NP_035665.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-box transcription factor TBX3 isoform 1
NCBI Official Synonym Full Names
T-box 3
NCBI Official Synonym Symbols
NCBI Protein Information
T-box transcription factor TBX3; T-box protein 3
UniProt Protein Name
T-box transcription factor TBX3
UniProt Synonym Gene Names
UniProt Entry Name
TBX3_MOUSE
UniProt Comments for TBX3
TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Cellular Component: transcription factor complex; nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: heart morphogenesis; transcription from RNA polymerase II promoter; embryonic forelimb morphogenesis; limbic system development; multicellular organismal development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; palate development; female genitalia development; embryonic hindlimb morphogenesis; cardiac muscle cell differentiation; forelimb morphogenesis; regulation of transcription, DNA-dependent; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; cell aging; positive regulation of cell cycle; limb morphogenesis; regulation of cell proliferation; organ morphogenesis; mesoderm morphogenesis; embryonic heart tube development; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; negative regulation of apoptosis
Research Articles on TBX3
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Pathways associated with TBX3 recombinant protein
Diseases associated with TBX3 recombinant protein
Organs/Tissues associated with TBX3 recombinant protein
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