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Stra6 recombinant protein :: Stimulated by retinoic acid gene 6 protein (Stra6) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1196556 Stra6 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,260 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stimulated by retinoic acid gene 6 protein (Stra6), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Stimulated by retinoic acid gene 6 protein (Stra6)

 Product Synonym Names    Recombinant Stimulated by retinoic acid gene 6 protein (Stra6); Stimulated by retinoic acid gene 6 protein; Retinoic acid-responsive protein
 Product Gene Name   

Stra6 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Stra6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    532-670
 Chromosome Location    Chromosome: 9; NC_000075.6 (58129088..58153997). Location: 9; 9 C
 3D Structure    ModBase 3D Structure for O70491
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Stra6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Stra6. It may not necessarily be applicable to this product.
 NCBI GI #    242332599
 NCBI GeneID    20897
 NCBI Accession #    NP_001155947.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001162475.1 [Other Products]
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 UniProt Primary Accession #    O70491 [Other Products]
 UniProt Secondary Accession #    Q6DIA8 [Other Products]
 UniProt Related Accession #    O70491 [Other Products]
 Molecular Weight    73,775 Da [Similar Products]
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 NCBI Official Full Name    stimulated by retinoic acid gene 6 protein
 NCBI Official Synonym Full Names    stimulated by retinoic acid gene 6
 NCBI Official Symbol    Stra6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    stimulated by retinoic acid gene 6 protein; retinoic acid-responsive protein
 UniProt Protein Name    Stimulated by retinoic acid gene 6 protein
 UniProt Synonym Protein Names   
Retinoic acid-responsive protein
 Protein Family    Stimulated by retinoic acid gene 6 protein
 UniProt Gene Name    Stra6 [Similar Products]
 UniProt Entry Name    STRA6_MOUSE
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 UniProt Comments for Stra6    STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: protein complex; membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; vitamin transporter activity

Biological Process: blood vessel development; developmental growth; adrenal gland development; heart development; neuromuscular process; positive regulation of JAK-STAT cascade; ear development; digestive tract morphogenesis; learning; vocal learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; transport; artery morphogenesis; feeding behavior; kidney development; cognition; embryonic gut development; alveolus development; lung development
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 Research Articles on Stra6    1. TTR blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with Stra6 recombinant proteinOrgans/Tissues associated with Stra6 recombinant protein
 Disease Name  Pubmed Publications
 Eye Abnormalities Antibodies  >12 publications with Stra6 and Eye Abnormalities
 Cardiovascular Abnormalities Antibodies  >5 publications with Stra6 and Cardiovascular Abnormalities
 Neoplasms Antibodies  >4 publications with Stra6 and Neoplasms
 Carcinoma Antibodies  >4 publications with Stra6 and Carcinoma
 Microphthalmos Antibodies  >4 publications with Stra6 and Microphthalmos
 Heart Defects, Congenital Antibodies  >3 publications with Stra6 and Heart Defects, Congenital
 Lung Diseases Antibodies  >3 publications with Stra6 and Lung Diseases
 Prostatic Diseases Antibodies  >1 publications with Stra6 and Prostatic Diseases
 Necrosis Antibodies  >1 publications with Stra6 and Necrosis
 Mammary Neoplasms, Experimental Antibodies  >1 publications with Stra6 and Mammary Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >17 publications with Stra6 and Eye
 Lung Antibodies  >9 publications with Stra6 and Lung
 Brain Antibodies  >9 publications with Stra6 and Brain
 Embryonic Tissue Antibodies  >8 publications with Stra6 and Embryonic Tissue
 Spleen Antibodies  >2 publications with Stra6 and Spleen
 Skin Antibodies  >1 publications with Stra6 and Skin
 Kidney Antibodies  >1 publications with Stra6 and Kidney
 Extraembryonic Tissue Antibodies  >1 publications with Stra6 and Extraembryonic Tissue
 Mammary Gland Antibodies  >1 publications with Stra6 and Mammary Gland
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