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| Product Name
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Spondin 1 (SPON1), Recombinant Protein ★Popular Item★
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| Also Known As
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Recombinant Spondin 1 (SPON1)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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The sequence of the target protein is listed below.
AETS QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC NEDLEQVEKC MLPECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ FGGAPCPETV QRKKCRIRKC LRNPSIQKLR WREARESRRS EQLKEESEGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT VKKRFKSSQF TSCKDKKEIR A
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| Chromosome Location
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Chromosome: 11; NC_000011.9 (13984184..14289679). Location: 11p15.2
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| OMIM
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604989
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| 3D Structure
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ModBase 3D Structure for Q9HCB6
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| Host
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E Coli
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| Purity/Purification
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> 95%
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| Form/Format
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Supplied as lyophilized form in 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
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| Organism
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Homo sapiens (Human)
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| Expression System
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Prokaryotic expression
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| Residues
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Ala597~Ala801 (Accession # Q9HCB6) with N-terminal His-Tag
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| Subcellular Location
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Secreted, extracellular space, extracellular matrix.
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| Predicted isoelectric point
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8.7
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| Predicted Molecular Mass
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25.1kDa
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| Endotoxin Level
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<1.0EU per 1ug (determined by the LAL method)
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| Reconstitution
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Reconstitute in sterile ddH2O.
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| Preparation and Storage
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Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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| Other Notes
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Small volumes of SPON1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for SPON1 recombinant protein
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SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
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| SDS-PAGE of SPON1 recombinant protein
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TOP
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| NCBI/Uniprot data below describe general gene information for SPON1. It may not necessarily be applicable to this product. |
| NCBI GI #
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110347423
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| NCBI GeneID
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10418
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| NCBI Accession #
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NP_006099.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_006108.3
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[Other Products]
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| UniProt Primary Accession #
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Q9HCB6
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[Other Products]
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| UniProt Secondary Accession #
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O94862; Q8NCD7; Q8WUR5; A8K6W5
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[Other Products]
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| UniProt Related Accession #
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Q9HCB6
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[Other Products]
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TOP
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| NCBI Official Full Name
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spondin-1
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| NCBI Official Synonym Full Names
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spondin 1, extracellular matrix protein
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| NCBI Official Symbol
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SPON1
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[Similar Products]
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| NCBI Official Synonym Symbols
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f-spondin; VSGP/F-spondin
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[Similar Products]
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| NCBI Protein Information
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spondin-1; spondin 1, (f-spondin) extracellular matrix protein; vascular smooth muscle cell growth-promoting factor
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| UniProt Protein Name
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Spondin-1
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| UniProt Synonym Protein Names
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F-spondin; Vascular smooth muscle cell growth-promoting factor
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| Protein Family
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Spondin
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| UniProt Gene Name
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SPON1
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[Similar Products]
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| UniProt Synonym Gene Names
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KIAA0762; VSGP
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[Similar Products]
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| UniProt Entry Name
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SPON1_HUMAN
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| UniProt Comments for SPON1
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SPON1: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS. Major factor for vascular smooth muscle cell.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum lumen
Molecular Function: protein binding
Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; cell adhesion; post-translational protein modification
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TOP
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| Research Articles on SPON1
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1. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with SPON1 recombinant protein | Diseases associated with SPON1 recombinant protein |
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| Organs/Tissues associated with SPON1 recombinant protein |
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TOP
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Recombinant Protein 
