NP_001138926.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,824 Da
NCBI Official Full Name
stathmin isoform b
NCBI Official Synonym Full Names
stathmin 1
NCBI Official Synonym Symbols
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215 [Similar Products]
NCBI Protein Information
stathmin; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; prosolin; stathmin 1/oncoprotein 18; transmembrane protein C1orf215
UniProt Protein Name
Stathmin
UniProt Synonym Protein Names
Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
UniProt Synonym Gene Names
UniProt Entry Name
STMN1_HUMAN
NCBI Summary for STMN1
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
UniProt Comments for STMN1
STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol
Molecular Function: tubulin binding; signal transducer activity
Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; brain development; positive regulation of cell motility; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis
Research Articles on STMN1
Precautions
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Products associated with STMN1 recombinant protein
Pathways associated with STMN1 recombinant protein
Diseases associated with STMN1 recombinant protein
Organs/Tissues associated with STMN1 recombinant protein
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