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sRANKL recombinant protein :: Soluble RANK Ligand Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143815 sRANKL recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Soluble RANK Ligand (sRANKL), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Soluble RANK Ligand, GST Tag

 Product Synonym Names    sRANKL Human, GST; Soluble RANK Ligand Human Recombinant, GST tag; Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE; TNF-related activation-induced cytokine; OPGL; ODF; Osteoclast differentiation factor; Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa B ligand; RANKL; Osteoprotegerin ligand; CD254 antigen; sRANKL; sOdf; hRANKL2; sRANKL GST
 Product Gene Name   

sRANKL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    259710
 3D Structure    ModBase 3D Structure for O14788
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The soluble RANKL protein solution contains 1mM EDTA and PBS pH-7.4.
Sterile Filtered colorelss clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
 Other Notes    Small volumes of sRANKL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for sRANKL recombinant protein

   Description: RANKL Human Recombinant fused to GST tag produced in E Coli is a single, non-glycosylated polypeptide having a molecular mass of 47 kDa. RANKL is purified by proprietary chromatographic techniques.

Introduction: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. By injecting soluble RANKL, novel osteopenia model mice were established in only 50 hours. Degree of bone loss can be controlled by changing doses of sRANKL. RANKL can be used in establishing osteopenia model for in vivo screening of drugs for osteoporosis, determination of effect and mechanism, evaluation of bone anabolic drugs.
 Product Categories/Family for sRANKL recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; RANK Ligand
NCBI/Uniprot data below describe general gene information for sRANKL. It may not necessarily be applicable to this product.
 NCBI GI #    4507595
 NCBI GeneID    8600
 NCBI Accession #    NP_003692.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003701.3 [Other Products]
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 UniProt Primary Accession #    O14788 [Other Products]
 UniProt Secondary Accession #    O14723; Q96Q17; Q9P2Q3 [Other Products]
 UniProt Related Accession #    O14788 [Other Products]
 Molecular Weight    30,523 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 11
 NCBI Official Symbol    TNFSF11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form
 UniProt Gene Name    TNFSF11 [Similar Products]
 UniProt Synonym Gene Names    OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_HUMAN
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 NCBI Summary for sRANKL    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
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 UniProt Comments for sRANKL    TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: extracellular space; integral to plasma membrane; cytoplasm; extracellular region

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of osteoclast differentiation; cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; osteoclast differentiation; activation of JNK activity; positive regulation of corticotropin-releasing hormone secretion; activation of NF-kappaB transcription factor; positive regulation of homotypic cell-cell adhesion; calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; monocyte chemotaxis; organ morphogenesis; tumor necrosis factor-mediated signaling pathway; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of transcription factor activity; positive regulation of T cell activation; protein homooligomerization; bone resorption

Disease: Osteopetrosis, Autosomal Recessive 2
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 Research Articles on sRANKL    1. Below-knee arterial calcification severity is clearly correlated with peripheral neuropathy severity and with several usual cardiovascular risk factors, but not with serum RANKL level.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with sRANKL recombinant proteinPathways associated with sRANKL recombinant protein
 Reference Product  PubMed Publications
 TNFRSF11B recombinant protein  >2350 publications with sRANKL and TNFRSF11B
 TNFRSF11A recombinant protein  >1540 publications with sRANKL and TNFRSF11A
 NFATC1 recombinant protein  >377 publications with sRANKL and NFATC1
 FOS recombinant protein  >222 publications with sRANKL and FOS
 PTH recombinant protein  >210 publications with sRANKL and PTH
 IL17A recombinant protein  >83 publications with sRANKL and IL17A
 STAT3 recombinant protein  >32 publications with sRANKL and STAT3
 IL6 recombinant protein  >29 publications with sRANKL and IL6
 IL11 recombinant protein  >19 publications with sRANKL and IL11
 IL1B recombinant protein  >2 publications with sRANKL and IL1B
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with sRANKL recombinant proteinOrgans/Tissues associated with sRANKL recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1569 publications with sRANKL and Necrosis
 Osteoporosis Antibodies  >1154 publications with sRANKL and Osteoporosis
 Inflammation Antibodies  >554 publications with sRANKL and Inflammation
 Osteolysis Antibodies  >357 publications with sRANKL and Osteolysis
 Cardiovascular Diseases Antibodies  >322 publications with sRANKL and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >242 publications with sRANKL and Breast Neoplasms
 Alveolar Bone Loss Antibodies  >157 publications with sRANKL and Alveolar Bone Loss
 Pain Antibodies  >132 publications with sRANKL and Pain
 Osteopetrosis Antibodies  >124 publications with sRANKL and Osteopetrosis
 Neoplasm Metastasis Antibodies  >117 publications with sRANKL and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >783 publications with sRANKL and Connective Tissue
 Brain Antibodies  >348 publications with sRANKL and Brain
 Liver Antibodies  >107 publications with sRANKL and Liver
 Lymph Node Antibodies  >91 publications with sRANKL and Lymph Node
 Pancreas Antibodies  >17 publications with sRANKL and Pancreas
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