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SuMO-1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203215
SDS-Page
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
0.5 mg  /  $650 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SuMO-1, Recombinant Protein

 Also Known As   

SuMO-1, 1-97aa, Human, E Coli

 Product Synonym Names    SMT3 suppressor of mif two 3 homolog 1 isoform a; SMT3 suppressor of mif two 3 homolog 1 isoform a; DAP-1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; uBL1; SMT3 suppressor of mif two 3 homolog 1 isoform a GAP modifying protein 1; GMP 1; PIC 1; Sentrin; Sentrin 1; Small ubiquitin related modifier 1; SMT3 homolog 3; uBL 1; SMT3 suppressor of mif two 3 homolog 1; Sumo1; ubiquitin homology domain protein PIC1; ubiquitin Like 1; ubiquitin like protein SMT3C; ubiquitin like protein uBL1.
 Product Gene Name   

SuMO-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGG
 OMIM    X99586 mRNA
 3D Structure    ModBase 3D Structure for P63165
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SuMO-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SuMO-1 recombinant protein

   SuMO-1, also known as small ubiquitin-related modifier 1, is a member of the SuMO protein family and functions in a manner similar to ubiquitin. However, unlike ubiquitin which targets proteins for degradation, SuMO-1 protein participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Recombinant human SuMO1 protein was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for SuMO-1 recombinant protein    ubiquitination
 Applications Tested/Suitable for SuMO-1 recombinant protein   

SDS-PAGE

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 SDS-Page of SuMO-1 recombinant protein    SuMO-1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SuMO-1. It may not necessarily be applicable to this product.
 NCBI GI #    4507801
 NCBI GeneID    7341
 NCBI Accession #    NP_003343 [Other Products]
 NCBI GenBank Nucleotide #    NM_003352.4 [Other Products]
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 UniProt Primary Accession #    P63165 [Other Products]
 UniProt Secondary Accession #    P55856; Q6FGG0; Q6NZ62; Q93068; A8MUS8; B2R4I5 [Other Products]
 UniProt Related Accession #    P63165 [Other Products]
 Molecular Weight    11.1 kDa (97aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    small ubiquitin-related modifier 1 isoform a
 NCBI Official Synonym Full Names    small ubiquitin-like modifier 1
 NCBI Official Symbol    SUMO1 [Similar Products]
 NCBI Official Synonym Symbols   
DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
[Similar Products]
 NCBI Protein Information    small ubiquitin-related modifier 1
 UniProt Protein Name    Small ubiquitin-related modifier 1
 UniProt Synonym Protein Names   
GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1
 UniProt Gene Name    SUMO1 [Similar Products]
 UniProt Synonym Gene Names    SMT3C; SMT3H3; UBL1; SUMO-1; GMP1; Smt3C [Similar Products]
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 NCBI Summary for SuMO-1    This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SuMO-1    Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
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Product References and Citations for SuMO-1 recombinant protein

   Evdokimov E., et al. (2008), J Cell Sci, 121:4106-13.; Hecker CM., et al. (2006). J Biol Chem. 281 (23):16117-27.;
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 Research Articles on SuMO-1    1. These results suggest that SUMO1 contributes to hepatocellular carcinoma progression by promoting p65 nuclear translocation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SuMO-1 recombinant proteinPathways associated with SuMO-1 recombinant protein
 Reference Product  PubMed Publications
 SENP1 recombinant protein  >124 publications with SuMO-1 and SENP1
 PIAS1 recombinant protein  >100 publications with SuMO-1 and PIAS1
 RANGAP1 recombinant protein  >77 publications with SuMO-1 and RANGAP1
 RANBP2 recombinant protein  >57 publications with SuMO-1 and RANBP2
 UBA2 recombinant protein  >44 publications with SuMO-1 and UBA2
 PIAS4 recombinant protein  >35 publications with SuMO-1 and PIAS4
 PIAS3 recombinant protein  >33 publications with SuMO-1 and PIAS3
 SAE1 recombinant protein  >32 publications with SuMO-1 and SAE1
 PIAS2 recombinant protein  >32 publications with SuMO-1 and PIAS2
 UBE2I recombinant protein  >9 publications with SuMO-1 and UBE2I
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Fluid Shear Stress And Atherosclerosis Pathway antibodies  Fluid Shear Stress And Atherosclerosis Pathway Diagram
 Fluid Shear Stress And Atherosclerosis Pathway antibodies  Fluid Shear Stress And Atherosclerosis Pathway Diagram
Diseases associated with SuMO-1 recombinant proteinOrgans/Tissues associated with SuMO-1 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >53 publications with SuMO-1 and Cardiovascular Diseases
 Inflammation Antibodies  >38 publications with SuMO-1 and Inflammation
 Disease Models, Animal Antibodies  >30 publications with SuMO-1 and Disease Models, Animal
 Necrosis Antibodies  >29 publications with SuMO-1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >28 publications with SuMO-1 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >23 publications with SuMO-1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >22 publications with SuMO-1 and Breast Neoplasms
 Cleft Palate Antibodies  >21 publications with SuMO-1 and Cleft Palate
 Heart Diseases Antibodies  >20 publications with SuMO-1 and Heart Diseases
 Cleft Lip Antibodies  >20 publications with SuMO-1 and Cleft Lip
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >123 publications with SuMO-1 and Brain
 Blood Antibodies  >86 publications with SuMO-1 and Blood
 Heart Antibodies  >52 publications with SuMO-1 and Heart
 Muscle Antibodies  >50 publications with SuMO-1 and Muscle
 Nerve Antibodies  >47 publications with SuMO-1 and Nerve
 Liver Antibodies  >47 publications with SuMO-1 and Liver
 Kidney Antibodies  >43 publications with SuMO-1 and Kidney
 Lung Antibodies  >26 publications with SuMO-1 and Lung
 Vascular Antibodies  >22 publications with SuMO-1 and Vascular
 Prostate Antibodies  >21 publications with SuMO-1 and Prostate
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