View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List SDC1 recombinant protein :: Syndecan-1 / SDC1 / CD138 Recombinant Protein Catalog # MBS2547331 Unit / Price 0.1 mg / $695 +1 FREE 8GB USB 5x0.1 mg / $3,125 +3 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Syndecan-1 / SDC1 / CD138, Recombinant Protein Full Product Name Recombinant Rat Syndecan-1 / SDC1 / CD138 Protein (Fc tag) Product Synonym Names SDC1, Synd1 Product Gene Name SDC1 recombinant protein[Similar Products] Product Synonym Gene Name CD138[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for P26260 Host Human Cells Purity/Purification > 90 % as determined by SDS-PAGE Form/Format Lyophilized from sterile PBS, pH 7.4 Predicted N Terminal Gln 23 Endotoxin < 1.0 EU per mug of the protein as determined by the LAL method Preparation and Storage Samples are stable for up to twelve months from date of receipt at -70 degree C ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of SDC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for SDC1 recombinant protein Background: Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.Description: A DNA sequence encoding the rat SDC1 (P26260) (Met1-Lys253) was expressed, fused with the Fc region of human IgG1 at the C-terminus. Application Notes for SDC1 recombinant protein The recombinant rat SDC1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 472 amino acids and has a predicted molecular mass of 51.2 kDa. The apparent molecular mass of the protein is approximately 92 kDa in SDS-PAGE under reducing conditions. SDS-PAGE of SDC1 recombinant protein TOP NCBI/Uniprot data below describe general gene information for SDC1. It may not necessarily be applicable to this product. NCBI GI # 6981518 NCBI GeneID 25216 NCBI Accession # NP_037158.1 [Other Products] NCBI GenBank Nucleotide # NM_013026.2 [Other Products] UniProt Primary Accession # P26260 [Other Products] UniProt Related Accession # P26260[Other Products] Molecular Weight 33,214 Da TOP NCBI Official Full Name syndecan-1 NCBI Official Synonym Full Names syndecan 1 NCBI Official Symbol Sdc1 [Similar Products] NCBI Official Synonym Symbols HSPG; Synd1; SYNDECA; Syndecan [Similar Products] NCBI Protein Information syndecan-1 UniProt Protein Name Syndecan-1 UniProt Synonym Protein Names CD_antigen: CD138 Protein Family Syndecan UniProt Gene Name Sdc1 [Similar Products] UniProt Synonym Gene Names Synd1; SYND1 [Similar Products] TOP NCBI Summary for SDC1 mouse homolog promotes cell-cell adhesion [RGD, Feb 2006] TOP UniProt Comments for SDC1 syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 6q14Cellular Component: cell surface; cytoplasm; external side of plasma membrane; focal adhesion; protein complexMolecular Function: extracellular matrix binding; glycoprotein binding; protein binding; protein C-terminus bindingBiological Process: cell migration; inflammatory response; myoblast development; odontogenesis; response to calcium ion; response to cAMP; response to glucocorticoid stimulus; response to hydrogen peroxide; response to organic substance; response to toxin; Sertoli cell development; striated muscle cell development; ureteric bud development; Wnt receptor signaling pathway through beta-catenin; wound healing Research Articles on SDC1 1. expression upregulated two months after renal transplantation TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with SDC1 recombinant protein Reference Product PubMed Publications Sdc4 recombinant protein >64 publications with SDC1 and Sdc4 Fgf2 recombinant protein >54 publications with SDC1 and Fgf2 Sdc2 recombinant protein >34 publications with SDC1 and Sdc2 Sdc3 recombinant protein >17 publications with SDC1 and Sdc3 Gpc1 recombinant protein >3 publications with SDC1 and Gpc1 Hpse recombinant protein >3 publications with SDC1 and Hpse Gpc2 recombinant protein >2 publications with SDC1 and Gpc2 Gpc4 recombinant protein >1 publications with SDC1 and Gpc4 Pathways associated with SDC1 recombinant protein Products by Pathway Pathway Diagram A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram Cell Adhesion Molecules (CAMs) Pathway antibodies Cell Adhesion Molecules (CAMs) Pathway Diagram Cell Adhesion Molecules (CAMs) Pathway antibodies Cell Adhesion Molecules (CAMs) Pathway Diagram Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram Chylomicron-mediated Lipid Transport Pathway antibodies Chylomicron-mediated Lipid Transport Pathway Diagram ECM-receptor Interaction Pathway antibodies ECM-receptor Interaction Pathway Diagram ECM-receptor Interaction Pathway antibodies ECM-receptor Interaction Pathway Diagram Extracellular Matrix Organization Pathway antibodies Extracellular Matrix Organization Pathway Diagram Glycosaminoglycan Metabolism Pathway antibodies Glycosaminoglycan Metabolism Pathway Diagram HS-GAG Biosynthesis Pathway antibodies HS-GAG Biosynthesis Pathway Diagram Diseases associated with SDC1 recombinant protein Disease Name Pubmed Publications Cardiovascular Diseases Antibodies >198 publications with SDC1 and Cardiovascular Diseases Inflammation Antibodies >70 publications with SDC1 and Inflammation Breast Neoplasms Antibodies >40 publications with SDC1 and Breast Neoplasms Neoplasm Metastasis Antibodies >37 publications with SDC1 and Neoplasm Metastasis Necrosis Antibodies >36 publications with SDC1 and Necrosis Nervous System Diseases Antibodies >27 publications with SDC1 and Nervous System Diseases Fibrosis Antibodies >24 publications with SDC1 and Fibrosis Neoplasms, Experimental Antibodies >23 publications with SDC1 and Neoplasms, Experimental Kidney Diseases Antibodies >20 publications with SDC1 and Kidney Diseases Lung Neoplasms Antibodies >19 publications with SDC1 and Lung Neoplasms Organs/Tissues associated with SDC1 recombinant protein Organ/Tissue Name Pubmed Publications Liver Antibodies >41 publications with SDC1 and Liver Kidney Antibodies >37 publications with SDC1 and Kidney Lung Antibodies >33 publications with SDC1 and Lung Connective Tissue Antibodies >21 publications with SDC1 and Connective Tissue Embryonic Tissue Antibodies >21 publications with SDC1 and Embryonic Tissue Brain Antibodies >17 publications with SDC1 and Brain Spleen Antibodies >15 publications with SDC1 and Spleen Eye Antibodies >14 publications with SDC1 and Eye Heart Antibodies >14 publications with SDC1 and Heart Prostate Antibodies >12 publications with SDC1 and Prostate TOP © 2006-24 MyBioSource.com. 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