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TIFF3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539586 TIFF3 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TIFF3, Recombinant Protein

 Also Known As   

TIFF3 protein

 Product Synonym Names    TIFF-3 protein; TIFF 3; Intestinal trefoil factor protein; TIFF-3; Trefoil Factor 3 protein; ITF protein; TFI protein; TIFF 3 protein; TIFF3
 Product Gene Name   

TIFF3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of TIFF3 protein correspond ing to amino acids EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF.
 OMIM    600633
 3D Structure    ModBase 3D Structure for Q07654
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
 Bioactivity    Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 ug/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of TIFF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TIFF3 recombinant protein

   Purified recombinant Human TIFF3 protein
 Product Categories/Family for TIFF3 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for TIFF3 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for TIFF3. It may not necessarily be applicable to this product.
 NCBI GI #    281485608
 NCBI GeneID    7033
 NCBI Accession #    NP_003217.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003226.3 [Other Products]
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 UniProt Primary Accession #    Q07654 [Other Products]
 UniProt Secondary Accession #    Q96NX0; Q9UDA5; E9PBB5 [Other Products]
 UniProt Related Accession #    Q07654 [Other Products]
 Molecular Weight    13.2 kDa
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 NCBI Official Full Name    trefoil factor 3
 NCBI Official Synonym Full Names    trefoil factor 3 (intestinal)
 NCBI Official Symbol    TFF3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    trefoil factor 3
 UniProt Protein Name    Trefoil factor 3
 UniProt Synonym Protein Names   
Intestinal trefoil factor; hITF; Polypeptide P1.B; hP1.B
 UniProt Gene Name    TFF3 [Similar Products]
 UniProt Synonym Gene Names    ITF; TFI; hITF; hP1.B [Similar Products]
 UniProt Entry Name    TFF3_HUMAN
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 NCBI Summary for TIFF3    Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIFF3    TFF3: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region; secretory granule

Biological Process: response to peptide hormone stimulus; digestion; defense response
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 Research Articles on TIFF3    1. ERG and TFF3 expression characterize 2 distinct subsets of prostate cancer, with a more aggressive subgroup of TFF3-expressing tumors that express SPINK1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TIFF3 recombinant proteinPathways associated with TIFF3 recombinant protein
 Reference Product  PubMed Publications
 TFF1 recombinant protein  >211 publications with TIFF3 and TFF1
 TFF2 recombinant protein  >168 publications with TIFF3 and TFF2
 EGFR recombinant protein  >13 publications with TIFF3 and EGFR
 CTNNB1 recombinant protein  >10 publications with TIFF3 and CTNNB1
 ERBB2 recombinant protein  >7 publications with TIFF3 and ERBB2
 HIF1A recombinant protein  >4 publications with TIFF3 and HIF1A
 STAT6 recombinant protein  >4 publications with TIFF3 and STAT6
 RELA recombinant protein  >1 publications with TIFF3 and RELA
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
Diseases associated with TIFF3 recombinant proteinOrgans/Tissues associated with TIFF3 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >115 publications with TIFF3 and Carcinoma
 Inflammation Antibodies  >67 publications with TIFF3 and Inflammation
 Adenocarcinoma Antibodies  >62 publications with TIFF3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >40 publications with TIFF3 and Breast Neoplasms
 Hyperplasia Antibodies  >28 publications with TIFF3 and Hyperplasia
 Necrosis Antibodies  >26 publications with TIFF3 and Necrosis
 Neoplasm Metastasis Antibodies  >21 publications with TIFF3 and Neoplasm Metastasis
 Liver Diseases Antibodies  >17 publications with TIFF3 and Liver Diseases
 Prostatic Neoplasms Antibodies  >14 publications with TIFF3 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >14 publications with TIFF3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >335 publications with TIFF3 and Muscle
 Intestine Antibodies  >221 publications with TIFF3 and Intestine
 Stomach Antibodies  >169 publications with TIFF3 and Stomach
 Liver Antibodies  >46 publications with TIFF3 and Liver
 Brain Antibodies  >30 publications with TIFF3 and Brain
 Thyroid Antibodies  >26 publications with TIFF3 and Thyroid
 Kidney Antibodies  >26 publications with TIFF3 and Kidney
 Pancreas Antibodies  >23 publications with TIFF3 and Pancreas
 Lung Antibodies  >22 publications with TIFF3 and Lung
 Eye Antibodies  >16 publications with TIFF3 and Eye
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