NP_001128524.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
69,510 Da
NCBI Official Full Name
tyrosine-protein kinase SYK isoform Syk(S)
NCBI Official Synonym Full Names
spleen tyrosine kinase
NCBI Official Synonym Symbols
NCBI Protein Information
tyrosine-protein kinase SYK
UniProt Protein Name
Tyrosine-protein kinase SYK
UniProt Synonym Protein Names
Spleen tyrosine kinase; p72-Syk
UniProt Entry Name
KSYK_HUMAN
UniProt Comments for SYK
Syk: a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Syk family; TK group
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex
Molecular Function: integrin binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: adaptive immune response; B cell receptor signaling pathway; blood vessel morphogenesis; cell proliferation; defense response to bacterium; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; platelet activation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway
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Products associated with SYK recombinant protein
Pathways associated with SYK recombinant protein
Diseases associated with SYK recombinant protein
Organs/Tissues associated with SYK recombinant protein
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