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VAMP2 recombinant protein :: Synaptobrevin 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203017
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synaptobrevin 2 (VAMP2), Recombinant Protein

★Popular Item★
 Also Known As   

Synaptobrevin 2,1-89aa, Human, Recombinant, His- tag, E Coli

 Product Synonym Names    VAMP2; SYB2; Synaptobrevin 2; VAMP-2; Synaptobrevin-2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 FLJ11460; RATVAMPB; RATVAMPIR; SYB; VAMP 2; Vesicle associated membrane protein 2; Vesicle-associated membrane protein 2 (synaptobrevin 2).
 Product Gene Name   

VAMP2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA TAATAPPAAP AGEGGPPAPP PNLTSNRRLQ QTQAQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG ASQFETSAAK LKRKYW
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In Phosphate-buffered saline (pH 7.4), 1mM EDTA
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of VAMP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for VAMP2 recombinant protein

   Synaptobrevin 2(Vehicle-associated membrane, VAMP2), which is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a C-terminal. Synaptobrevin 2 is predominantly expressed in Langerhans islets and glomerular cells. The N-terminal domain of the protein (residues 1-89) forms a specific SNARE complex with the target membrane-associated t- or Q-SNAREs syntaxin 1 and SNAP-25.
 Product Categories/Family for VAMP2 recombinant protein    Neuroscience
 Applications Tested/Suitable for VAMP2 recombinant protein   

SDS-PAGE

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 SDS-PAGE of VAMP2 recombinant protein    VAMP2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for VAMP2. It may not necessarily be applicable to this product.
 NCBI GI #    172072620
 NCBI GeneID    6844
 NCBI Accession #    NP_055047 [Other Products]
 NCBI GenBank Nucleotide #    NM_014232.2 [Other Products]
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 UniProt Secondary Accession #    P19065; Q9BUC2 [Other Products]
 UniProt Related Accession #    P63027 [Other Products]
 Molecular Weight    13.8 kDa (126 aa) [Similar Products]
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 NCBI Official Full Name    vesicle-associated membrane protein 2
 NCBI Official Synonym Full Names    vesicle-associated membrane protein 2 (synaptobrevin 2)
 NCBI Official Symbol    VAMP2 [Similar Products]
 NCBI Official Synonym Symbols   
SYB2; VAMP-2
[Similar Products]
 NCBI Protein Information    vesicle-associated membrane protein 2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2
 UniProt Protein Name    Vesicle-associated membrane protein 2
 UniProt Synonym Protein Names   
Synaptobrevin-2
 Protein Family    Vesicle-associated membrane protein
 UniProt Gene Name    VAMP2 [Similar Products]
 UniProt Synonym Gene Names    SYB2; VAMP-2 [Similar Products]
 UniProt Entry Name    VAMP2_HUMAN
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 NCBI Summary for VAMP2    The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VAMP2    VAMP2: a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: zymogen granule membrane; neuron projection; intracellular membrane-bound organelle; clathrin-coated vesicle; synaptic vesicle membrane; integral to plasma membrane; secretory granule membrane; trans-Golgi network; cytosol; secretory granule; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; cell junction

Molecular Function: calmodulin binding; SNAP receptor activity; protein binding; SNARE binding; protein self-association; syntaxin binding; syntaxin-1 binding; phospholipid binding; calcium-dependent protein binding

Biological Process: exocytosis; natural killer cell degranulation; neurotransmitter secretion; neutrophil degranulation; pathogenesis; calcium ion-dependent exocytosis; regulation of exocytosis; vesicle-mediated transport; vesicle fusion; synaptic transmission; synaptic vesicle exocytosis; protein transport; cellular protein metabolic process; glutamate secretion; cellular response to insulin stimulus; Golgi to plasma membrane protein transport; response to glucose stimulus; energy reserve metabolic process; eosinophil degranulation; protein complex assembly; post-Golgi vesicle-mediated transport; regulation of insulin secretion
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Product References and Citations for VAMP2 recombinant protein

   Lin RC. and Scheller RH. (1997) Neuron. 19:1087-1094.
Hanson PI. et al (1997) Cell 90:523-535.
Scales SJ., et al. (2002) J Biol Chem. 277(31):28271-9.
Windoffer R et al. (1999) Cell Tissue Res 296:499-510
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 Research Articles on VAMP2    1. The genetic variations of VAMP2, Synaptotagmin XI might be indication of the relationship between these genes and idiopathic generalized epilepsy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VAMP2 recombinant proteinPathways associated with VAMP2 recombinant protein
 Reference Product  PubMed Publications
 SNAP25 recombinant protein  >87 publications with VAMP2 and SNAP25
 SNAP23 recombinant protein  >41 publications with VAMP2 and SNAP23
 STX1A recombinant protein  >32 publications with VAMP2 and STX1A
 SYT1 recombinant protein  >14 publications with VAMP2 and SYT1
 SYP recombinant protein  >6 publications with VAMP2 and SYP
 STXBP3 recombinant protein  >5 publications with VAMP2 and STXBP3
 CPLX1 recombinant protein  >2 publications with VAMP2 and CPLX1
 STX4 recombinant protein  >2 publications with VAMP2 and STX4
 STX3 recombinant protein  >1 publications with VAMP2 and STX3
 UNC13B recombinant protein  >1 publications with VAMP2 and UNC13B
 Products by Pathway  Pathway Diagram
 Acetylcholine Neurotransmitter Release Cycle Pathway antibodies  Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
Diseases associated with VAMP2 recombinant proteinOrgans/Tissues associated with VAMP2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >43 publications with VAMP2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >21 publications with VAMP2 and Disease Models, Animal
 Inflammation Antibodies  >11 publications with VAMP2 and Inflammation
 Seizures Antibodies  >7 publications with VAMP2 and Seizures
 Cognition Disorders Antibodies  >6 publications with VAMP2 and Cognition Disorders
 Movement Disorders Antibodies  >6 publications with VAMP2 and Movement Disorders
 Kidney Diseases Antibodies  >5 publications with VAMP2 and Kidney Diseases
 Hypertension Antibodies  >4 publications with VAMP2 and Hypertension
 Memory Disorders Antibodies  >4 publications with VAMP2 and Memory Disorders
 Neurobehavioral Manifestations Antibodies  >4 publications with VAMP2 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >205 publications with VAMP2 and Brain
 Nerve Antibodies  >166 publications with VAMP2 and Nerve
 Muscle Antibodies  >72 publications with VAMP2 and Muscle
 Pancreas Antibodies  >38 publications with VAMP2 and Pancreas
 Blood Antibodies  >36 publications with VAMP2 and Blood
 Kidney Antibodies  >29 publications with VAMP2 and Kidney
 Eye Antibodies  >19 publications with VAMP2 and Eye
 Embryonic Tissue Antibodies  >14 publications with VAMP2 and Embryonic Tissue
 Salivary Gland Antibodies  >12 publications with VAMP2 and Salivary Gland
 Heart Antibodies  >10 publications with VAMP2 and Heart
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