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| Product Name
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TIFF3, Recombinant Protein
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| Also Known As
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TIFF3 protein
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| Product Synonym Names
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TIFF-3 protein; TIFF 3; Intestinal trefoil factor protein; TIFF-3; Trefoil Factor 3 protein; ITF protein; TFI protein; TIFF 3 protein; TIFF3
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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Region of TIFF3 protein correspond ing to amino acids EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF.
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| OMIM
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600633
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| 3D Structure
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ModBase 3D Structure for Q07654
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| Host
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Human
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| Purity/Purification
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> 98% pure
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| Form/Format
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Supplied as a lyophilized powder.
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| Protein Type
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Recombinant
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| Biological Significance
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The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
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| Bioactivity
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Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 ug/ml.
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| Endotoxin Levels
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Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
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| Expression System
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E Coli
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| Preparation and Storage
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Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
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| Other Notes
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Small volumes of TIFF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Purified recombinant Human TIFF3 protein
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| Product Categories/Family for TIFF3 recombinant protein
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Cytokines & Growth Factors
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| Applications Tested/Suitable for TIFF3 recombinant protein
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User optimized
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TOP
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| NCBI/Uniprot data below describe general gene information for TIFF3. It may not necessarily be applicable to this product. |
| NCBI GI #
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281485608
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| NCBI GeneID
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7033
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| NCBI Accession #
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NP_003217.3
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_003226.3
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[Other Products]
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| UniProt Primary Accession #
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Q07654
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[Other Products]
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| UniProt Secondary Accession #
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Q96NX0; Q9UDA5; E9PBB5
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[Other Products]
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| UniProt Related Accession #
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Q07654
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[Other Products]
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| Molecular Weight
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13.2 kDa
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TOP
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| NCBI Official Full Name
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trefoil factor 3
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| NCBI Official Synonym Full Names
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trefoil factor 3 (intestinal)
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| NCBI Official Symbol
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TFF3
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[Similar Products]
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| NCBI Official Synonym Symbols
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ITF; P1B; TFI
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[Similar Products]
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| NCBI Protein Information
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trefoil factor 3
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| UniProt Protein Name
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Trefoil factor 3
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| UniProt Synonym Protein Names
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Intestinal trefoil factor; hITF; Polypeptide P1.B; hP1.B
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| UniProt Gene Name
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TFF3
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[Similar Products]
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| UniProt Synonym Gene Names
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ITF; TFI; hITF; hP1.B
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[Similar Products]
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| UniProt Entry Name
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TFF3_HUMAN
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| NCBI Summary for TIFF3
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Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
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| UniProt Comments for TIFF3
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TFF3: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: proteinaceous extracellular matrix; extracellular region; secretory granule
Biological Process: response to peptide hormone stimulus; digestion; defense response
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TOP
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| Research Articles on TIFF3
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1. ERG and TFF3 expression characterize 2 distinct subsets of prostate cancer, with a more aggressive subgroup of TFF3-expressing tumors that express SPINK1.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with TIFF3 recombinant protein | Pathways associated with TIFF3 recombinant protein |
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| Diseases associated with TIFF3 recombinant protein | Organs/Tissues associated with TIFF3 recombinant protein |
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TOP
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Recombinant Protein 
