information for STAT1. It may not necessarily be applicable to this product.
 NCBI GI #    6274552
 NCBI GeneID    6772
 NCBI Accession #    NP_009330.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007315.3 [Other Products]
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 UniProt Primary Accession #    P42224 [Other Products]
 UniProt Secondary Accession #    Q53S88; Q53XW4; Q68D00; Q9UDL5; A8K989; B2RCA0; D2KFR8; D3DPI7 [Other Products]
 UniProt Related Accession #    P42224 [Other Products]
 Molecular Weight    85.2kDa
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 NCBI Official Full Name    signal transducer and activator of transcription 1-alpha/beta isoform alpha
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 1, 91kDa
 NCBI Official Symbol    STAT1 [Similar Products]
 NCBI Official Synonym Symbols   
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription-1; transcription factor ISGF-3 components p91/p84
 UniProt Protein Name    Signal transducer and activator of transcription 1-alpha/beta
 UniProt Synonym Protein Names   
Transcription factor ISGF-3 components p91/p84
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT1 [Similar Products]
 UniProt Entry Name    STAT1_HUMAN
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 NCBI Summary for STAT1    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAT1    STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: nucleoplasm; axon; cytoplasm; dendrite; nuclear chromatin; nucleolus; cytosol; nucleus

Molecular Function: identical protein binding; signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; double-stranded DNA binding; transcription factor activity; tumor necrosis factor receptor binding; CCR5 chemokine receptor binding

Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; cellular response to insulin stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter

Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
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 Research Articles on STAT1    1. Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STAT1 recombinant proteinPathways associated with STAT1 recombinant protein
 Reference Product  PubMed Publications
 STAT3 recombinant protein  >1776 publications with STAT1 and STAT3
 JAK2 recombinant protein  >637 publications with STAT1 and JAK2
 JAK1 recombinant protein  >613 publications with STAT1 and JAK1
 IRF1 recombinant protein  >310 publications with STAT1 and IRF1
 TYK2 recombinant protein  >245 publications with STAT1 and TYK2
 IRF9 recombinant protein  >168 publications with STAT1 and IRF9
 EGFR recombinant protein  >70 publications with STAT1 and EGFR
 IFNGR1 recombinant protein  >48 publications with STAT1 and IFNGR1
 CREBBP recombinant protein  >24 publications with STAT1 and CREBBP
 EP300 recombinant protein  >9 publications with STAT1 and EP300
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with STAT1 recombinant proteinOrgans/Tissues associated with STAT1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >860 publications with STAT1 and Inflammation
 Necrosis Antibodies  >552 publications with STAT1 and Necrosis
 Disease Models, Animal Antibodies  >338 publications with STAT1 and Disease Models, Animal
 Liver Diseases Antibodies  >276 publications with STAT1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >205 publications with STAT1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >186 publications with STAT1 and Lung Diseases
 Disease Progression Antibodies  >146 publications with STAT1 and Disease Progression
 Neoplasms, Experimental Antibodies  >146 publications with STAT1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >138 publications with STAT1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >118 publications with STAT1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1532 publications with STAT1 and Blood
 Liver Antibodies  >443 publications with STAT1 and Liver
 Lung Antibodies  >338 publications with STAT1 and Lung
 Bone Antibodies  >319 publications with STAT1 and Bone
 Brain Antibodies  >290 publications with STAT1 and Brain
 Vascular Antibodies  >269 publications with STAT1 and Vascular
 Skin Antibodies  >204 publications with STAT1 and Skin
 Kidney Antibodies  >177 publications with STAT1 and Kidney
 Intestine Antibodies  >112 publications with STAT1 and Intestine
 Eye Antibodies  >86 publications with STAT1 and Eye
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