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STMN1 recombinant protein :: Stathmin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143624 STMN1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stathmin-1 (STMN1), Recombinant Protein

 Also Known As   

Recombinant Human Stathmin-1

 Product Synonym Names    STMN1 Human; Stathmin-1 Human Recombinant; Metablastin; Phosphoprotein p19; Oncoprotein p18; PP17; PP19; PR22; Prosolin; C1orf215; FLJ32206; MGC138869; MGC138870; STMN1; Stathmin; Leukemia-associated phosphoprotein p18; Op18; Protein Pr22; LAP18; Lag; SMN
 Product Gene Name   

STMN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MASSDI QVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
 OMIM    151442
 3D Structure    ModBase 3D Structure for P16949
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The STMN1 protein solution contains 20mM Tris-HCl, pH-8 and 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of STMN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for STMN1 recombinant protein

   Description: Recombinant Human Stathmin-1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (1-149 a.a) and having a molecular mass of 19.4 kDa. STMN1 is fused to 20 amino acid His Tga at N-Terminus and purified by conventional chromatography techniques.

Introduction: STMN1 takes part in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is a ubiquitous cytosolic phosphoprotein which functions as an intracellular relay integrating regulatory signals of the cellular environment. Stathmin functions as an Oncoprotein in regulation of the cell cycle. Stathmin mutation results in uncontrolled cell proliferation. Stathmin expression associates with cervical carcinogenesis and tumor progression, thus Stathmin is an important prognostic marker in cervical carcinoma. STMN1, takes part in the prevenative progression of ER-positive primary in breast cancer. Somatic mutation in STMN1 effects cell homeostasis that leads to tumorigenicity.
 Product Categories/Family for STMN1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Stathmin
NCBI/Uniprot data below describe general gene information for STMN1. It may not necessarily be applicable to this product.
 NCBI GI #    224451142
 NCBI GeneID    3925
 NCBI Accession #    NP_001138926.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145454.2 [Other Products]
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 UniProt Primary Accession #    P16949 [Other Products]
 UniProt Secondary Accession #    A2A2D1; B2R4E7; B7Z8N4; D3DPJ5 [Other Products]
 UniProt Related Accession #    P16949 [Other Products]
 Molecular Weight    19,824 Da
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 NCBI Official Full Name    stathmin isoform b
 NCBI Official Synonym Full Names    stathmin 1
 NCBI Official Symbol    STMN1 [Similar Products]
 NCBI Official Synonym Symbols   
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
[Similar Products]
 NCBI Protein Information    stathmin; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; prosolin; stathmin 1/oncoprotein 18; transmembrane protein C1orf215
 UniProt Protein Name    Stathmin
 UniProt Synonym Protein Names   
Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
 Protein Family    Stathmin
 UniProt Gene Name    STMN1 [Similar Products]
 UniProt Synonym Gene Names    C1orf215; LAP18; OP18; Op18; pp19 [Similar Products]
 UniProt Entry Name    STMN1_HUMAN
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 NCBI Summary for STMN1    This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
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 UniProt Comments for STMN1    STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol

Molecular Function: tubulin binding; signal transducer activity

Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; brain development; positive regulation of cell motility; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis
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 Research Articles on STMN1    1. protein expressions of stathmin and EF1alpha were found in DNs of precancerous lesions, whereas they were absent or present at very low levels in normal liver and liver cirrhosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STMN1 recombinant proteinPathways associated with STMN1 recombinant protein
 Reference Product  PubMed Publications
 TP53 recombinant protein  >5 publications with STMN1 and TP53
 MAPK3 recombinant protein  >3 publications with STMN1 and MAPK3
 ADCYAP1 recombinant protein  >1 publications with STMN1 and ADCYAP1
 CDK1 recombinant protein  >1 publications with STMN1 and CDK1
 AURKB recombinant protein  >1 publications with STMN1 and AURKB
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 RB In Cancer Pathway antibodies  RB In Cancer Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 Signaling Mediated By P38-gamma And P38-delta Pathway antibodies  Signaling Mediated By P38-gamma And P38-delta Pathway Diagram
Diseases associated with STMN1 recombinant proteinOrgans/Tissues associated with STMN1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >69 publications with STMN1 and Carcinoma
 Adenocarcinoma Antibodies  >29 publications with STMN1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >27 publications with STMN1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >16 publications with STMN1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >16 publications with STMN1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >13 publications with STMN1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >13 publications with STMN1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >12 publications with STMN1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >12 publications with STMN1 and Carcinoma, Hepatocellular
 Prostatic Neoplasms Antibodies  >11 publications with STMN1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with STMN1 and Brain
 Blood Antibodies  >42 publications with STMN1 and Blood
 Nerve Antibodies  >36 publications with STMN1 and Nerve
 Lung Antibodies  >26 publications with STMN1 and Lung
 Liver Antibodies  >20 publications with STMN1 and Liver
 Lymph Node Antibodies  >20 publications with STMN1 and Lymph Node
 Lymph Antibodies  >20 publications with STMN1 and Lymph
 Prostate Antibodies  >16 publications with STMN1 and Prostate
 Bone Antibodies  >10 publications with STMN1 and Bone
 Kidney Antibodies  >7 publications with STMN1 and Kidney
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