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Stat3 recombinant protein :: Signal transducer and activator of transcription 3 (Stat3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS959931 Stat3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,205 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,340 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,590 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,625 +2 FREE 8GB USB
0.2 mg (Yeast)  /  $1,660 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,700 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,795 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,880 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,390 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,420 +3 FREE 8GB USB
1 mg (E-Coli)  /  $2,540 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,845 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,170 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Signal transducer and activator of transcription 3 (Stat3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Signal transducer and activator of transcription 3 (Stat3)

 Product Gene Name   

Stat3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS959931 COA    COA PDF
 Sequence Positions    1-770aa, Full length protein
 Sequence    MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDMD LTSECATSPM
 3D Structure    ModBase 3D Structure for P42227
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Stat3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Stat3 recombinant protein

   This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI/Uniprot data below describe general gene information for Stat3. It may not necessarily be applicable to this product.
 NCBI GI #    47458804
 NCBI GeneID    20848
 NCBI Accession #    NP_998824.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_213659.3 [Other Products]
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 UniProt Primary Accession #    P42227 [Other Products]
 UniProt Secondary Accession #    A2A5D1; B7ZC17 [Other Products]
 UniProt Related Accession #    P42227 [Other Products]
 Molecular Weight    87,967 Da
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 NCBI Official Full Name    signal transducer and activator of transcription 3 isoform 1
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 3
 NCBI Official Symbol    Stat3 [Similar Products]
 NCBI Official Synonym Symbols   
Aprf; AW109958; 1110034C02Rik
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 3
 UniProt Protein Name    Signal transducer and activator of transcription 3
 UniProt Synonym Protein Names   
Acute-phase response factor
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    Stat3 [Similar Products]
 UniProt Synonym Gene Names    Aprf [Similar Products]
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 NCBI Summary for Stat3    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Stat3    Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (PubMed:12594516). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:16825198). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (PubMed:20215569). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (PubMed:23401489).
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 Research Articles on Stat3    1. alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Stat3 recombinant proteinPathways associated with Stat3 recombinant protein
 Reference Product  PubMed Publications
 Stat1 recombinant protein  >1960 publications with Stat3 and Stat1
 Jak2 recombinant protein  >1866 publications with Stat3 and Jak2
 Src recombinant protein  >958 publications with Stat3 and Src
 Socs3 recombinant protein  >879 publications with Stat3 and Socs3
 Jak1 recombinant protein  >737 publications with Stat3 and Jak1
 Egfr recombinant protein  >599 publications with Stat3 and Egfr
 Tyk2 recombinant protein  >260 publications with Stat3 and Tyk2
 Jak3 recombinant protein  >251 publications with Stat3 and Jak3
 Socs1 recombinant protein  >248 publications with Stat3 and Socs1
 Lck recombinant protein  >29 publications with Stat3 and Lck
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 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
Diseases associated with Stat3 recombinant proteinOrgans/Tissues associated with Stat3 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2597 publications with Stat3 and Inflammation
 Carcinoma Antibodies  >2108 publications with Stat3 and Carcinoma
 Disease Models, Animal Antibodies  >1395 publications with Stat3 and Disease Models, Animal
 Necrosis Antibodies  >1048 publications with Stat3 and Necrosis
 Adenocarcinoma Antibodies  >937 publications with Stat3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >688 publications with Stat3 and Breast Neoplasms
 Liver Neoplasms Antibodies  >578 publications with Stat3 and Liver Neoplasms
 Autoimmune Diseases Antibodies  >560 publications with Stat3 and Autoimmune Diseases
 Cell Transformation, Neoplastic Antibodies  >514 publications with Stat3 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >511 publications with Stat3 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3577 publications with Stat3 and Blood
 Other Antibodies  >2200 publications with Stat3 and Other
 Liver Antibodies  >1736 publications with Stat3 and Liver
 Brain Antibodies  >1406 publications with Stat3 and Brain
 Lung Antibodies  >1213 publications with Stat3 and Lung
 Bone Antibodies  >1010 publications with Stat3 and Bone
 Muscle Antibodies  >999 publications with Stat3 and Muscle
 Heart Antibodies  >745 publications with Stat3 and Heart
 Skin Antibodies  >641 publications with Stat3 and Skin
 Bone Marrow Antibodies  >640 publications with Stat3 and Bone Marrow
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