Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow STIP1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Allograft Inflammatory Factor 1 (AIF1) Recombinant Protein
 • Ran GTPase-activating protein 1 (Rangap1) Recombinant Protein
 • ACTH (POMC) Antibody
 • H-2Ld (public; H-2.m65) Antibody
 • Receptor-interacting serine-threonine-protein kinase 3 (Ripk... ELISA Kit
 • 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
 • Goat F(ab')2 Anti-Mouse IgM (u chain specific) Secondary Antibody
 • integrin, beta 4 (ITGB4) ELISA Kit
 • CXCR3 Blocking Peptide
 • hantavirus (HV) antibody (IgM) ELISA Kit
 • Helicobacter pylori (H. pylori) Antigen
 • P8 - NUPR1 Peptide
 • 5-lipoxygenase (5-LO-LOX) ELISA Kit
 • Lysosome-associated membrane glycoprotein 2 (LAMP2) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

STIP1 recombinant protein :: Stress-induced-phosphoprotein 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203515
SDS-PAGE
Unit / Price
0.1 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $1,335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stress-induced-phosphoprotein 1 (STIP1), Recombinant Protein

 Also Known As   

Stress-induced-phosphoprotein 1, 1-543aa,Human, His tag, E Coli

 Product Synonym Names    Hsp70/Hsp90-organizing protein; HOP; IEF-SSP-3521; P60; STI1; STI1L; STIP1; Stress-induced-phosphoprotein1 Hsc70/Hsp90 organizing protein; NY REN 11 antigen; Stress induced phosphoprotein 1; Transformation sensitive protein IEF SSP 3521.
 Product Gene Name   

STIP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
Section Bar
Section Bar
 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of STIP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for STIP1 recombinant protein

   Stress-induced-phosphoprotein1 (STI1), also known as HOP, belongs to the large group of co-chaperones. The main function of STI1 is to link Hsp70 and Hsp90 together. But recent investigations indicate that it also modulates the chaperone activities of the linked proteins and possibly interacts with other chaperones and proteins. It forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84, as well as interacting with PACRG. Recombinant human STI1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for STIP1 recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for STIP1 recombinant protein   

SDS-PAGE

Section Bar
 SDS-PAGE of STIP1 recombinant protein    STIP1 recombinant protein SDS-PAGE image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for STIP1. It may not necessarily be applicable to this product.
 NCBI GI #    5803181
 NCBI GeneID    10963
 NCBI Accession #    NP_006810 [Other Products]
 NCBI GenBank Nucleotide #    NM_006819.2 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q3ZCU9; Q5TZU9; B4DM70; F5H0T1; G3XAD8 [Other Products]
 UniProt Related Accession #    P31948 [Other Products]
 Molecular Weight    64.8 kDa (563aa) [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    stress-induced-phosphoprotein 1 isoform b
 NCBI Official Synonym Full Names    stress-induced phosphoprotein 1
 NCBI Official Symbol    STIP1 [Similar Products]
 NCBI Official Synonym Symbols   
HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521
[Similar Products]
 NCBI Protein Information    stress-induced-phosphoprotein 1; Hsp70/Hsp90-organizing protein; NY-REN-11 antigen; epididymis secretory sperm binding protein Li 94n; hsc70/Hsp90-organizing protein; renal carcinoma antigen NY-REN-11; transformation-sensitive protein IEF SSP 3521
 UniProt Protein Name    Stress-induced-phosphoprotein 1
 UniProt Synonym Protein Names   
Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521
 Protein Family    Stress-induced-phosphoprotein
 UniProt Gene Name    STIP1 [Similar Products]
 UniProt Synonym Gene Names    STI1; Hop [Similar Products]
 UniProt Entry Name    STIP1_HUMAN
Section Bar
 NCBI Summary for STIP1    STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Section Bar
 UniProt Comments for STIP1    STI1: a protein that is apparently involved in the response to stress. Specifically interacts with the C-terminal tails of Hsp70 and Hsp90 via TPR1 and TPR2A domains. Deletion of STI1 reduces the activity of the glucocorticoid receptor, a Hsp90 target protein. Phosphorylated in vitro by p90RSK and casein kinase II.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; nucleus

Molecular Function: protein binding

Biological Process: response to stress
Table BarTOPTable Bar
 

Product References and Citations for STIP1 recombinant protein

   Johnson BD., et al. (1998) J Biol Chem. 273(6):3679-86.
Van Der Spuy J., et al. (2001) Biochem J. 21:462-469.
Section Bar
 Research Articles on STIP1    1. Increased STIP1 expression is associated with poor survival outcome in epithelial ovarian cancer (EOC), and STIP1 may represent a useful therapeutic target in EOC patients.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with STIP1 recombinant proteinPathways associated with STIP1 recombinant protein
 Reference Product  PubMed Publications
 DNAJB1 recombinant protein  >6 publications with STIP1 and DNAJB1
 CDC37 recombinant protein  >3 publications with STIP1 and CDC37
 PTGES3 recombinant protein  >2 publications with STIP1 and PTGES3
 PRNP recombinant protein  >2 publications with STIP1 and PRNP
 HSP90AA1 recombinant protein  >2 publications with STIP1 and HSP90AA1
 WDR36 recombinant protein  >1 publications with STIP1 and WDR36
 AHSA1 recombinant protein  >1 publications with STIP1 and AHSA1
 Products by Pathway  Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
Diseases associated with STIP1 recombinant proteinOrgans/Tissues associated with STIP1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with STIP1 and Inflammation
 Nervous System Diseases Antibodies  >8 publications with STIP1 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with STIP1 and Brain Diseases
 Disease Models, Animal Antibodies  >3 publications with STIP1 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with STIP1 and Liver Diseases
 Necrosis Antibodies  >3 publications with STIP1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with STIP1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with STIP1 and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with STIP1 and Breast Neoplasms
 Hypertension Antibodies  >1 publications with STIP1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with STIP1 and Brain
 Blood Antibodies  >16 publications with STIP1 and Blood
 Muscle Antibodies  >8 publications with STIP1 and Muscle
 Bone Antibodies  >6 publications with STIP1 and Bone
 Liver Antibodies  >6 publications with STIP1 and Liver
 Eye Antibodies  >5 publications with STIP1 and Eye
 Lung Antibodies  >5 publications with STIP1 and Lung
 Nerve Antibodies  >5 publications with STIP1 and Nerve
 Heart Antibodies  >4 publications with STIP1 and Heart
 Vascular Antibodies  >4 publications with STIP1 and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions