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STX1A recombinant protein :: Syntaxin 1A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203020
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Syntaxin 1A (STX1A), Recombinant Protein

★Popular Item★
 Also Known As   

Syntaxin 1A, 1-226aa, Human, E Coli

 Product Synonym Names    STX1A; STX1; Syntaxin 1A; Neuron-specific antigen HPC-1; Syntaxin-1A; HPC 1; Neuron specific antigen HPC1; STX1; Syntaxin 1A brain.
 Product Gene Name   

STX1A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQ
 OMIM    L37792 mRNA
 3D Structure    ModBase 3D Structure for Q16623
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    In 20mM Tris (pH 7.5), 1mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of STX1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for STX1A recombinant protein

   Syntaxin is membrane integrated Q-SNARE protein participating in exocytosis. Syntaxin is composed of an N-terminal regulatory domain (Habc), a SNARE domain (known as H3), and a single C-terminal transmembrane domain. The SNARE (H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex. Recombinant syntaxin 1A protein (1-226aa) contains N-terminal domain (Habc) and t_SNARE domain (H3 domain) and this protein was overexpressed in E Coli and purified by using the conventional column chromatography techniques.
 Product Categories/Family for STX1A recombinant protein    Neuroscience
 Applications Tested/Suitable for STX1A recombinant protein   

SDS-PAGE

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 SDS-Page of STX1A recombinant protein    STX1A recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for STX1A. It may not necessarily be applicable to this product.
 NCBI GI #    4759182
 NCBI GeneID    6804
 NCBI Accession #    NP_004594 [Other Products]
 NCBI GenBank Nucleotide #    NM_004603.3 [Other Products]
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 UniProt Primary Accession #    Q16623 [Other Products]
 UniProt Secondary Accession #    O15447; O15448; Q12936; Q75MD9; Q7Z5K3; Q9BPZ6 [Other Products]
 UniProt Related Accession #    Q16623 [Other Products]
 Molecular Weight    26.1 kDa (226 aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    syntaxin-1A isoform 1
 NCBI Official Synonym Full Names    syntaxin 1A
 NCBI Official Symbol    STX1A [Similar Products]
 NCBI Official Synonym Symbols   
STX1; HPC-1; P35-1; SYN1A
[Similar Products]
 NCBI Protein Information    syntaxin-1A
 UniProt Protein Name    Syntaxin-1A
 UniProt Synonym Protein Names   
Neuron-specific antigen HPC-1
 Protein Family    Syntaxin
 UniProt Gene Name    STX1A [Similar Products]
 UniProt Synonym Gene Names    STX1 [Similar Products]
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 NCBI Summary for STX1A    This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for STX1A    Plays a role in hormone and neurotransmitter exocytosis (). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.
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Product References and Citations for STX1A recombinant protein

   Han X., et al. (2004) Science. 304:289-292; Woodbury DJ. et al. (2000) Cell Biology International. 24 (11):809-818.;
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 Research Articles on STX1A    1. Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STX1A recombinant proteinPathways associated with STX1A recombinant protein
 Reference Product  PubMed Publications
 SNAP25 recombinant protein  >110 publications with STX1A and SNAP25
 VAMP2 recombinant protein  >40 publications with STX1A and VAMP2
 STXBP1 recombinant protein  >27 publications with STX1A and STXBP1
 SYT1 recombinant protein  >20 publications with STX1A and SYT1
 RAB3A recombinant protein  >8 publications with STX1A and RAB3A
 CPLX1 recombinant protein  >2 publications with STX1A and CPLX1
 TXLNA recombinant protein  >1 publications with STX1A and TXLNA
 UNC13B recombinant protein  >1 publications with STX1A and UNC13B
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Diseases associated with STX1A recombinant proteinOrgans/Tissues associated with STX1A recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >36 publications with STX1A and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >16 publications with STX1A and Neurobehavioral Manifestations
 Fibrosis Antibodies  >14 publications with STX1A and Fibrosis
 Cardiovascular Diseases Antibodies  >14 publications with STX1A and Cardiovascular Diseases
 Heart Diseases Antibodies  >13 publications with STX1A and Heart Diseases
 Diabetes Mellitus Antibodies  >9 publications with STX1A and Diabetes Mellitus
 Disease Models, Animal Antibodies  >9 publications with STX1A and Disease Models, Animal
 Memory Disorders Antibodies  >3 publications with STX1A and Memory Disorders
 Nerve Degeneration Antibodies  >3 publications with STX1A and Nerve Degeneration
 Learning Disorders Antibodies  >3 publications with STX1A and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >297 publications with STX1A and Nerve
 Brain Antibodies  >164 publications with STX1A and Brain
 Pancreas Antibodies  >39 publications with STX1A and Pancreas
 Embryonic Tissue Antibodies  >28 publications with STX1A and Embryonic Tissue
 Kidney Antibodies  >24 publications with STX1A and Kidney
 Muscle Antibodies  >20 publications with STX1A and Muscle
 Eye Antibodies  >15 publications with STX1A and Eye
 Lung Antibodies  >9 publications with STX1A and Lung
 Ganglia Antibodies  >6 publications with STX1A and Ganglia
 Mouth Antibodies  >6 publications with STX1A and Mouth
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