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NIS recombinant protein :: Sodium Iodide Symporter Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031325 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Sodium Iodide Symporter (NIS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Sodium Iodide Symporter (NIS)

 Product Gene Name   

NIS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    274400
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 Host    E. coli
 Species Reactivity    Human
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 Purity/Purification    >92%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
 Concentration    Original Concentration: 200g/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Ser547~Leu643
 Tags    Two N-terminal Tags, His-tag and GST-tag
 Tissue Specificity    Thyroid, Ovary
 Subcellular Location    Membrane; Multi-pass membrane protein
 Traits    Freeze-dried powder
 Predicted isoelectric point    4.9
 Predicted Molecular Mass    40.5kDa
 Accurate Molecular Mass    44kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1. Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of NIS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for NIS recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB.

(May be suitable for use in other assays to be determined by the end user.)

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 SDS-Page of NIS recombinant protein    NIS recombinant protein SDS-Page image
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 Sequence of NIS recombinant protein    NIS recombinant protein Sequence image
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NCBI/Uniprot data below describe general gene information for NIS. It may not necessarily be applicable to this product.
 NCBI GI #    1628579
 NCBI GeneID    6528
 NCBI Accession #    AAB17378.1 [Other Products]
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 UniProt Secondary Accession #    O43702; Q2M335; Q9NYB6 [Other Products]
 UniProt Related Accession #    Q92911 [Other Products]
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 NCBI Official Full Name    sodium iodide symporter
 NCBI Official Synonym Full Names    solute carrier family 5 (sodium/iodide cotransporter), member 5
 NCBI Official Symbol    SLC5A5 [Similar Products]
 NCBI Official Synonym Symbols   
NIS; TDH1
[Similar Products]
 NCBI Protein Information    sodium/iodide cotransporter
 UniProt Protein Name    Sodium/iodide cotransporter
 UniProt Synonym Protein Names   
Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5
 UniProt Gene Name    SLC5A5 [Similar Products]
 UniProt Synonym Gene Names    NIS; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter [Similar Products]
 UniProt Entry Name    SC5A5_HUMAN
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 NCBI Summary for NIS    This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
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 UniProt Comments for NIS    SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: integral to membrane; plasma membrane; nucleus; vesicle

Molecular Function: iodide transmembrane transporter activity; sodium:iodide symporter activity

Biological Process: transport; iodide transport; thyroid hormone generation; ion transport; transmembrane transport

Disease: Thyroid Dyshormonogenesis 1
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 Research Articles on NIS    1. concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NIS recombinant proteinPathways associated with NIS recombinant protein
 Reference Product  PubMed Publications
 TSHR recombinant protein  >5 publications with NIS and TSHR
 TPO recombinant protein  >4 publications with NIS and TPO
 DUOX2 recombinant protein  >3 publications with NIS and DUOX2
 SLC26A4 recombinant protein  >2 publications with NIS and SLC26A4
 DUOXA2 recombinant protein  >2 publications with NIS and DUOXA2
 IYD recombinant protein  >2 publications with NIS and IYD
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Organic Anion Transporters Pathway antibodies  Organic Anion Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram
 Thyroxine Biosynthesis Pathway antibodies  Thyroxine Biosynthesis Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with NIS recombinant proteinOrgans/Tissues associated with NIS recombinant protein
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >7 publications with NIS and Thyroid Diseases
 Thyroid Neoplasms Antibodies  >7 publications with NIS and Thyroid Neoplasms
 Breast Neoplasms Antibodies  >2 publications with NIS and Breast Neoplasms
 Prenatal Injuries Antibodies  >1 publications with NIS and Prenatal Injuries
 Liver Diseases Antibodies  >1 publications with NIS and Liver Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with NIS and Prenatal Exposure Delayed Effects
 Prostatic Neoplasms Antibodies  >1 publications with NIS and Prostatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with NIS and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with NIS and Liver Neoplasms
 Poisoning Antibodies  >1 publications with NIS and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with NIS and Brain
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