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TNFSF12 recombinant protein :: TNF Ligand Superfamily Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143906 TNFSF12 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNF Ligand Superfamily (TNFSF12), Recombinant Protein

 Also Known As   

Recombinant Human TNF Ligand Superfamily Member 12

 Product Synonym Names    TNFSF12 Human; TNF Ligand Superfamily Member 12 Human Recombinant; TWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; Apo3-Ligand; APO3L; TNFRSF12A; Tumor necrosis factor ligand superfamily member 12; MGC20669; MGC129581
 Product Gene Name   

TNFSF12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MHHHHHHRSA PKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
 OMIM    602695
 3D Structure    ModBase 3D Structure for O43508
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 Host    HEK293
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Filtered and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl pH-7.5.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    Add pyrogen free water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized TWEAK Human recombinant at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of TNFSF12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNFSF12 recombinant protein

   Description: The TWEAK Human Recombinant is manufactured with N-terminal fusion of 13 amino acid FLAG Tag. The TNFSF12 Flag -Tagged Fusion Protein has a Mw of 18.7kDa containing a total of 169 amino acid residues.

Introduction: TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 exerts an apoptotic activity in HT-29 human adenocarcinoma cells whilst cultured in the presence of IFN-?. TNFSF12 promotes proliferation and migration of endothelial cells.
 Product Categories/Family for TNFSF12 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Tumor Necrosis Factor
NCBI/Uniprot data below describe general gene information for TNFSF12. It may not necessarily be applicable to this product.
 NCBI GI #    4507597
 NCBI GeneID    8742
 NCBI Accession #    NP_003800.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003809.2 [Other Products]
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 UniProt Primary Accession #    O43508 [Other Products]
 UniProt Secondary Accession #    Q8IZK7; Q8WUZ7 [Other Products]
 UniProt Related Accession #    O43508 [Other Products]
 Molecular Weight    36,589 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 12 proprotein
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 12
 NCBI Official Symbol    TNFSF12 [Similar Products]
 NCBI Official Synonym Symbols   
APO3L; DR3LG; TWEAK
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 12; APO3 ligand; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 12
 UniProt Synonym Protein Names   
APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF12 [Similar Products]
 UniProt Synonym Gene Names    APO3L; DR3LG; TWEAK [Similar Products]
 UniProt Entry Name    TNF12_HUMAN
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 NCBI Summary for TNFSF12    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
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 UniProt Comments for TNFSF12    TNFSF12: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to plasma membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: positive regulation of angiogenesis; apoptosis; positive regulation of protein catabolic process; endothelial cell migration; immune response; positive regulation of endothelial cell proliferation; angiogenesis; cell differentiation; signal transduction
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 Research Articles on TNFSF12    1. The TWEAK/Fn14 system may promote inflammation and tissue injury during peritonitis and peritoneal dialysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFSF12 recombinant proteinPathways associated with TNFSF12 recombinant protein
 Reference Product  PubMed Publications
 TNFSF10 recombinant protein  >18 publications with TNFSF12 and TNFSF10
 TNFRSF17 recombinant protein  >5 publications with TNFSF12 and TNFRSF17
 TNFRSF12A recombinant protein  >5 publications with TNFSF12 and TNFRSF12A
 TNFRSF13B recombinant protein  >4 publications with TNFSF12 and TNFRSF13B
 TNFRSF25 recombinant protein  >4 publications with TNFSF12 and TNFRSF25
 TRAF5 recombinant protein  >2 publications with TNFSF12 and TRAF5
 CD68 recombinant protein  >2 publications with TNFSF12 and CD68
 TNFRSF13C recombinant protein  >2 publications with TNFSF12 and TNFRSF13C
 AGGF1 recombinant protein  >2 publications with TNFSF12 and AGGF1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram
Organs/Tissues associated with TNFSF12 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >122 publications with TNFSF12 and Blood
 Vascular Antibodies  >68 publications with TNFSF12 and Vascular
 Kidney Antibodies  >61 publications with TNFSF12 and Kidney
 Muscle Antibodies  >43 publications with TNFSF12 and Muscle
 Brain Antibodies  >31 publications with TNFSF12 and Brain
 Bone Antibodies  >18 publications with TNFSF12 and Bone
 Heart Antibodies  >17 publications with TNFSF12 and Heart
 Liver Antibodies  >12 publications with TNFSF12 and Liver
 Connective Tissue Antibodies  >11 publications with TNFSF12 and Connective Tissue
 Lung Antibodies  >10 publications with TNFSF12 and Lung
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