NP_001254651.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,879 Da
NCBI Official Full Name
signal recognition particle subunit SRP72 isoform 2
NCBI Official Synonym Full Names
signal recognition particle 72
NCBI Protein Information
signal recognition particle subunit SRP72
UniProt Protein Name
Signal recognition particle subunit SRP72
UniProt Synonym Protein Names
Signal recognition particle 72 kDa protein
UniProt Synonym Gene Names
NCBI Summary for SRP72
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
UniProt Comments for SRP72
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Research Articles on SRP72
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Products associated with SRP72 recombinant protein
Pathways associated with SRP72 recombinant protein
Diseases associated with SRP72 recombinant protein
Organs/Tissues associated with SRP72 recombinant protein
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