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TGF ALPHA recombinant protein

Scan QR to view Datasheet Catalog #    MBS232239 TGF ALPHA recombinant protein
Unit / Price
0.1 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF ALPHA, Recombinant Protein

★Popular Item★
 Also Known As   

RECOMBINANT HUMAN TGF ALPHA

 Product Gene Name   

TGF ALPHA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190170
 3D Structure    ModBase 3D Structure for P01135
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 Species Reactivity    Mouse
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 Purity/Purification    >98% by SDS PAGE and HPLC
 Form/Format    Recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 1.0 mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage the addition of 0.1% bovine serum albumin (BSA) is recommended.
Preparation
 Activity    >1.4 x 106 Units/mg
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of TGF ALPHA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TGF ALPHA recombinant protein

   Recombinant human TGFalpha is a 5.5kDa peptide corresponding to full-length mature human transforming growth factor alpha. TGFalpha is an EGF-related growth factor that stimulates the proliferation of epidermal and epithelial cells.
 Applications Tested/Suitable for TGF ALPHA recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for TGF ALPHA recombinant protein    ELISA: Recombinant human TGFalpha may be used as a standard for ELISA applications with either a purifed human TGFalpha antibody or a biotinylated human TGFalpha antibody.
Western Blot: Recombinant human TGFalpha may be used as the positive control for Western Blotting applications with either a purified human TGFalpha antibody or a biotinylated human TGFalpha antibody.
ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well
Functional Assays: Minimum Dilution: 0.5; Maximum Dilution: 25ng/ml
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for TGF ALPHA. It may not necessarily be applicable to this product.
 NCBI GI #    153791414
 NCBI GeneID    7039
 NCBI Accession #    NP_001093161.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001099691.2 [Other Products]
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 UniProt Primary Accession #    P01135 [Other Products]
 UniProt Secondary Accession #    Q15577; Q53SK7; Q9BS56; Q9UEI3; Q9UKM1; Q9UKM2; Q9UKM3; A8K286 [Other Products]
 UniProt Related Accession #    P01135 [Other Products]
 Molecular Weight    Protein Molecular Weight: 5.5kD (50 Amino Acid Sequence)
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 NCBI Official Full Name    protransforming growth factor alpha isoform 2 preproprotein
 NCBI Official Synonym Full Names    transforming growth factor, alpha
 NCBI Official Symbol    TGFA [Similar Products]
 NCBI Official Synonym Symbols   
TFGA
[Similar Products]
 NCBI Protein Information    protransforming growth factor alpha; TGF-alpha
 UniProt Protein Name    Protransforming growth factor alpha
 UniProt Synonym Protein Names   
EGF-like TGF; ETGF; TGF type 1
 UniProt Gene Name    TGFA [Similar Products]
 UniProt Synonym Gene Names    TGF-alpha; ETGF [Similar Products]
 UniProt Entry Name    TGFA_HUMAN
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 NCBI Summary for TGF ALPHA    This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for TGF ALPHA    TGFalpha: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: extracellular space; cell surface; basolateral plasma membrane; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; cytoplasmic vesicle; nucleus

Molecular Function: protein binding; growth factor activity; glycoprotein binding; epidermal growth factor receptor binding

Biological Process: response to drug; epidermal growth factor receptor signaling pathway; cell proliferation; wound healing; positive regulation of epidermal growth factor receptor activity; positive regulation of mitosis; activation of MAPK activity; angiogenesis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
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 Research Articles on TGF ALPHA    1. TGFA Taq I polymorphism may be associated with the risk of cleft lip and/or palate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGF ALPHA recombinant proteinPathways associated with TGF ALPHA recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >43 publications with TGF ALPHA and EGFR
 ERBB2 recombinant protein  >8 publications with TGF ALPHA and ERBB2
 TNF recombinant protein  >7 publications with TGF ALPHA and TNF
 IL6 recombinant protein  >6 publications with TGF ALPHA and IL6
 ERBB4 recombinant protein  >4 publications with TGF ALPHA and ERBB4
 TP53 recombinant protein  >3 publications with TGF ALPHA and TP53
 ERBB3 recombinant protein  >3 publications with TGF ALPHA and ERBB3
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
Diseases associated with TGF ALPHA recombinant proteinOrgans/Tissues associated with TGF ALPHA recombinant protein
 Disease Name  Pubmed Publications
 Genetic Predisposition to Disease Antibodies  >21 publications with TGF ALPHA and Genetic Predisposition to Disease
 Fatty Liver Antibodies  >16 publications with TGF ALPHA and Fatty Liver
 Liver Diseases Antibodies  >10 publications with TGF ALPHA and Liver Diseases
 Liver Neoplasms Antibodies  >10 publications with TGF ALPHA and Liver Neoplasms
 Head and Neck Neoplasms Antibodies  >9 publications with TGF ALPHA and Head and Neck Neoplasms
 Breast Neoplasms Antibodies  >9 publications with TGF ALPHA and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >7 publications with TGF ALPHA and Prostatic Neoplasms
 Inflammation Antibodies  >7 publications with TGF ALPHA and Inflammation
 Nervous System Diseases Antibodies  >7 publications with TGF ALPHA and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >7 publications with TGF ALPHA and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with TGF ALPHA and Blood
 Muscle Antibodies  >12 publications with TGF ALPHA and Muscle
 Intestine Antibodies  >11 publications with TGF ALPHA and Intestine
 Mouth Antibodies  >8 publications with TGF ALPHA and Mouth
 Lung Antibodies  >8 publications with TGF ALPHA and Lung
 Stomach Antibodies  >7 publications with TGF ALPHA and Stomach
 Kidney Antibodies  >7 publications with TGF ALPHA and Kidney
 Skin Antibodies  >6 publications with TGF ALPHA and Skin
 Brain Antibodies  >5 publications with TGF ALPHA and Brain
 Nerve Antibodies  >4 publications with TGF ALPHA and Nerve
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