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SNCa recombinant protein :: Synuclein Alpha (SNCa) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018674 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $285 +1 FREE 8GB USB
0.1 mg  /  $445 +1 FREE 8GB USB
0.2 mg  /  $545 +1 FREE 8GB USB
0.5 mg  /  $1,055 +1 FREE 8GB USB
1 mg  /  $1,575 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synuclein Alpha (SNCa), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Synuclein Alpha (SNCa)

 Product Gene Name   

SNCa recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Synuclein Alpha (SNCa) (MBS2015217)
Antigen: Synuclein Alpha (SNCa) (MBS2018674)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
 Chromosome Location    Chromosome: 4; NC_005103.3 (155592411..155690724, complement). Location: 4q24
 3D Structure    ModBase 3D Structure for P37377
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Lys23~Ala140 (Accession # P37377) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of SNCa recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SNCa recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for SNCa recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of SNCa recombinant protein    SNCa recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SNCa. It may not necessarily be applicable to this product.
 NCBI GI #    9507125
 NCBI GeneID    29219
 NCBI Accession #    NP_062042.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019169.2 [Other Products]
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 UniProt Primary Accession #    P37377 [Other Products]
 UniProt Secondary Accession #    P37378; Q53YM9 [Other Products]
 UniProt Related Accession #    P37377 [Other Products]
 Molecular Weight    13.7kDa
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 NCBI Official Full Name    alpha-synuclein
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    Snca [Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 Protein Family    Alpha-synuclein
 UniProt Gene Name    Snca [Similar Products]
 UniProt Entry Name    SYUA_RAT
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 NCBI Summary for SNCa    may play a role in regulation of synaptic vesicle biogenesis and organization; may be involved in neurotransmission [RGD, Feb 2006]
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 UniProt Comments for SNCa    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; terminal button; inclusion body; cytosol; synaptic vesicle; platelet alpha granule membrane; perinuclear region of cytoplasm; cytoplasm; synapse; cytoplasmic vesicle membrane; rough endoplasmic reticulum; intracellular membrane-bound organelle; cell; fibril; cell cortex; actin cytoskeleton; growth cone; cytoskeleton; axon; plasma membrane; ribosome; nerve terminal; nucleus

Molecular Function: identical protein binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; magnesium ion binding; calcium ion binding; Hsp70 protein binding; oxidoreductase activity; enzyme binding; phospholipase binding; phospholipid binding; fatty acid binding; alpha-tubulin binding; protein domain specific binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; protein N-terminus binding; phosphoprotein binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; tau protein binding

Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; calcium ion homeostasis; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; regulation of neuronal synaptic plasticity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of dopamine uptake; negative regulation of histone acetylation; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of macrophage activation; negative regulation of microtubule polymerization; regulation of glutamate secretion; synaptic vesicle transport; response to cocaine; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
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 Research Articles on SNCa    1. Our data show that changes in the S129 residue of alpha-synuclein influence the rate of pathology and neurodegeneration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNCa recombinant proteinPathways associated with SNCa recombinant protein
 Reference Product  PubMed Publications
 Park2 recombinant protein  >872 publications with SNCa and Park2
 Lrrk2 recombinant protein  >123 publications with SNCa and Lrrk2
 Mapt recombinant protein  >70 publications with SNCa and Mapt
 Park7 recombinant protein  >51 publications with SNCa and Park7
 Sncaip recombinant protein  >31 publications with SNCa and Sncaip
 Slc6a3 recombinant protein  >12 publications with SNCa and Slc6a3
 Stub1 recombinant protein  >1 publications with SNCa and Stub1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
Diseases associated with SNCa recombinant proteinOrgans/Tissues associated with SNCa recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1087 publications with SNCa and Nervous System Diseases
 Brain Diseases Antibodies  >1065 publications with SNCa and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1053 publications with SNCa and Neurodegenerative Diseases
 Movement Disorders Antibodies  >931 publications with SNCa and Movement Disorders
 Parkinsonian Disorders Antibodies  >864 publications with SNCa and Parkinsonian Disorders
 Parkinson Disease Antibodies  >810 publications with SNCa and Parkinson Disease
 Lewy Body Disease Antibodies  >274 publications with SNCa and Lewy Body Disease
 Nerve Degeneration Antibodies  >163 publications with SNCa and Nerve Degeneration
 Disease Models, Animal Antibodies  >133 publications with SNCa and Disease Models, Animal
 Neoplasms Antibodies  >58 publications with SNCa and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >744 publications with SNCa and Brain
 Eye Antibodies  >10 publications with SNCa and Eye
 Heart Antibodies  >9 publications with SNCa and Heart
 Liver Antibodies  >7 publications with SNCa and Liver
 Dorsal Root Ganglion Antibodies  >5 publications with SNCa and Dorsal Root Ganglion
 Prostate Antibodies  >1 publications with SNCa and Prostate
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