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SIGIRR recombinant protein :: Single Ig IL1 Related Receptor (SIGIRR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010695 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) SIGIRR recombinant protein
Unit / Price
0.01 mg  /  $185 +1 FREE 8GB USB
0.05 mg  /  $385 +1 FREE 8GB USB
0.1 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Single Ig IL1 Related Receptor (SIGIRR), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Single Ig IL1 Related Receptor (SIGIRR)

 Product Gene Name   

SIGIRR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-MAGVCD RVPN FLSPSEDQAL GPALGSAVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS HFSLHQDFWV SDNFSEIVSS VLVFNLTKAE DYGTFTCSAW NVSSHSFTLW RAGPAGHV
 Chromosome Location    Chromosome: 1; NC_005100.3 (220817750..220826497, complement). Location: 1q41
 3D Structure    ModBase 3D Structure for Q4V892
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Met1~Val118 (Accession # Q4V892) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of SIGIRR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SIGIRR recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for SIGIRR recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for SIGIRR. It may not necessarily be applicable to this product.
 NCBI GI #    67846050
 NCBI GeneID    309106
 NCBI Accession #    NP_001020058.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024887.1 [Other Products]
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 UniProt Primary Accession #    Q4V892 [Other Products]
 UniProt Related Accession #    Q4V892 [Other Products]
 Molecular Weight    14.3kDa
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 NCBI Official Full Name    single Ig IL-1-related receptor
 NCBI Official Synonym Full Names    single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
 NCBI Official Symbol    Sigirr [Similar Products]
 NCBI Official Synonym Symbols   
RGD1306732
[Similar Products]
 NCBI Protein Information    single Ig IL-1-related receptor; TIR8; toll/interleukin-1 receptor 8; single Ig IL-1R-related molecule; single immunoglobulin domain-containing IL1R-related protein
 UniProt Protein Name    Single Ig IL-1-related receptor
 UniProt Synonym Protein Names   
Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8
 Protein Family    Single Ig IL-1-related receptor
 UniProt Gene Name    Sigirr [Similar Products]
 UniProt Synonym Gene Names    TIR8 [Similar Products]
 UniProt Entry Name    SIGIR_RAT
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 UniProt Comments for SIGIRR    Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP

By similarity.

Subunit structure: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3

By similarity.

Subcellular location: Membrane; Single-pass type III membrane protein

Potential.

Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 TIR domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIGIRR recombinant proteinDiseases associated with SIGIRR recombinant protein
 Reference Product  PubMed Publications
 Tlr4 recombinant protein  >23 publications with SIGIRR and Tlr4
 Myd88 recombinant protein  >16 publications with SIGIRR and Myd88
 Tollip recombinant protein  >11 publications with SIGIRR and Tollip
 Tirap recombinant protein  >7 publications with SIGIRR and Tirap
 Irak1 recombinant protein  >2 publications with SIGIRR and Irak1
 Tlr5 recombinant protein  >1 publications with SIGIRR and Tlr5
 Irak3 recombinant protein  >1 publications with SIGIRR and Irak3
 Traf6 recombinant protein  >1 publications with SIGIRR and Traf6
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >42 publications with SIGIRR and Inflammation
 Immune System Diseases Antibodies  >17 publications with SIGIRR and Immune System Diseases
 Necrosis Antibodies  >12 publications with SIGIRR and Necrosis
 Disease Models, Animal Antibodies  >7 publications with SIGIRR and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with SIGIRR and Kidney Diseases
 Nervous System Diseases Antibodies  >4 publications with SIGIRR and Nervous System Diseases
 Fibrosis Antibodies  >3 publications with SIGIRR and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with SIGIRR and Cell Transformation, Neoplastic
 Genomic Instability Antibodies  >1 publications with SIGIRR and Genomic Instability
 Weight Loss Antibodies  >1 publications with SIGIRR and Weight Loss
Organs/Tissues associated with SIGIRR recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with SIGIRR and Liver
 Nerve Antibodies  >1 publications with SIGIRR and Nerve
 Heart Antibodies  >1 publications with SIGIRR and Heart
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