NP_001124397.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
syncytin-1
NCBI Official Synonym Full Names
endogenous retrovirus group W member 1
NCBI Official Synonym Symbols
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV [Similar Products]
NCBI Protein Information
syncytin-1
UniProt Protein Name
Syncytin-1
UniProt Synonym Protein Names
Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin
UniProt Synonym Gene Names
UniProt Entry Name
SYCY1_HUMAN
NCBI Summary for ERVW-1
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for ERVW-1
ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: integral to membrane; plasma membrane; viral envelope
Biological Process: anatomical structure morphogenesis; syncytium formation
Product References and Citations for ERVW-1 recombinant protein
"Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family."
Blond J.-L., Beseme F., Duret L., Bouton O., Bedin F., Perron H., Mandrand B., Mallet F.
J. Virol. 73:1175-1185(1999)
Research Articles on ERVW-1
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Products associated with ERVW-1 recombinant protein
Diseases associated with ERVW-1 recombinant protein
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