Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Stat3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Elastase Native Protein
 • Aurora kinase A - AURKA Peptide
 • Akt Antibody
 • 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase e... ELISA Kit
 • BAD Antibody
 • Apolipoprotein L1 (APOL1) ELISA Kit
 • Adipocytokine Zinc Alpha 2 Glycoprotein (ZAG) ELISA Kit
 • Borrelia burgdorferi (Bbu297_A40) Antibody
 • Polymeric Immunoglobulin Receptor (PIGR) ELISA Kit
 • Interleukin-36 alpha (IL36A) ELISA Kit
 • Beta-crystallin B1 (CRYBB1) ELISA Kit
 • Schistosoma japonicum SJCHGC06900 Recombinant Protein
 • Actin Alpha 2, Smooth Muscle (ACTa2) ELISA Kit
 • RIPK1 Blocking Peptide
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Stat3 recombinant protein :: Signal transducer and activator of transcription 3 (Stat3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS959931 Stat3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,205 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,225 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,340 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,590 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,625 +2 FREE 8GB USB
0.2 mg (Yeast)  /  $1,660 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,700 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,795 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,880 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,390 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,420 +3 FREE 8GB USB
1 mg (E-Coli)  /  $2,540 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,845 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,170 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Signal transducer and activator of transcription 3 (Stat3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Signal transducer and activator of transcription 3 (Stat3)

 Product Synonym Names    Signal transducer and activator of transcription 3; Acute-phase response factor
 Product Gene Name   

Stat3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Stat3; Aprf [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS959931 COA    COA PDF
 Sequence Positions    1-770aa; Full length protein
 Sequence    MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDMD LTSECATSPM
 3D Structure    ModBase 3D Structure for P42227
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Mus musculus (Mouse)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Stat3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for Stat3 recombinant protein

   This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI/Uniprot data below describe general gene information for Stat3. It may not necessarily be applicable to this product.
 NCBI GI #    22094115
 NCBI GeneID    20848
 NCBI Accession #    NP_035616.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011486.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P42227 [Other Products]
 UniProt Secondary Accession #    A2A5D1; B7ZC17 [Other Products]
 UniProt Related Accession #    P42227 [Other Products]
 Molecular Weight    87,967 Da
Table BarTOPTable Bar
 NCBI Official Full Name    signal transducer and activator of transcription 3 isoform 3
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 3
 NCBI Official Symbol    Stat3 [Similar Products]
 NCBI Official Synonym Symbols   
Aprf; AW109958; 1110034C02Rik
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 3; acute phase response factor; acute-phase response factor
 UniProt Protein Name    Signal transducer and activator of transcription 3
 UniProt Synonym Protein Names   
Acute-phase response factor
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    Stat3 [Similar Products]
 UniProt Synonym Gene Names    Aprf [Similar Products]
 UniProt Entry Name    STAT3_MOUSE
Section Bar
 NCBI Summary for Stat3    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Section Bar
 UniProt Comments for Stat3    STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; DNA-binding; Transcription factor; Nuclear receptor co-regulator

Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; cytoplasm; plasma membrane; intracellular; nucleus

Molecular Function: protein dimerization activity; protein binding; ligand-dependent nuclear receptor activity; signal transducer activity; DNA binding; sequence-specific DNA binding; transcription factor binding; protein phosphatase binding; protein kinase binding; transcription factor activity; CCR5 chemokine receptor binding; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; thermoregulation; glucose homeostasis; signal transduction; response to estradiol stimulus; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; astrocyte differentiation; protein import into nucleus; acute-phase response; negative regulation of glycolysis; positive regulation of Notch signaling pathway; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; eating behavior; cytokine and chemokine mediated signaling pathway; stem cell maintenance; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; cell proliferation; sexual reproduction; response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; regulation of mitochondrial membrane permeability; eye photoreceptor cell differentiation; phosphorylation
Table BarTOPTable Bar
 Research Articles on Stat3    1. Omega-3 fatty acids reduce interleukin 6 induced GP130 dimerization and STAT3 phosphorylation in isolated mouse splenic CD4 T cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with Stat3 recombinant proteinPathways associated with Stat3 recombinant protein
 Reference Product  PubMed Publications
 Src recombinant protein  >628 publications with Stat3 and Src
 Jak1 recombinant protein  >489 publications with Stat3 and Jak1
 Jun recombinant protein  >270 publications with Stat3 and Jun
 Il6st recombinant protein  >257 publications with Stat3 and Il6st
 Map3k1 recombinant protein  >10 publications with Stat3 and Map3k1
 Prkcd recombinant protein  >8 publications with Stat3 and Prkcd
 Pik3r1 recombinant protein  >2 publications with Stat3 and Pik3r1
 Isl1 recombinant protein  >1 publications with Stat3 and Isl1
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with Stat3 recombinant proteinOrgans/Tissues associated with Stat3 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2892 publications with Stat3 and Neoplasms
 Inflammation Antibodies  >1123 publications with Stat3 and Inflammation
 Cardiovascular Diseases Antibodies  >620 publications with Stat3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >609 publications with Stat3 and Disease Models, Animal
 Necrosis Antibodies  >579 publications with Stat3 and Necrosis
 Adenocarcinoma Antibodies  >461 publications with Stat3 and Adenocarcinoma
 Liver Diseases Antibodies  >431 publications with Stat3 and Liver Diseases
 Nervous System Diseases Antibodies  >391 publications with Stat3 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >374 publications with Stat3 and Gastrointestinal Diseases
 Neoplasms, Experimental Antibodies  >329 publications with Stat3 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1921 publications with Stat3 and Blood
 Other Antibodies  >1271 publications with Stat3 and Other
 Liver Antibodies  >935 publications with Stat3 and Liver
 Brain Antibodies  >745 publications with Stat3 and Brain
 Muscle Antibodies  >572 publications with Stat3 and Muscle
 Bone Antibodies  >532 publications with Stat3 and Bone
 Lung Antibodies  >514 publications with Stat3 and Lung
 Heart Antibodies  >407 publications with Stat3 and Heart
 Bone Marrow Antibodies  >368 publications with Stat3 and Bone Marrow
 Skin Antibodies  >339 publications with Stat3 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions