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CXCL12 recombinant protein :: Stromal cell-derived factor 1 protein (CXCL12) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969192 CXCL12 recombinant protein
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stromal cell-derived factor 1 protein (CXCL12), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active)

 Product Synonym Names    SDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH
 Product Gene Name   

CXCL12 recombinant protein

[Similar Products]
 Product Synonym Gene Name    SDF1; SDF1A; SDF1B [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    22-89aa, Partial
 Sequence    KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
 OMIM    L36033 mRNA
 3D Structure    ModBase 3D Structure for P48061
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20-80 ng/ml.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CXCL12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CXCL12 recombinant protein

   Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. {ECO:0000269|PubMed:11069075, ECO:0000269|PubMed:11859124, ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:8752281}.
 Product Categories/Family for CXCL12 recombinant protein    Biological Active Protein; Immunology; Chemokine
NCBI/Uniprot data below describe general gene information for CXCL12. It may not necessarily be applicable to this product.
 NCBI GI #    10834988
 NCBI GeneID    6387
 NCBI Accession #    NP_000600.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000609.6 [Other Products]
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 UniProt Primary Accession #    P48061 [Other Products]
 UniProt Secondary Accession #    Q2L985; Q2L986; Q2L988; Q5IT36; Q6ICW0; Q9H554; B2R4G0; E7EVL0; H7BYN8 [Other Products]
 UniProt Related Accession #    P48061 [Other Products]
 Molecular Weight    8.0 kDa
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 NCBI Official Full Name    stromal cell-derived factor 1 isoform beta
 NCBI Official Synonym Full Names    C-X-C motif chemokine ligand 12
 NCBI Official Symbol    CXCL12 [Similar Products]
 NCBI Official Synonym Symbols   
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
[Similar Products]
 NCBI Protein Information    stromal cell-derived factor 1
 UniProt Protein Name    Stromal cell-derived factor 1
 UniProt Synonym Protein Names   
C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH
 Protein Family    Stromal cell-derived factor
 UniProt Gene Name    CXCL12 [Similar Products]
 UniProt Synonym Gene Names    SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF [Similar Products]
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 NCBI Summary for CXCL12    This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CXCL12    Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
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 Research Articles on CXCL12    1. High SDF1 expression is associated with Hepatocellular Carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCL12 recombinant proteinPathways associated with CXCL12 recombinant protein
 Reference Product  PubMed Publications
 CXCR4 recombinant protein  >3671 publications with CXCL12 and CXCR4
 CCR7 recombinant protein  >166 publications with CXCL12 and CCR7
 CXCR3 recombinant protein  >133 publications with CXCL12 and CXCR3
 HIF1A recombinant protein  >95 publications with CXCL12 and HIF1A
 CCR4 recombinant protein  >43 publications with CXCL12 and CCR4
 IL8 recombinant protein  >31 publications with CXCL12 and IL8
 JAK2 recombinant protein  >26 publications with CXCL12 and JAK2
 VAV1 recombinant protein  >18 publications with CXCL12 and VAV1
 SDC4 recombinant protein  >6 publications with CXCL12 and SDC4
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with CXCL12 recombinant proteinOrgans/Tissues associated with CXCL12 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >645 publications with CXCL12 and Inflammation
 Cardiovascular Diseases Antibodies  >632 publications with CXCL12 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >448 publications with CXCL12 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >298 publications with CXCL12 and Breast Neoplasms
 Heart Diseases Antibodies  >288 publications with CXCL12 and Heart Diseases
 Neoplasm Invasiveness Antibodies  >271 publications with CXCL12 and Neoplasm Invasiveness
 Ischemia Antibodies  >270 publications with CXCL12 and Ischemia
 HIV Infections Antibodies  >268 publications with CXCL12 and HIV Infections
 Lung Diseases Antibodies  >252 publications with CXCL12 and Lung Diseases
 Necrosis Antibodies  >251 publications with CXCL12 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1672 publications with CXCL12 and Bone
 Bone Marrow Antibodies  >1511 publications with CXCL12 and Bone Marrow
 Vascular Antibodies  >1214 publications with CXCL12 and Vascular
 Brain Antibodies  >558 publications with CXCL12 and Brain
 Muscle Antibodies  >401 publications with CXCL12 and Muscle
 Lung Antibodies  >380 publications with CXCL12 and Lung
 Heart Antibodies  >343 publications with CXCL12 and Heart
 Liver Antibodies  >313 publications with CXCL12 and Liver
 Embryonic Tissue Antibodies  >232 publications with CXCL12 and Embryonic Tissue
 Nerve Antibodies  >184 publications with CXCL12 and Nerve
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