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SuMO-1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203215
SDS-PAGE
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
0.5 mg  /  $650 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SuMO-1, Recombinant Protein

 Also Known As   

SuMO-1, 1-97aa, Human, Recombinant, E Coli

 Product Synonym Names    SMT3 suppressor of mif two 3 homolog 1 isoform a; DAP-1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; uBL1; SMT3 suppressor of mif two 3 homolog 1 isoform a GAP modifying protein 1; GMP 1; PIC 1; Sentrin; Sentrin 1; Small ubiquitin related modifier 1; SMT3 homolog 3; uBL 1; SMT3 suppressor of mif two 3 homolog 1; Sumo1; ubiquitin homology domain protein PIC1; ubiquitin Like 1; ubiquitin like protein SMT3C; ubiquitin like protein uBL1.
 Product Gene Name   

SuMO-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGG
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SuMO-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SuMO-1 recombinant protein

   SuMO-1, also known as small ubiquitin-related modifier 1, is a member of the SuMO protein family and functions in a manner similar to ubiquitin. However, unlike ubiquitin which targets proteins for degradation, SuMO-1 protein participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Recombinant human SuMO1 protein was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for SuMO-1 recombinant protein    ubiquitination
 Applications Tested/Suitable for SuMO-1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of SuMO-1 recombinant protein    SuMO-1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SuMO-1. It may not necessarily be applicable to this product.
 NCBI GI #    4507801
 NCBI GeneID    7341
 NCBI Accession #    NP_003343 [Other Products]
 NCBI GenBank Nucleotide #    NM_003352.4 [Other Products]
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 UniProt Secondary Accession #    P55856; Q6FGG0; Q6NZ62; Q93068; A8MUS8; B2R4I5 [Other Products]
 UniProt Related Accession #    P63165 [Other Products]
 Molecular Weight    11.1 kDa (97aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    small ubiquitin-related modifier 1 isoform a
 NCBI Official Synonym Full Names    small ubiquitin-like modifier 1
 NCBI Official Symbol    SUMO1 [Similar Products]
 NCBI Official Synonym Symbols   
DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
[Similar Products]
 NCBI Protein Information    small ubiquitin-related modifier 1; GAP modifying protein 1; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; sentrin; ubiquitin-homology domain protein PIC1; ubiquitin-like protein SMT3C; ubiquitin-like protein UBL1
 UniProt Protein Name    Small ubiquitin-related modifier 1
 UniProt Synonym Protein Names   
GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1
 UniProt Gene Name    SUMO1 [Similar Products]
 UniProt Synonym Gene Names    SMT3C; SMT3H3; UBL1; SUMO-1; GMP1; Smt3C [Similar Products]
 UniProt Entry Name    SUMO1_HUMAN
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 NCBI Summary for SuMO-1    This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SuMO-1    SUMO1: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Belongs to the ubiquitin family. SUMO subfamily.

Protein type: Ubiquitin-like modifier; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: nucleoplasm; PML body; nuclear membrane; cytoplasm; dendrite; fibrillar center; nucleolus; synapse; nuclear pore; nuclear speck; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; SUMO ligase activity; transcription factor binding

Biological Process: negative regulation of transcription factor activity; cytokine and chemokine mediated signaling pathway; PML body organization and biogenesis; palate development; DNA repair; post-translational protein modification; negative regulation of DNA binding; protein sumoylation; cellular protein metabolic process; regulation of protein localization; positive regulation of protein complex assembly; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of transcription, DNA-dependent

Disease: Orofacial Cleft 10
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Product References and Citations for SuMO-1 recombinant protein

   Evdokimov E., et al. (2008), J Cell Sci, 121:4106-13.
Hecker CM., et al. (2006). J Biol Chem. 281(23):16117-27.
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 Research Articles on SuMO-1    1. These results show that DAP1 is a key regulator, of the induction of apoptosis and reduction of autophagy by subtilase cytotoxin (SubAB).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SuMO-1 recombinant proteinPathways associated with SuMO-1 recombinant protein
 Reference Product  PubMed Publications
 PML recombinant protein  >182 publications with SuMO-1 and PML
 SENP1 recombinant protein  >95 publications with SuMO-1 and SENP1
 RANGAP1 recombinant protein  >69 publications with SuMO-1 and RANGAP1
 SENP2 recombinant protein  >49 publications with SuMO-1 and SENP2
 DAXX recombinant protein  >39 publications with SuMO-1 and DAXX
 UBA2 recombinant protein  >37 publications with SuMO-1 and UBA2
 MDM2 recombinant protein  >31 publications with SuMO-1 and MDM2
 TDG recombinant protein  >10 publications with SuMO-1 and TDG
 UBE2I recombinant protein  >7 publications with SuMO-1 and UBE2I
 TP53 recombinant protein  >6 publications with SuMO-1 and TP53
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with SuMO-1 recombinant proteinOrgans/Tissues associated with SuMO-1 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >77 publications with SuMO-1 and Death
 Nervous System Diseases Antibodies  >63 publications with SuMO-1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >38 publications with SuMO-1 and Cardiovascular Diseases
 Inflammation Antibodies  >27 publications with SuMO-1 and Inflammation
 Necrosis Antibodies  >22 publications with SuMO-1 and Necrosis
 Cleft Palate Antibodies  >18 publications with SuMO-1 and Cleft Palate
 Breast Neoplasms Antibodies  >17 publications with SuMO-1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >16 publications with SuMO-1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >16 publications with SuMO-1 and Disease Models, Animal
 Cleft Lip Antibodies  >16 publications with SuMO-1 and Cleft Lip
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >97 publications with SuMO-1 and Brain
 Blood Antibodies  >70 publications with SuMO-1 and Blood
 Heart Antibodies  >39 publications with SuMO-1 and Heart
 Kidney Antibodies  >38 publications with SuMO-1 and Kidney
 Nerve Antibodies  >37 publications with SuMO-1 and Nerve
 Muscle Antibodies  >37 publications with SuMO-1 and Muscle
 Liver Antibodies  >36 publications with SuMO-1 and Liver
 Lung Antibodies  >20 publications with SuMO-1 and Lung
 Vascular Antibodies  >19 publications with SuMO-1 and Vascular
 Testis Antibodies  >19 publications with SuMO-1 and Testis
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