NP_005985.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,066 Da
NCBI Official Full Name
T-box transcription factor TBX2
NCBI Official Synonym Full Names
T-box 2
NCBI Protein Information
T-box transcription factor TBX2
UniProt Protein Name
T-box transcription factor TBX2
UniProt Synonym Gene Names
NCBI Summary for TBX2
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX2
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.
Research Articles on TBX2
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Products associated with TBX2 recombinant protein
Pathways associated with TBX2 recombinant protein
Diseases associated with TBX2 recombinant protein
Organs/Tissues associated with TBX2 recombinant protein
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