NP_001073977.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-box transcription factor TBX18
NCBI Official Synonym Full Names
T-box 18
NCBI Official Synonym Symbols
NCBI Protein Information
T-box transcription factor TBX18
UniProt Protein Name
T-box transcription factor TBX18
UniProt Synonym Gene Names
NCBI Summary for TBX18
This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
UniProt Comments for TBX18
TBX18: Probable transcriptional regulator involved in developmental processes.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6q14.3
Cellular Component: nucleus
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Disease: Congenital Anomalies Of Kidney And Urinary Tract 2; Huntington Disease
Research Articles on TBX18
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Diseases associated with TBX18 recombinant protein
Organs/Tissues associated with TBX18 recombinant protein
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