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SLC4A4 recombinant protein :: Solute Carrier Family 4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143530 SLC4A4 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Solute Carrier Family 4 (SLC4A4), Recombinant Protein

 Also Known As   

Recombinant Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4

 Product Synonym Names    SLC4A4 Human; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 Human Recombinant; KNBC; NBC1; NBC2; Pnbc; HNBC1; hhNMC; SLC4A5; DKFZp781H1314; SLC4A4; Electrogenic sodium bicarbonate cotransporter 1; Sodium bicarbonate cotransporter; Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4; kNBC1; NBC; NBCE1
 Product Gene Name   

SLC4A4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGE EDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVD HQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKL PRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIA GIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ
 OMIM    603345
 3D Structure    ModBase 3D Structure for Q9Y6R1
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The SLC4A4 protein solution contains 20mM Tris-HCl, pH-7.5, 0.5mM DTT, 0.1mM PMSF and 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SLC4A4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SLC4A4 recombinant protein

   Description: SLC4A4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 460 amino acids (1-424 a.a.) and having a molecular mass of 51.5 kDa.SLC4A4 is fused to 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: SLC4A4 takes part in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in SLC4A4 gene are associated with proximal renal tubular acidosis. SLC4A4 is involved in the regulation of intracellular pH in several cell types. SLC4A4 Isoform 2 is particularly expressed in kidney at the level of proximal tubules.Amino acid subsitution in SLC4A4 results in an increase of chloride transport.NBC1 takes part in proximal renal tubular acidosis and ocular abnormalities.
 Product Categories/Family for SLC4A4 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for SLC4A4. It may not necessarily be applicable to this product.
 NCBI GI #    148596928
 NCBI GeneID    8671
 NCBI Accession #    NP_001091954.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098484.2 [Other Products]
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 UniProt Primary Accession #    Q9Y6R1 [Other Products]
 UniProt Secondary Accession #    O15153; Q8NEJ2; Q9H262; Q9NRZ1; Q9UIC0; Q9UIC1; Q9UP50; C4B714 [Other Products]
 UniProt Related Accession #    Q9Y6R1 [Other Products]
 Molecular Weight    123,181 Da
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 NCBI Official Full Name    electrogenic sodium bicarbonate cotransporter 1 isoform 1
 NCBI Official Synonym Full Names    solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 NCBI Official Symbol    SLC4A4 [Similar Products]
 NCBI Official Synonym Symbols   
KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; SLC4A5; NBCe1-A
[Similar Products]
 NCBI Protein Information    electrogenic sodium bicarbonate cotransporter 1; Na(+)/HCO3(-) cotransporter; kNBC1; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
 UniProt Protein Name    Electrogenic sodium bicarbonate cotransporter 1
 UniProt Synonym Protein Names   
Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4; kNBC1
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC4A4 [Similar Products]
 UniProt Synonym Gene Names    NBC; NBC1; NBCE1; Sodium bicarbonate cotransporter [Similar Products]
 UniProt Entry Name    S4A4_HUMAN
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 NCBI Summary for SLC4A4    This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for SLC4A4    SLC4A4: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA); also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: transport; bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport

Disease: Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation
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 Research Articles on SLC4A4    1. The cell membrane gene SLC4A4 and the trafficking regulator gene COPA, which also plays an important role in early endosome maturation, were identified for the cellular entry of poly-arginine peptide.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SLC4A4 recombinant proteinPathways associated with SLC4A4 recombinant protein
 Reference Product  PubMed Publications
 SLC4A7 recombinant protein  >17 publications with SLC4A4 and SLC4A7
 SLC26A6 recombinant protein  >10 publications with SLC4A4 and SLC26A6
 CA2 recombinant protein  >5 publications with SLC4A4 and CA2
 CA4 recombinant protein  >2 publications with SLC4A4 and CA4
 AHCYL1 recombinant protein  >1 publications with SLC4A4 and AHCYL1
 Products by Pathway  Pathway Diagram
 Bicarbonate Transporters Pathway antibodies  Bicarbonate Transporters Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with SLC4A4 recombinant proteinOrgans/Tissues associated with SLC4A4 recombinant protein
 Disease Name  Pubmed Publications
 Acidosis, Renal Tubular Antibodies  >44 publications with SLC4A4 and Acidosis, Renal Tubular
 Kidney Diseases Antibodies  >33 publications with SLC4A4 and Kidney Diseases
 Fibrosis Antibodies  >18 publications with SLC4A4 and Fibrosis
 Glaucoma Antibodies  >13 publications with SLC4A4 and Glaucoma
 Cardiovascular Diseases Antibodies  >8 publications with SLC4A4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with SLC4A4 and Disease Models, Animal
 Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation Antibodies  >5 publications with SLC4A4 and Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation
 Edema Antibodies  >4 publications with SLC4A4 and Edema
 Nervous System Diseases Antibodies  >4 publications with SLC4A4 and Nervous System Diseases
 Heart Diseases Antibodies  >3 publications with SLC4A4 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >87 publications with SLC4A4 and Kidney
 Eye Antibodies  >21 publications with SLC4A4 and Eye
 Brain Antibodies  >21 publications with SLC4A4 and Brain
 Pancreas Antibodies  >18 publications with SLC4A4 and Pancreas
 Intestine Antibodies  >15 publications with SLC4A4 and Intestine
 Heart Antibodies  >12 publications with SLC4A4 and Heart
 Muscle Antibodies  >11 publications with SLC4A4 and Muscle
 Liver Antibodies  >9 publications with SLC4A4 and Liver
 Embryonic Tissue Antibodies  >7 publications with SLC4A4 and Embryonic Tissue
 Vascular Antibodies  >5 publications with SLC4A4 and Vascular
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