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SDHA recombinant protein :: Succinate dehydrogenase [ubiquinone] flavoprotein subunit Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717214 (PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed)
SDS-PAGE
Unit / Price
0.05 mg  /  $650 +1 FREE 8GB USB
0.2 mg  /  $875 +1 FREE 8GB USB
0.5 mg  /  $965 +1 FREE 8GB USB
1 mg  /  $1,360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Succinate dehydrogenase [ubiquinone] flavoprotein subunit (SDHA), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

 Product Synonym Names    Flavoprotein subunit of complex II; Fp
 Product Gene Name   

SDHA recombinant protein

[Similar Products]
 Product Synonym Gene Name    SDH2; SDHF [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS717214 COA    COA PDF
 Sequence Positions    44-293aa; Partial
 Sequence    SAKVSDSISA QYPVVDHEFD AVVVGAGGAG LRAAFGLSEA GFNTACVTKL FPTRSHTVAA QGGINAALGN MEEDNWRWHF YDTVKGSDWL GDQDAIHYMT EQAPAAVVEL ENYGMPFSRT EDGKIYQRAF GGQSLKFGKG GQAHRCCCVA DRTGHSLLHT LYGRSLRYDT SYFVEYFALD LLMENGECRG VIALCIEDGS IHRIRAKNTV VATGGYGRTY FSCTSAHTST GDGTAMITRA GLPCQDLEFV
 OMIM    252011
 3D Structure    ModBase 3D Structure for P31040
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SDHA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SDHA recombinant protein

   Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.
 Product Categories/Family for SDHA recombinant protein    Transport
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 SDS-PAGE of SDHA recombinant protein    SDHA recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SDHA. It may not necessarily be applicable to this product.
 NCBI GI #    661567360
 NCBI GeneID    6389
 NCBI Accession #    NP_001281261.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001294332.1 [Other Products]
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 UniProt Primary Accession #    P31040 [Other Products]
 UniProt Secondary Accession #    Q16395; Q59GW8; Q8IW48; Q9UMY5; A8K5J6; B4DJ60; E9PBJ5 [Other Products]
 UniProt Related Accession #    P31040 [Other Products]
 Molecular Weight    54.4kD
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 NCBI Official Full Name    succinate dehydrogenase
 NCBI Official Synonym Full Names    succinate dehydrogenase complex flavoprotein subunit A
 NCBI Official Symbol    SDHA [Similar Products]
 NCBI Official Synonym Symbols   
FP; PGL5; SDH1; SDH2; SDHF; CMD1GG
[Similar Products]
 NCBI Protein Information    succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
 UniProt Protein Name    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
 UniProt Synonym Protein Names   
Flavoprotein subunit of complex II; Fp
 Protein Family    Succinate dehydrogenase
 UniProt Gene Name    SDHA [Similar Products]
 UniProt Synonym Gene Names    SDH2; SDHF; Fp [Similar Products]
 UniProt Entry Name    SDHA_HUMAN
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 NCBI Summary for SDHA    This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
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 UniProt Comments for SDHA    SDHA: is the catalytic subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. Complex II contains four subunits: the flavoprotein catalytic subunit SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interaction with SDH5 is required for FAD attachment. Responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHA cause defective mitochondrial oxidative phosphorylation, giving rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. Acetylation of SDHA may control entry of the substrate into the active site, thus regulating its enzymatic activity. Acetylated SDHA may be a SIRT3 substrate SIRT3 is a mitochondrial NAD(+)-dependent deacetylase. Increased succinate levels as a consequence of SDH deficiency inhibit hypoxia inducible factor-1alpha (HIF-1alpha) prolyl hydroxylases leading to sustained HIF-1alpha expression in tumours. Defects in SDHA cause of Leigh syndrome, a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.

Protein type: Oxidoreductase; Mitochondrial; Tumor suppressor; EC 1.3.5.1; Carbohydrate Metabolism - citrate (TCA) cycle; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex II; mitochondrion; myelin sheath

Molecular Function: FAD binding; protein binding; succinate dehydrogenase (ubiquinone) activity; succinate dehydrogenase activity

Biological Process: cellular metabolic process; nervous system development; succinate metabolic process; tricarboxylic acid cycle

Disease: Cardiomyopathy, Dilated, 1gg; Leigh Syndrome; Mitochondrial Complex Ii Deficiency; Paragangliomas 5
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Product References and Citations for SDHA recombinant protein

   Human complex II (succinate-ubiquinone oxidoreductase) cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria.Hirawake H., Wang H., Kuramochi T., Kojima S., Kita K.J. Biochem. 116:221-227(1994) The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.Morris A.A.M., Farnsworth L., Ackrell B.A.C., Turnbull D.M., Birch-MacHin M.A.Biochim. Biophys. Acta 1185:125-128(1994) Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome.Parfait B., Chretien D., Roetig A., Marsac C., Munnich A., Rustin P.Hum. Genet. 106:236-243(2000) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Homo sapiens protein coding cDNA.Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. The DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004)
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 Research Articles on SDHA    1. our findings provide further evidence that patients with KIT/PDGFRA wild-type SDH-deficient GIST harboring SDHA mutations experience good survival outcomes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SDHA recombinant proteinPathways associated with SDHA recombinant protein
 Reference Product  PubMed Publications
 SDHB recombinant protein  >168 publications with SDHA and SDHB
 SDHC recombinant protein  >124 publications with SDHA and SDHC
 SDHAF2 recombinant protein  >53 publications with SDHA and SDHAF2
 CYC1 recombinant protein  >3 publications with SDHA and CYC1
 SUCLG2 recombinant protein  >2 publications with SDHA and SUCLG2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
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 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
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 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
Diseases associated with SDHA recombinant proteinOrgans/Tissues associated with SDHA recombinant protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >25 publications with SDHA and Brain Diseases
 Death Antibodies  >17 publications with SDHA and Death
 Disease Models, Animal Antibodies  >13 publications with SDHA and Disease Models, Animal
 Kidney Diseases Antibodies  >12 publications with SDHA and Kidney Diseases
 Inflammation Antibodies  >12 publications with SDHA and Inflammation
 Neoplasms, Experimental Antibodies  >11 publications with SDHA and Neoplasms, Experimental
 Heart Diseases Antibodies  >11 publications with SDHA and Heart Diseases
 Liver Diseases Antibodies  >9 publications with SDHA and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with SDHA and Liver Neoplasms
 Necrosis Antibodies  >7 publications with SDHA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >42 publications with SDHA and Blood
 Muscle Antibodies  >39 publications with SDHA and Muscle
 Adrenal Gland Antibodies  >38 publications with SDHA and Adrenal Gland
 Brain Antibodies  >35 publications with SDHA and Brain
 Liver Antibodies  >28 publications with SDHA and Liver
 Heart Antibodies  >21 publications with SDHA and Heart
 Kidney Antibodies  >18 publications with SDHA and Kidney
 Lung Antibodies  >17 publications with SDHA and Lung
 Thyroid Antibodies  >12 publications with SDHA and Thyroid
 Bone Antibodies  >11 publications with SDHA and Bone
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