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STC 1 recombinant protein :: Stanniocalcin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142653 STC 1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,125 +1 FREE 8GB USB
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 Product Name   

Stanniocalcin-1 (STC 1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Stanniocalcin-1

 Product Synonym Names    STC 1 Human; Stanniocalcin-1 Human Recombinant; Stanniocalcin-1; STC; STC-1
 Product Gene Name   

STC 1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601185
 3D Structure    ModBase 3D Structure for P52823
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 Host    293 Cell Line (Human Embryonic Kidney)
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized in 0.5 mg/ml in 20mM Tris buffer, 20mM NaCl, pH 7.5.
White lyophilized (freeze-dried) powder.
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 Solubility    Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Lyophilized STC-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Stanniocalcin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of STC 1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for STC 1 recombinant protein

   Description: Stanniocalcin-1 Human Recombinant produced in 293 cell line is a single, glycosylated, polypeptide chain containing 240 amino acids and having a total molecular mass of 25.9 kDa. The Stanniocalcin contains two extra residues which were used as a spacer and 8 residues form the C-Terminal Flag- tag.Stanniocalcin is purified by proprietary chromatographic techniques.The amino acid sequence of the recombinant human Stanniocalcin-1 is 100% homologous to the amino acid sequence AA 18-247 of the human mature Human Stanniocalcin-1.

Introduction: Stanniocalcin 1 (STC1) is the mammalian homologue of STC, which was originally identified as a calcium/phosphate-regulating hormone in bony fishes. In contrast, STC1 may play an autocrine and paracrine role with pleiotropic effects in mammals. It is expressed in a wide variety of tissues, but unexpectedly is not detected in the circulation under normal circumstances, which is possibly caused by its attaching to soluble and tethered forms of a high-affinity binding protein. STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis through effects on osteoblasts, osteoclasts, myoblasts/myocytes, and endothelial cells in mouse model. Differential regulation of myocardial STC1 protein expression was reported in heart failure. In addition, STC1 may regulate calcium currents in cardiomyocytes and may contribute to the alterations in calcium homeostasis of the failing heart. STC1 was found to be a selective modulator of hepatocyte growth factor (HGF)-induced endothelial migration and morphogenesis, an inhibitor of macrophage chemotaxis and chemokinesis, suppressor of progesterone and luteinization inhibitor. Together with STC-2, it may play important roles in the processes of implantation and decidualization in the rat. In terminally differentiated adipocytes, it may function as a "survival factor", which contributes to the maintenance of the integrity of mature adipose tissue. In context with its possible role in gestation, a Big STC, a three highermolecular- mass variant has been described. STC1 was identified as one of hypoxia-responsive genes coupled to hypoxia-driven angiogenesis.Current research indicates that STC-1 might be a useful molecular marker to detect tumor cells in blood and bone marrow from patients with various types of malignancies.
 Product Categories/Family for STC 1 recombinant protein    HORMONES; Hormones; Stanniocalcin
NCBI/Uniprot data below describe general gene information for STC 1. It may not necessarily be applicable to this product.
 NCBI GI #    4507265
 NCBI GeneID    6781
 NCBI Accession #    NP_003146.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003155.2 [Other Products]
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 UniProt Primary Accession #    P52823 [Other Products]
 UniProt Secondary Accession #    Q71UE5; B4DN22 [Other Products]
 UniProt Related Accession #    P52823 [Other Products]
 Molecular Weight    20,487 Da
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 NCBI Official Full Name    stanniocalcin-1
 NCBI Official Synonym Full Names    stanniocalcin 1
 NCBI Official Symbol    STC1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    stanniocalcin-1
 UniProt Protein Name    Stanniocalcin-1
 Protein Family    Stanniocalcin
 UniProt Gene Name    STC1 [Similar Products]
 UniProt Synonym Gene Names    STC; STC-1 [Similar Products]
 UniProt Entry Name    STC1_HUMAN
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 NCBI Summary for STC 1    This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STC 1    STC1: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Belongs to the stanniocalcin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: extracellular space; cytoplasm; apical plasma membrane; nucleus

Molecular Function: hormone activity

Biological Process: cellular calcium ion homeostasis; ossification; negative regulation of calcium ion transport; response to vitamin D; decidualization; endothelial cell morphogenesis; negative regulation of cell migration; embryo implantation
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 Research Articles on STC 1    1. High STC1 expression is associated with glioma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STC 1 recombinant proteinDiseases associated with STC 1 recombinant protein
 Reference Product  PubMed Publications
 VEGFA recombinant protein  >6 publications with STC 1 and VEGFA
 SLC34A1 recombinant protein  >3 publications with STC 1 and SLC34A1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with STC 1 and Inflammation
 Cardiovascular Diseases Antibodies  >9 publications with STC 1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >9 publications with STC 1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with STC 1 and Neoplasm Metastasis
 Lung Diseases Antibodies  >7 publications with STC 1 and Lung Diseases
 Kidney Diseases Antibodies  >7 publications with STC 1 and Kidney Diseases
 Nervous System Diseases Antibodies  >5 publications with STC 1 and Nervous System Diseases
 Ovarian Neoplasms Antibodies  >5 publications with STC 1 and Ovarian Neoplasms
 Necrosis Antibodies  >5 publications with STC 1 and Necrosis
 Heart Diseases Antibodies  >4 publications with STC 1 and Heart Diseases
Organs/Tissues associated with STC 1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >22 publications with STC 1 and Kidney
 Bone Antibodies  >18 publications with STC 1 and Bone
 Heart Antibodies  >15 publications with STC 1 and Heart
 Muscle Antibodies  >15 publications with STC 1 and Muscle
 Vascular Antibodies  >14 publications with STC 1 and Vascular
 Brain Antibodies  >11 publications with STC 1 and Brain
 Ovary Antibodies  >10 publications with STC 1 and Ovary
 Embryonic Tissue Antibodies  >9 publications with STC 1 and Embryonic Tissue
 Thyroid Antibodies  >7 publications with STC 1 and Thyroid
 Connective Tissue Antibodies  >6 publications with STC 1 and Connective Tissue
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