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TES recombinant protein

Scan QR to view Datasheet Catalog #    MBS203683
SDS-Page
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TES, Recombinant Protein

 Also Known As   

TES, 1-421aa, Human, His tag, E Coli

 Product Synonym Names    Testin; TESS; TESS-2; Testin
 Product Gene Name   

TES recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVECKKRM S
 OMIM    AF260225 Genomic DNA
 3D Structure    ModBase 3D Structure for Q9UGI8
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of TES recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TES recombinant protein

   TES is a tumor suppressor protein and may play role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. This protein localizes to cell-cell contacts and actin stress fibres, and interacts with a variety of cytoskeletal proteins including Zyxin, Mena, VASP, Talin and Actin. The ability of TES to associate with alpha-actinin, paxillin and Zyxin is dependent on the conformational state of the molecule. Recombinant human TES protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for TES recombinant protein    Cancer
 Applications Tested/Suitable for TES recombinant protein   

SDS-PAGE

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 SDS-Page of TES recombinant protein    TES recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for TES. It may not necessarily be applicable to this product.
 NCBI GI #    7661666
 NCBI GeneID    26136
 NCBI Accession #    NP_056456 [Other Products]
 NCBI GenBank Nucleotide #    NM_015641.3 [Other Products]
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 UniProt Primary Accession #    Q9UGI8 [Other Products]
 UniProt Secondary Accession #    Q9GZQ1; Q9HAJ9; A4D0U6 [Other Products]
 UniProt Related Accession #    Q9UGI8 [Other Products]
 Molecular Weight    50.1 kDa (441aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    testin isoform 1
 NCBI Official Synonym Full Names    testin LIM domain protein
 NCBI Official Symbol    TES [Similar Products]
 NCBI Official Synonym Symbols   
TESS; TESS-2
[Similar Products]
 NCBI Protein Information    testin
 UniProt Protein Name    Testin
 UniProt Synonym Protein Names   
TESS
 Protein Family    Tesmin
 UniProt Gene Name    TES [Similar Products]
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 NCBI Summary for TES    Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]
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 UniProt Comments for TES    Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
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Product References and Citations for TES recombinant protein

   Qiu H., et al. (2010) Cancer Sci. 101 (5):1255-60.; Sato T., et al. (2003) J Biol Chem. 278 (48):47534-44.;
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 Research Articles on TES    1. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with TES recombinant proteinOrgans/Tissues associated with TES recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >263 publications with TES and Nervous System Diseases
 Heart Diseases Antibodies  >99 publications with TES and Heart Diseases
 Liver Diseases Antibodies  >48 publications with TES and Liver Diseases
 Disease Models, Animal Antibodies  >43 publications with TES and Disease Models, Animal
 Hemorrhage Antibodies  >38 publications with TES and Hemorrhage
 Inflammation Antibodies  >32 publications with TES and Inflammation
 Breast Neoplasms Antibodies  >30 publications with TES and Breast Neoplasms
 Hypertension Antibodies  >29 publications with TES and Hypertension
 Necrosis Antibodies  >29 publications with TES and Necrosis
 Liver Neoplasms Antibodies  >28 publications with TES and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >537 publications with TES and Blood
 Brain Antibodies  >451 publications with TES and Brain
 Muscle Antibodies  >276 publications with TES and Muscle
 Skin Antibodies  >251 publications with TES and Skin
 Heart Antibodies  >200 publications with TES and Heart
 Vascular Antibodies  >196 publications with TES and Vascular
 Nerve Antibodies  >176 publications with TES and Nerve
 Bone Antibodies  >148 publications with TES and Bone
 Liver Antibodies  >104 publications with TES and Liver
 Eye Antibodies  >92 publications with TES and Eye
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