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Slit2 recombinant protein :: Slit Homolog 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031306 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $280 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $530 +1 FREE 8GB USB
0.5 mg  /  $1,020 +1 FREE 8GB USB
1 mg  /  $1,520 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Slit Homolog 2 (Slit2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Slit Homolog 2 (Slit2)

 Product Gene Name   

Slit2 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Slit Homolog 2 (MBS2028504)
Antigen: Slit Homolog 2 (MBS2031306)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    E.coli
 Species Reactivity    Mouse
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 Purity/Purification    > 97%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
 Concentration    Original Concentration: 200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residuess    Cys1408~Cys1519
 Tags    N-terminal His Tag
 Tissue Specificity    Secreted
 Traits    Freeze-dried powder
 Predicted isoelectric point    8.8
 Predicted Molecular Mass    13.9kDa
 Accurate Molecular Mass    16kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of Slit2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for Slit2 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of Slit2 recombinant protein    Slit2 recombinant protein Sequence image
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 SDS-PAGE of Slit2 recombinant protein    Slit2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for Slit2. It may not necessarily be applicable to this product.
 NCBI GI #    410304000
 NCBI GeneID    461137
 NCBI Accession #    Q9R1B9 [Other Products]
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 NCBI Official Full Name    slit homolog 2
 NCBI Official Symbol    SLIT2 [Similar Products]
 NCBI Protein Information    slit homolog 2 protein
 UniProt Protein Name    Slit homolog 2
 UniProt Synonym Protein Names   
Slit homolog 2
 Protein Family    Slit homolog 2 protein
 UniProt Gene Name    SLIT2 [Similar Products]
 UniProt Entry Name    K7CZV3_PANTR
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 UniProt Comments for Slit2    SLIT2: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: cytoplasm; extracellular space; plasma membrane; proteinaceous extracellular matrix

Molecular Function: chemorepellent activity; GTPase inhibitor activity; heparan sulfate proteoglycan binding; heparin binding; laminin-1 binding; protein binding; protein homodimerization activity; proteoglycan binding; receptor binding; Roundabout binding

Biological Process: axon extension involved in axon guidance; axon guidance; axonogenesis; branching morphogenesis of a tube; cell migration during sprouting angiogenesis; cell-cell adhesion; central nervous system projection neuron axonogenesis; chemorepulsion involved in postnatal olfactory bulb interneuron migration; corticospinal neuron axon guidance through the spinal cord; dorsal/ventral axon guidance; in utero embryonic development; induction of negative chemotaxis; metanephros development; motor axon guidance; negative chemotaxis; negative regulation of actin filament polymerization; negative regulation of axon extension; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of inflammatory response; negative regulation of leukocyte chemotaxis; negative regulation of protein amino acid phosphorylation; negative regulation of small GTPase mediated signal transduction; negative regulation of smooth muscle cell migration; negative regulation of vascular permeability; neurite morphogenesis; olfactory bulb development; positive regulation of apoptosis; retinal ganglion cell axon guidance; telencephalon cell migration; ureteric bud development
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Slit2 recombinant protein
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
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