NP_001159375.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,995 Da
NCBI Official Full Name
syntaxin-1A isoform 2
NCBI Official Synonym Full Names
syntaxin 1A (brain)
NCBI Protein Information
syntaxin-1A; neuron-specific antigen HPC-1
UniProt Protein Name
Syntaxin-1A
UniProt Synonym Protein Names
Neuron-specific antigen HPC-1
UniProt Synonym Gene Names
UniProt Entry Name
STX1A_HUMAN
NCBI Summary for STX1A
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for STX1A
STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.
Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; integral to membrane; extracellular region; plasma membrane; endomembrane system; actomyosin; cell junction; cytosol; secretory granule
Molecular Function: protein binding, bridging; protein domain specific binding; SNAP receptor activity; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; protein binding; SNARE binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding
Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic transmission; vesicle docking; cellular protein metabolic process; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; secretion by cell; synaptic vesicle docking during exocytosis; positive regulation of exocytosis
Research Articles on STX1A
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Products associated with STX1A recombinant protein
Pathways associated with STX1A recombinant protein
Diseases associated with STX1A recombinant protein
Organs/Tissues associated with STX1A recombinant protein
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