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TIFA recombinant protein

Scan QR to view Datasheet Catalog #    MBS204665
SDS-Page
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIFA, Recombinant Protein

★Popular Item★
 Also Known As   

TIFA, 1-184aa, Human, His tag, E Coli

 Product Synonym Names    TRAF-interacting protein with FHA domain-containing protein A; T2BP; T6BP; TIFAA
 Product Gene Name   

TIFA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMTSFED ADTEETVTCL QMTVYHPGQL QCGIFQSISF NREKLPSSEV VKFGRNSNIC HYTFQDKQVS RVQFSLQLFK KFNSSVLSFE IKNMSKKTNL IVDSRELGYL NKMDLPYRCM VRFGEYQFLM EKEDGESLEF FETQFILSPR SLLQENNWPP HRPIPEYGTY SLCSSQSSSP TEMDENES
 OMIM    AB062110 mRNA
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of TIFA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TIFA recombinant protein

   TIFA, also known as TRAF-interacting protein with FHA domain-containing protein A, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. This protein induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. Recombinant human TIFA protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for TIFA recombinant protein    Signal Transduction
 Applications Tested/Suitable for TIFA recombinant protein   

SDS-PAGE

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 SDS-Page of TIFA recombinant protein    TIFA recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for TIFA. It may not necessarily be applicable to this product.
 NCBI GI #    33563370
 NCBI GeneID    92610
 NCBI Accession #    NP_443096 [Other Products]
 NCBI GenBank Nucleotide #    NM_052864.2 [Other Products]
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 UniProt Related Accession #    Q96CG3 [Other Products]
 Molecular Weight    24.0 kDa (208aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    TRAF-interacting protein with FHA domain-containing protein A
 NCBI Official Synonym Full Names    TRAF interacting protein with forkhead associated domain
 NCBI Official Symbol    TIFA [Similar Products]
 NCBI Official Synonym Symbols   
T2BP; T6BP; TIFAA
[Similar Products]
 NCBI Protein Information    TRAF-interacting protein with FHA domain-containing protein A
 UniProt Protein Name    TRAF-interacting protein with FHA domain-containing protein A
 UniProt Synonym Protein Names   
Putative MAPK-activating protein PM14; Putative NF-kappa-B-activating protein 20; TRAF2-binding protein
 Protein Family    TRAF-interacting protein with FHA domain-containing protein
 UniProt Gene Name    TIFA [Similar Products]
 UniProt Synonym Gene Names    T2BP [Similar Products]
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 UniProt Comments for TIFA    Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
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Product References and Citations for TIFA recombinant protein

   Takatsuna H., et al. (2003) J. Biol. Chem. 278:12144-12150; Ea C.-K., et al. (2004) Proc. Natl. Acad. Sci. u.S.A. 101:15318-15323
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 Research Articles on TIFA    1. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TIFA recombinant proteinPathways associated with TIFA recombinant protein
 Reference Product  PubMed Publications
 TRAF6 recombinant protein  >12 publications with TIFA and TRAF6
 TIFAB recombinant protein  >3 publications with TIFA and TIFAB
 TRAF2 recombinant protein  >2 publications with TIFA and TRAF2
 ZCCHC11 recombinant protein  >1 publications with TIFA and ZCCHC11
 Products by Pathway  Pathway Diagram
 Interleukin-1 Induced Activation Of NF-kappa-B Pathway antibodies  Interleukin-1 Induced Activation Of NF-kappa-B Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 Simplified Depiction Of MYD88 Distinct Input-Output Pathway antibodies  Simplified Depiction Of MYD88 Distinct Input-Output Pathway Diagram
Diseases associated with TIFA recombinant proteinOrgans/Tissues associated with TIFA recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >10 publications with TIFA and Necrosis
 Inflammation Antibodies  >6 publications with TIFA and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with TIFA and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with TIFA and Cardiovascular Diseases
 Death Antibodies  >1 publications with TIFA and Death
 Hemorrhage Antibodies  >1 publications with TIFA and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with TIFA and Bone
 Blood Antibodies  >4 publications with TIFA and Blood
 Liver Antibodies  >3 publications with TIFA and Liver
 Bone Marrow Antibodies  >2 publications with TIFA and Bone Marrow
 Spleen Antibodies  >1 publications with TIFA and Spleen
 Eye Antibodies  >1 publications with TIFA and Eye
 Lymph Antibodies  >1 publications with TIFA and Lymph
 Kidney Antibodies  >1 publications with TIFA and Kidney
 Skin Antibodies  >1 publications with TIFA and Skin
 Thymus Antibodies  >1 publications with TIFA and Thymus
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