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SAT1 recombinant protein :: Spermidine/Spermine N1-Acetyltransferase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143861 SAT1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,940 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), Recombinant Protein

 Also Known As   

Recombinant Human Spermidine/Spermine N1-Acetyltransferase 1

 Product Synonym Names    SAT1 Human; Spermidine/Spermine N1-Acetyltransferase 1 Human Recombinant; Diamine acetyltransferase 1; Spermidine/spermine N(1)-acetyltransferase 1; Putrescine acetyltransferase; Polyamine N-acetyltransferase 1; SSAT-1; SSAT; SAT1; SAT; DC21; KFSD; KFSDX
 Product Gene Name   

SAT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E
 OMIM    308800
 3D Structure    ModBase 3D Structure for P21673
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The SAT1 solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SAT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SAT1 recombinant protein

   Description: SAT1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (1-171 a.a.) and having a molecular mass of 22.1kDa.The SAT1 is purified by proprietary chromatographic techniques.

Introduction: SAT-1 is a member the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. SAT1 catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Therefore, SAT-1's role is essential in polyamine homoeostasis, given that acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Increased SAT1 activity causes variety of other effects which include pancreatic cells death, obstruction of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans (KFSD), and hair loss.Defects in the SAT1 gene are linked to KFSD (keratosis follicularis spinulosa decalvans), which is a rare X-linked disorder affecting the skin and the eye. The KFSD affected men show thickening of the skin of the neck, ears, and extremities, particularly the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Even though the majority of the affected families are compatible with an X-linked inheritance, KFSD are found to be clinically and genetically heterogeneous.
 Product Categories/Family for SAT1 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for SAT1. It may not necessarily be applicable to this product.
 NCBI GI #    4506789
 NCBI GeneID    6303
 NCBI Accession #    NP_002961.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002970.3 [Other Products]
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 UniProt Primary Accession #    P21673 [Other Products]
 UniProt Related Accession #    P21673 [Other Products]
 Molecular Weight    20,024 Da
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 NCBI Official Full Name    diamine acetyltransferase 1
 NCBI Official Synonym Full Names    spermidine/spermine N1-acetyltransferase 1
 NCBI Official Symbol    SAT1 [Similar Products]
 NCBI Official Synonym Symbols   
SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1
[Similar Products]
 NCBI Protein Information    diamine acetyltransferase 1; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N1-acetyltransferase alpha
 UniProt Protein Name    Diamine acetyltransferase 1
 UniProt Synonym Protein Names   
Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1
 Protein Family    Serine acetyltransferase
 UniProt Gene Name    SAT1 [Similar Products]
 UniProt Synonym Gene Names    SAT; SSAT; SSAT-1 [Similar Products]
 UniProt Entry Name    SAT1_HUMAN
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 NCBI Summary for SAT1    The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for SAT1    SAT: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX). A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Belongs to the acetyltransferase family.

Protein type: Acetyltransferase; EC 2.3.1.57; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: Xp22.1

Cellular Component: intracellular; cytosol

Molecular Function: protein binding; diamine N-acetyltransferase activity; spermidine binding

Biological Process: spermidine acetylation; polyamine biosynthetic process; putrescine catabolic process; angiogenesis; polyamine metabolic process; regulation of cell proliferation

Disease: Keratosis Follicularis Spinulosa Decalvans, X-linked
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 Research Articles on SAT1    1. The Catabolic enzyme SSAT expression levels was up-regulated in both cell lines; however, the specific SSAT siRNA treatments prevented the EBR-induced apoptosis only in LNCaP (AR+) cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SAT1 recombinant proteinPathways associated with SAT1 recombinant protein
 Reference Product  PubMed Publications
 ODC1 recombinant protein  >2 publications with SAT1 and ODC1
 KRAS recombinant protein  >1 publications with SAT1 and KRAS
 SLC3A2 recombinant protein  >1 publications with SAT1 and SLC3A2
 MAOA recombinant protein  >1 publications with SAT1 and MAOA
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
 Interconversion Of Polyamines Pathway antibodies  Interconversion Of Polyamines Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
Diseases associated with SAT1 recombinant proteinOrgans/Tissues associated with SAT1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with SAT1 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with SAT1 and Brain Diseases
 Kidney Diseases Antibodies  >5 publications with SAT1 and Kidney Diseases
 Disease Models, Animal Antibodies  >4 publications with SAT1 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with SAT1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >2 publications with SAT1 and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with SAT1 and Inflammation
 Fatty Liver Antibodies  >1 publications with SAT1 and Fatty Liver
 Fetal Growth Retardation Antibodies  >1 publications with SAT1 and Fetal Growth Retardation
 Edema Antibodies  >1 publications with SAT1 and Edema
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >31 publications with SAT1 and Mouth
 Blood Antibodies  >26 publications with SAT1 and Blood
 Brain Antibodies  >21 publications with SAT1 and Brain
 Kidney Antibodies  >14 publications with SAT1 and Kidney
 Intestine Antibodies  >6 publications with SAT1 and Intestine
 Liver Antibodies  >6 publications with SAT1 and Liver
 Vascular Antibodies  >5 publications with SAT1 and Vascular
 Muscle Antibodies  >4 publications with SAT1 and Muscle
 Nerve Antibodies  >2 publications with SAT1 and Nerve
 Bone Antibodies  >2 publications with SAT1 and Bone
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